Role of misfolded nuclear receptor co repressor (n cor) in

Role of misfolded nuclear receptor co repressor (n cor) induced transcriptional de regulation in the pathogenesis of acute monocytic leukemia (AML m5

... 1.2 The Nuclear Receptor Co- repressor (N- CoR), a component of the transcriptional repression machinery and its role in AML pathogenesis 1.2.1 The importance of the transcription machinery in the ... these factors become key initiators of AML pathogenesis 1.2.2 The Nuclear Receptor Co- Repressor (N- CoR) The nuclear receptor co- re...

Ngày tải lên : 09/09/2015, 18:55

227
312
0

Báo cáo y học: " Th2 cytokines and asthma Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists" pot

... circulating cytokine, coupled with the high specificity and high affinity of binding for the cytokine, makes the soluble receptor ideal as a cytokine antagonist Soluble recombinant human IL-4 receptor ... heterodimer of high-affinity IL-4Rα and either the common γ chain or the IL-13 receptor α chain Binding of IL-4 results in the tyrosine phosphorylation of...

Ngày tải lên : 12/08/2014, 18:20

5
365
0

Inhibition of misfolded n cor induced survival pathway in APL by artemisinin

... INHIBITION OF MISFOLDED N- COR INDUCED SURVIVAL PATHWAY IN APL BY ARTEMISININ YEO HUI LING ANGIE (B.Sc.(Hons.), NTU) A THESIS SUBMITTED FOR THE DEGREE OF MASTER OF SCIENCE DEPARTMENT OF MEDICINE ... protein (Hsp) 70 chaperone family It consists of an N- terminal ATPase and a C-terminal substrate binding domain Conformational changes in GRP78 regulate its bind...

Ngày tải lên : 12/10/2015, 17:35

96
159
0

202 Chiến lược phát triển tổng Công ty cổ phần Bảo Minh đến năm 2015

... Bảo Minh Phú Thọ 34 Bảo Minh Bình Thuận Bảo Minh Bắc Ninh 35 Bảo Minh Bình Phước Bảo Minh Quảng Bình 36 Bảo Minh Đồng Nai Bảo Minh Hải Dương 37 Bảo Minh Bình Dương Bảo Minh Hưng n 38 Bảo Minh ... Bảo Minh Huế 48 Bảo Minh Bến Tre 20 Bảo Minh Đà Nẵng 49 Bảo Minh Trà Vinh 21 Bảo Minh Quảng Nam 50 Bảo Minh Cần Thơ 22 Bảo Minh Quảng Ngãi 51 Bảo Minh Kiên Giang 2...

Ngày tải lên : 27/03/2013, 16:25

87
657
0

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... 5B) and immunoblot analyses (Fig 5A) using mAbs specific to human Ku- 70 and Ku- 80 revealed that the MREa-binding proteins described herein and the Ku proteins are immunologically related The Ku ... transcriptional regulatory activity and that a variety of nuclear transcription factors interact specifically with MREa [11,33,38,39] These findings suggest...

Ngày tải lên : 17/03/2014, 23:20

11
628
0

báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" pptx

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients an...

Ngày tải lên : 20/06/2014, 04:20

8
445
0

báo cáo hóa học:" Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of bone" potx

... VEGF activates the VEGF-Flt-1-FAK pathway The activation of this signaling pathway might be involved in the migration of these cells into the lesion at the site of bone destruction in GCTs We recently ... order to determine the possible role of the VEGF-Flt-1-FAK pathway in the pathogenesis of bone destruction in GCTs Methods Patients an...

Ngày tải lên : 20/06/2014, 07:20

8
244
0

báo cáo hóa học:" Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor gene promoter" pptx

... al.: Microarray analysis of Foxl2 mediated gene regulation in the mouse ovary derived KK1 granulosa cell line: Over-expression of Foxl2 leads to activation of the gonadotropin releasing hormone receptor ... resulted in finding a total of 42 genes common to both (Additional file 10) In order to begin to understand the signif...

Ngày tải lên : 20/06/2014, 07:20

12
561
0

Báo cáo y học: "The role of structural genes in the pathogenesis of osteoarthritic disorder" potx

... [23], linkage analysis of 14 candidate genes in OA kindreds resulted in the exclusion of 10 important cartilage genes, including COL2A1 [40] Analysis of 47 families with the phenotype of earlyonset ... epiphyseal dysplasias (MEDs), and the metaphyseal chondrodysplasias They are usually inherited as fully penetrant autosomal dominant disorders The expression of the O...

Ngày tải lên : 09/08/2014, 06:22

9
403
0

Báo cáo y học: "The role of interleukin-1 in the pathogenesis of human Intervertebral disc degeneration" pdf

... staining for phenotypic markers in chondrocyte-like cells from human intervertebral discs Immunohistochemical staining for collagen phenotypic markers in chondrocyte-like cells from human intervertebral ... Suda A: Cathepsin G in degenerating and healthy discal tissue Clin Exp Rheumatol 1999, 17:197-204 Gruber HE, Hanley EN Jr: Analysis of aging and degeneration of the hu...

Ngày tải lên : 09/08/2014, 06:22

14
403
0

Báo cáo y học: "γ The role of the complement and the FcγR system in the pathogenesis of arthritis" pdf

... have resulted in a better understanding of the role of the complement system and FcγRs, although the relative contributions and the hierarchy of these two pathways in the manifestation of disease ... both the FcR and complement system, as part of the innate immune system, are involved in early immune defense and subsequently activate and instr...

Ngày tải lên : 09/08/2014, 06:23

7
476
0

Báo cáo y học: "The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis" potx

... other CFU-M lineage cells because it is expressed solely by cells on the bone The findings supporting a role for osteoclasts in the pathogenesis of peri-implant osteolysis have important clinical ... Research & Therapy Vol No Shen et al Figure Detection of β3 integrin in sections of human peri-implant by immunohistochemistry using a rabbit polyclonal antibody (a, b...

Ngày tải lên : 09/08/2014, 07:20

10
386
0

Báo cáo y học: "Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration" ppt

... study, performed the majority of the laboratory work and analysis, and drafted the manuscript AJF participated in the design of the study and interpretation of data JAH conceived the study, secured ... cells of the aging and degenerating intervertebral disc: immunolocalization of senescence- associated beta-galactosidase in human and sand rat discs Spine 2007,...

Ngày tải lên : 09/08/2014, 10:20

12
617
0

Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt

... expression Finally, we examined the effects of the chemokines on the expression of the cell surface molecules ICOSL, BAFF-R and TACI by peripheral blood B cells of normal donors and sub- Page of 11 ... chemokine receptor expression by peripheral blood in both normal donors and subject...

Ngày tải lên : 09/08/2014, 14:22

11
343
0

báo cáo khoa học: "Co-existence of acute myeloid leukemia with multilineage dysplasia and Epstein-Barr virus-associated T-cell lymphoproliferative disorder in a patient with rheumatoid arthritis: a case report" docx

... factor, anti-RNP antibody, and anti-SS -A antibody Bilateral hand X-rays showed mild swelling and destruction of the metacarpo-phalangeal (MP) and proximal-inter-phalangeal (PIP) joints He was diagnosed ... Hoshida Y, Xu JX, Fujita S, Nakamichi I, Ikeda J, Tomita Y, Nakatsuka S, Tamaru J, Iizuka A, Takeuchi T, Aozasa K: Lymphoproliferative disorders in rheumatoid arthritis:...

Ngày tải lên : 10/08/2014, 22:20

6
314
0