Molecular biology and pathogenesis of coronavirus virus and host factors involved in viral RNA transcription
Molecular biology and pathogenesis of coronavirus virus and host factors involved in viral RNA transcription
... The Biology of Coronavirus 1.1 Overview of Coronaviruses 1.1.1 Taxonomy, genomic and physical properties of Coronaviruses Coronaviruses are a group of enveloped RNA viruses whose genome is in ... (+)mRNA 3’ (+)mRNA Figure 1.5: The transcription of gammacoronavirus IBV produces a nested set of positive-sense mRNAs that are 5'- and 3'- co-terminal (+) gRNA is mRNA1 and mRNAs to are (+) sgRNAs ... Amino acid residues critical for RNA- binding in the N-terminal domain of the nucleocapsid protein are essential determinants for the infectivity of coronavirus in cultured cells Nucleic Acids...
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báo cáo khoa học: " Dissection of genetic and environmental factors involved in tomato organoleptic quality" doc
... biochemical factors are mainly involved in tomato fruit flavour determination Network analysis was able to reduce data complexity by focusing on key information of the full data set A number of links ... contributing to fruit organoleptic quality and to the perception of sensory attributes were identified [21] In order to gain a clearer understanding of the biochemical and genetic control of the ... further 11% of the variability, and consists in the Asn, Ser, Glu and Thr amino acids, and in skin resistance The fifth and sixth factors explained 11% and 8% of total variability, respectively...
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Biotechnology of Microbial Xylanases: Enzymology, Molecular Biology and Application
... clarification of juices, improvement in consistency of beer and the digestibility of animal feed stock Application of xylanase in the saccharification of xylan in agrowastes and agrofoods intensifies ... is to discuss the properties and molecular biology of xylanases, genetics of microorganisms producing xylanases and applications Xylan, one of the major components of hemicelluloses found in plant ... terrestrial plants and accounts for 30% of the cell wall material of annual plants, 15-30% of hard woods and 7-10% of soft woods Xylan is a heteropolysaccharide having O-acetyl, arabinosyl and 4-O-methyl-D-glucuronic...
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Báo cáo y học: " Evolution of Dengue Virus Type 3 Genotype III in Venezuela: Diversification, Rates and Population Dynamics" docx
... found in DENV -3 genotype III of strains circulating in the South American region In order to map the amino acid substitutions found on the E protein structure of DENV -3 genotype III strains of the ... initial years of the introduction in the continent (1994-2000) and strains isolated in the Latin American region in recent years (see Figure 1) In this study, the evolution of DENV -3 genotype III in ... protein 3D structure In order to map amino acid substitutions found in Venezuelan DENV -3 genotype III E protein, crystallography data of the E protein of the strain DENV -3/ TH/ CH 534 89D 73- 1/1973...
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Báo cáo y học: " Factor correction as a tool to eliminate between-session variation in replicate experiments: application to molecular biology and retrovirology" ppsx
... data of the molecular- biology data set from Figure A: original data B: normalised data C: standardised data D: data after factor correction Note that normalisation, standardisation, and factor ... constructs and in the molecular- biology data set is clearly larger after standardisation than after factor correction (cf Figs 2C and 2D) In factor correction, all available data are equally weighted to ... between-session variation in bio-medical research are "normalisation" and "standardisation" [5] In normalisation, a "control" condition is defined and per session all measured values (Yni) are divided by the...
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Excluded volume effects in molecular biology and extracellular matrix biochemistry biophysical considerations and molecular modeling
... Crowding influences Intra-cellular Trafficking 6.4 Macromolecular Crowding on Protein-folding and Stability 6.5 Macromolecular Crowding Effects on Protein-Aggregation 6.6 Macromolecular Crowding Effects ... frequently increasing the binding strength by at least an order of magnitude (Wilf & Minton, 1981) 6.4 Macromolecular Crowding on Protein-folding and Stability Crowding influences protein stability ... Acid Single Strands 83 10.6.2 Mixed MMC greatly enhances DNA-thermal Stabilizing Effects 84 10.6.3 A Combined in vitro -in silico Approach 86 10.6.4 Crowding Effects by Confinement 87 11 Macromolecular...
