role of oxidative stress in female reproduction reproductive biology and endocrinology

... independ- ent of body mass index (BMI), is responsible for an in- crease in oxLDL [71]. Insulin resistance and/ or compensatory hyperinsulinemia increase the availability of both circulating androgen and androgen ... system also plays a role in female reproduction and fetal development by being involved in cell growth, differentiation, and death. Incorrect protein folding and formation of disulfide bonds can ... JG: Role of oxidative stress in endometriosis. Reprod Biomed Online 2006, 13:126–134. 22. Agarwal A, Gupta S, Sharma RK: Role of oxidative stress in female reproduction. Reprod Biol Endocrinol...

Ngày tải lên: 05/03/2014, 16:20

... majors in enhancing English speaking competence. 49 2.1. Misunderstanding of meaning caused by wrong placement of stress 49 2.2. Misunderstanding of meaning caused by changes in sentence stress. ... distinguish between four levels of stress: major sentence stress, major word stress, minor word stress and unstressed. Thus, in the sentence: “I walked home in the rainstorm”. ‗I‘, in , and ... meaning and none of them denied the role of producing accurate sentence stress. However, a problem, their strong attitude, cognition and utilization sentence stress in enhancing speaking competence...

Ngày tải lên: 17/03/2014, 16:12

... complex leads to the initiation of complex signaling events leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52]. ... [86,91-94]. Levels of both dityrosine and nitrotyrosine are elevated in brain regions specifically affected in AD [91]. Protein nitration is also increased in the hippocampus of AD patients compared ... the inducible nitric oxide synthase (iNOS) [75-77]. Fibrillar Aβ peptides stimulate the induc- tion of iNOS and NO production through an NADPH- dependent oxidative deamination of L-arginine [56,75,78,79]....

Ngày tải lên: 19/06/2014, 22:20

Ngày tải lên: 09/08/2014, 06:22

Ngày tải lên: 12/08/2014, 18:22

... not the terminal trimming of N-glycans is involved in the regulation of the stability and trafficking of GAT1. It has been reported that a variety of molecular chaperones and folding enzymes assist ... substrate binding process. This provides strong evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... ⁄ P i and blocked with 5% bovine serum albumin and 0.1 m glycine in NaCl ⁄ P i for 30 min and washed with NaCl ⁄ P i again. Polyclonal antibod- ies against GAT1 were used for immunostaining at...

Ngày tải lên: 19/02/2014, 17:20

Ngày tải lên: 10/08/2014, 10:20

Ngày tải lên: 12/08/2014, 16:20

... determine the effects of Hsp105a on JNK and p38 signalling pathways, we examined the activation of JNK and p38 in F9 cells by oxidative stress. As shown in Fig. 6A, JNK was not activated in control ... activation of p38 induced by oxidative stress, we further examined whether its activation is responsible for the induction of apoptosis in F9 cells using SB202190, a potent inhibitor of p38. As shown in ... peroxide. In contrast, hydrogen peroxide-treat- ment induced marked activation of JNK within 30 min in S23 cells, but not in S3 cells. Therefore, the enhancement of the oxidative stress- induced...

Ngày tải lên: 21/02/2014, 03:20

... imposing a continuous load of calcium to the neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase ... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... for a role of Trp proteins in the oxidative stress- induced membrane conductances of porcine aortic endothelial cells. Cardiovasc Res 42, 543– 549. 236 Wehage E, Eisfeld J, Heiner I, Jungling E,...

Ngày tải lên: 07/03/2014, 12:20

... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARP activation within 5 min that was inhibited by benzamide. Oxidative ... development. HA-induced oxidative stress activates PARP within 5 min (Fig. 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide. Preincubation of cells ... the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA) to induce in situ generation of H 2 O 2 and monitored the effect of benzamide,...

Ngày tải lên: 23/03/2014, 07:20

... cell activity of several LOX inhibitors, including aesculetin (a nonselective LOX inhibitor), MK886 (an inhibitor of the 5-LOX-activating protein), zileuton (a 5-LOX inhibitor), baicalein (a 12/15-LOX inhibitor), ... [11,12], and pro- mote apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of many antineoplastic agents [13,14]. To investigate whether oxidative stress ... leads to inactivation of MKPs and activation of MAPKs [7-9]. ROS-mediated inhibition of MKPs is critical for TNFα-induced sus- tained activation of JNK and subsequent apoptosis [7]. Interestingly,...

Ngày tải lên: 18/06/2014, 16:20

... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... a subset of NSAIDs (e.g. ibuprofen, flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the dep- osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug- gests...

Ngày tải lên: 19/06/2014, 22:20

... response of the organism to particle-induced oxida- tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat- ing from a response to oxidative ... within-shift variation of 8OHdG (% of initial value) and within-shift reduced species (% of initial value) for smokers and non smokers. Sauvain et al. Journal of Occupational Medicine and Toxicology ... 8OHdG and reducing species. (a) Correlation between urinary levels of 8OHdG ( in μg/g creatinine) and reduced species (in μW/g creatinine) for all collected samples. (b) Correlation between within-shift...

Ngày tải lên: 20/06/2014, 00:20

... C, Becker S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine(PM 2.5 ) and coarse particles(PM 10 - 2.5 ) in outdoor and indoor air. Toxicol Appl Pharmacol ... PM10 suggesting that PM2.5 induced more oxidative stress than PM10. In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total plasmid DNA (form F ig. 10. RT-PCR analysis of ... 11–18 Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim 1 , Yoon-Shin Kim 2 , Nam-Hyun Chung 3 and Myung-Haing Cho* Laboratory...

Ngày tải lên: 07/08/2014, 17:22

Ngày tải lên: 07/08/2014, 18:21

... decreases in GSH levels in our study may be due to either the inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free radicals [33]. The decrease in ... reported in Nilaparvata lugens, a pyrethroid insecticide resistant strain of insect [38]. GST levels were also increased significantly after 30 days of exposure to protect RBCs from oxidative ... significantly reduced (p ＜ 0.05) in all groups compared to the control group. Similar finding have been reported in other study during oxidative stress [24]. No significant changes in GST activity was...

Ngày tải lên: 07/08/2014, 23:22

Ngày tải lên: 08/08/2014, 00:22

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 11/08/2014, 07:21