Hedgehog signaling in the zebrafish embryo role of kif7 and DZIP1 2
Hedgehog signaling in the zebrafish embryo role of kif7 and DZIP1 2
... kinesin-like protein of 1363 amino acids was assembled Like Drosophila Cos2 and other members of the kinesin heavy chain (KHC) superfamily of proteins, the N-terminal and C-terminal regions of ... about the mechanism of the pathway The aim of this study focuses on two proteins, Cos2 /Kif7 and Iguana /Dzip1 Drosophila Cos2 plays an important role in Hh signal...
Hedgehog signaling in the zebrafish embryo role of kif7 and DZIP1 1
... Phosphoinositide Pathway 1. 10 Aim of Thesis 6 7 9 10 11 12 13 14 16 16 19 19 19 21 21 26 26 28 28 30 31 32 ii Chapter Materials and Methods 2 .1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 2 .10 2 .11 2 .12 2 .13 ... Hedgehog 1. 3.4 Regulation of Smoothened Activity 1. 4 Activation of Hedgehog protein 1. 5 Comparing Hedgehog Orthologs 1. 5 .1 Patched 1. 5.2 Smoothened...
Molecular mechanisms involved in the specification of embryonic ectoderm in the zebrafish embryo
... (Dsh) The amino-terminal extracellular Wnt binding domain and the 18 19 carboxy-terminal PDZ-binding domain of the Fz protein are known to be essential for Fz function Deletion of the PDZ-binding ... In this thesis, we use the zebrafish as a model to study the molecular mechanisms behind the specification of embryonic ectoderm Specifically, we attempt to isol...
Báo cáo y học: "SPLUNC1 regulation in airway epithelial cells: role of toll-like receptor 2 signaling" ppsx
... TLR2 signaling to induce inflammatory cytokine responses [39,40] These additional strains of bacteria will be included in our future studies Second, the in vivo role of airway epithelial TLR2 ... surfactant proteins A and D, mainly produced by type II alveolar epithelial cells and Clara cells, are also abundant in airway lining fluid They play a pivotal role in host de...
Báo cáo y học: " Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo" pptx
... multiplicity testing by controlling the false discovery rate [27] The differences between the transcriptional profiles induced by the six toxicants were less prominent in the datasets from the 4-24 hpf ... numbers of embryos and can thus average the individual gene responses by using pooled cDNA prepared from many embryos In the cases where we confirmed the gene res...
Báo cáo y học: "Ethnic differences in the mother-son relationship of incarcerated and non-incarcerated male adolescents in the Netherlands" docx
... Ethnic differences in the mother-son relationship of incarcerated and non -incarcerated male adolescents in the Netherlands Child and Adolescent Psychiatry and Mental Health 2011 5:23 Submit your ... Dutch and Moroccan mothers of incarcerated and non -incarcerated adolescents in each of the classes, Chi-square tests were used In order to identif...
Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling...
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss of fosfomycin binding to the K22V and K22E mutant proteins However, two other positively charged amino ... enthalpies of binding and stoichiometries were determined from the binding isotherm by fitting a : binding model to the data using the software provided by the m...
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... 2002 Aromatic stacking in API (Eur J Biochem 269) 4153 Fig Stick models of the reactive site in bovine trypsin and API The catalytic triad residues of trypsin and API are Ser195–His57– Asp102 and ... because several serine proteases not have an aspartate as the catalytic apparatus M NaCl However, for chymotrypsin-type serine proteases, the replacement of this aspar...
The Role of Small and Large Businesses in Economic Development doc
... innovation Small firms are the great innovators in some industries, while large firms are the great innovators in others Moreover, small and large businesses interact in innovative activity The ... businesses There is no clear evidence that small businesses are more effective innovators Further, the innovations of both small businesses and large busi...
Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx
... helix of the third cluster of CHCs is part of the inter-domain segment and the other helix lines the boundary between the major domain and the N-terminus (Fig 1) Therefore, the formation of the ... rather than functional role Role of hydrophobic contacts in serine hydroxymethyltransferase In the present study, the importance of the third hydrop...
Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... proteins (ACPs) [14,15] The genes dptE and dptF are localized immediately upstream of the NRPSs of A21987C The resulting proteins DptE and DptF were predicted to be involved in the lipidation reaction ... the initiation module of daptomycin That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al [...
Báo cáo Y học: Role of conserved residues within helices IV and VIII of the oxaloacetate decarboxylase b subunit in the energy coupling mechanism of the Na+ pump ppt
... that the < /b> Na+ binding of < /b> the < /b> decarboxylase < /b> (Km % mM) was dramatically affected by the < /b> S382A mutation We also investigated the < /b> stability of < /b> OadB with the < /b> S382A mutation in the < /b> presence of < /b> trypsin ... involving by R389 through lowering the < /b> pK of < /b> the < /b> tyrosine hydroxyl group The < /b> proton is delivere...
The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... when they did not understand the meaning of the questions in this section Each session took 30 including instructions at the beginning, the listening comprehension task, and completion of the ... placement in the IEP was determined on the basis of an in- house placement test of listening, reading, and writing skills (reliability coefficients for the list...
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