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Discovery of safe anti dengue virus drugs from libraries of FDA approved drugs and plants through screening against viral RNA dependent RNA polymerase activity
... system-produced NS5 proteins 86 4.3 Screening libraries of FDA- approved drugs and natural compounds 88 4.4 Primary screening of libraries of FDA- approved drugs and natural compounds in in vitro ... for the development of anti- dengue therapeutics In this study, the discovery of antiviral drugs against dengue will be focused upon 21 1.4.1 Ideal characteristics of dengue antiviral drug The development ... why over 60% of anticancer and 75% of anti- infective drugs approved from 1981 - 2002 can be traced back to natural origins (Gupta et al., 2005) The screening of FDA- approved drugs and natural...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... seen in the putative T-box DNA-binding domain of t-bet, the STAT protein interaction domain, STAT protein all-alpha domain, STAT protein DNA-binding domain and SH2 domain of stat6, and the zinc-finger ... implicated in other protein–protein interactions, a STAT protein DNA-binding domain and an SH2 domain, which binds phosphorylated tyrosine residues in the context of a longer peptide motif within a ... expression of these genes within humans and mice, of T-bet within Ginbuna crucian carp [27] and STAT6 in mandarin fish [28] have shown similar widespread expression In the case of STAT6, highest...
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Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
... from the oyster Crassostrea gigas [5] Interestingly, this protein, named C gigas chitinase-like protein (CgClp1) was found to be involved in the control of growth and remodelling processes in a ... composed of the sole Glyco_18 domain, the C-terminal tail of C gigas CLPs may not noticeably contribute to the structure and the function of these proteins Interestingly, Cg-Clp1 and Cg-Clp2 C-terminal ... based on the conserved amino acid sequences of the catalytic domain of members of the GH18 family resulted in the amplification of an expected 147 bp sequence Cloning and sequencing of this fragment...
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Báo cáo khoa học: Studies on the role of the receptor protein motifs possibly involved in electrostatic interactions on the dopamine D1 and D2 receptor oligomerization pdf
... co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R1–YFP – genetic variant of dopamine D2 receptor) d Measured in cell co-expressing dopamine D1 and D2 fusion protein (D1 CFP and D2R2–YFP ... two dopamine D2 receptor fusion proteins (D2 CFP and D2 YFP) f Measured in cell co-expressing two dopamine D2 receptor fusion proteins (D2 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) ... of dopamine D2 receptor) e Measured in cell co-expressing dopamine D1 and D2 fusion proteins (D1 CFP and D2R3–YFP – genetic variant of dopamine D2 receptor) f Measured in cell co-expressing dopamine...
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Báo cáo khoa học: Association of RNA with the uracil-DNA-degrading factor has major conformational effects and is potentially involved in protein folding pot
... suggesting that DNA is able to replace RNA in RNAUDE, in agreement with the overlap of the respective binding sites These ndings can be interpreted within the previously introduced hypothesis that RNAUDE ... abundant in this recombinant overexpression system; domain V of the 23S rRNA, which is known to be involved in assisting de novo protein folding during translation [1416]; and the mRNA of the abundant ... formation is within the translation-coupled folding mechanism, which may involve the presence of both rRNAs and UDE mRNA, and potentially the assistance of domain V of 23S rRNA [14,16] 308 De novo protein...
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Báo cáo khoa học: Sp1 and Sp3 are involved in up-regulation of human deoxyribonuclease II transcription during differentiation of HL-60 cells pptx
... These sites bind Sp1 and Sp3, and protein levels and binding of Sp1 and Sp3 are increased in PMAtreated cells These findings indicate that Sp1 and Sp3 play a pivotal role in the transcriptional ... and Sp3 are able to bind to the GC boxes and that binding of Sp1 forms complex C1 and binding of Sp3 forms complexes C2 and C3 PMA treatment increases Sp1 and Sp3 protein expression in HL-60 cells ... the PMA-induced transcription of lysosomal acid lipase and acid sphingomyelinase in THP-1 cells In this study, we show that Sp1 is involved in PMA-induced expression of DNase II in HL-60 cells...
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Báo cáo khoa học: Cloning and functional characterization of Phaeodactylum tricornutum front-end desaturases involved in eicosapentaenoic acid biosynthesis doc
... organism for cloning the genes encoding the different fatty acid desaturases involved in EPA biosynthesis and identified two sequences coding for fatty acid desaturases with D5- and D6-regioselectivities ... contains 12 acidic amino acids (aspartate and glutamate), whereas the corresponding domain sequences in PtD5p and PtD6p have only eight and five acidic residues, respectively Such a decrease in ... the number of acidic amino acids in fused cytochrome b5 domains has been observed in Fig Amino acid sequences of PtD5p and PtD6p For alignment the CLUSTAL X program was used (gap opening 12, gap...
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