role of oxidative stress in female reproduction reproductive biology and endocrinology
The effects of oxidative stress on female reproduction: a review ppt
... independ-ent of body mass index (BMI), is responsible for an in- crease in oxLDL [71]. Insulin resistance and/ orcompensatory hyperinsulinemia increase the availability of both circulating androgen and androgen ... system also plays a role in female reproduction and fetal development by being involved in cell growth,differentiation, and death. Incorrect protein folding and formation of disulfide bonds can ... JG: Role of oxidative stress in endometriosis. Reprod Biomed Online 2006, 13:126–134.22. Agarwal A, Gupta S, Sharma RK: Role of oxidative stress in female reproduction. Reprod Biol Endocrinol...
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The role of sentence stress in enhancing english speaking competence of HPU english majors
... majors in enhancing English speaking competence. 49 2.1. Misunderstanding of meaning caused by wrong placement of stress 49 2.2. Misunderstanding of meaning caused by changes in sentence stress. ... distinguish between four levels of stress: major sentence stress, major word stress, minor word stress and unstressed. Thus, in the sentence: “I walked home in the rainstorm”. ‗I‘, in , and ... meaning and none of them denied the role of producing accurate sentence stress. However, a problem, their strong attitude, cognition and utilization sentence stress in enhancing speaking competence...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... complex leads to theinitiation of complex signaling events leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. ... [86,91-94]. Levels of both dityrosine and nitrotyrosine are elevated in brain regions specificallyaffected in AD [91]. Protein nitration is also increased in the hippocampus of AD patients compared ... the inducible nitric oxide synthase(iNOS) [75-77]. Fibrillar Aβ peptides stimulate the induc-tion of iNOS and NO production through an NADPH-dependent oxidative deamination of L-arginine[56,75,78,79]....
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... not the terminaltrimming of N-glycans is involved in the regulation of the stability and trafficking of GAT1. It has beenreported that a variety of molecular chaperones and folding enzymes assist ... substratebinding process. This provides strong evidence thatN-glycans, in particular their terminal structures, areinvolved in regulating the GABA translocation of GAT1, but not in binding of GAT1 ... ⁄ Pi and blocked with 5%bovine serum albumin and 0.1 m glycine in NaCl ⁄ Pifor30 min and washed with NaCl ⁄ Piagain. Polyclonal antibod-ies against GAT1 were used for immunostaining at...
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Tài liệu Báo cáo khoa học: Enhancement of oxidative stress-induced apoptosis by Hsp105a in mouse embryonal F9 cells pptx
... determine theeffects of Hsp105a on JNK and p38 signalling pathways, weexamined the activation of JNK and p38 in F9 cells by oxidative stress. As shown in Fig. 6A, JNK was notactivated in control ... activation of p38 induced by oxidative stress, we further examined whether its activationis responsible for the induction of apoptosis in F9 cells usingSB202190, a potent inhibitor of p38. As shown in ... peroxide. In contrast, hydrogen peroxide-treat-ment induced marked activation of JNK within 30 min in S23 cells, but not in S3 cells. Therefore, the enhancement of the oxidative stress- induced...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... imposing a continuous load of calcium to the neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease ... by proteins resi-ding in both the inner and outer mitochondrialmembrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... for a role of Trp proteins in the oxidative stress- induced membrane conductances of porcineaortic endothelial cells. Cardiovasc Res 42, 543–549.236 Wehage E, Eisfeld J, Heiner I, Jungling E,...
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Báo cáo khoa học: Effect of oxidative stress and involvement of poly(ADP-ribose) polymerase (PARP) in Dictyostelium discoideum development doc
... PARP inhibitor, on oxidative stress- induced changes in D. discoideum development. Interestingly, oxidative stress resulted in PARPactivation within 5 min that was inhibited by benzamide. Oxidative ... development.HA-induced oxidative stress activates PARP within5 min (Fig. 4A,B), and its role during oxidative stress is further confirmed by the use of low concentrations of benzamide. Preincubation of cells ... the response of this organism to oxidative stress and the role of PARP during development. We used hydroxylamine (HA)to induce in situ generation of H2O2 and monitored the effect of benzamide,...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... cellactivity of several LOX inhibitors, including aesculetin (anonselective LOX inhibitor), MK886 (an inhibitor of the5-LOX-activating protein), zileuton (a 5-LOX inhibitor),baicalein (a 12/15-LOX inhibitor), ... [11,12], and pro-mote apoptosis. In fact, ROS-induced oxidative stress and cell death play important roles in the efficacy of manyantineoplastic agents [13,14].To investigate whether oxidative stress ... leads to inactivation of MKPs and activation of MAPKs [7-9]. ROS-mediatedinhibition of MKPs is critical for TNFα-induced sus-tained activation of JNK and subsequent apoptosis [7].Interestingly,...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... a subset of NSAIDs(e.g. ibuprofen, flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the ... that a full dose of indomethacin alone despite a significant reduction in brain inflammation had only a marginal effect on brain oxidative stress in the Tg2576 mice [16]. This finding sug-gests...
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báo cáo hóa học: " Biomarkers of oxidative stress and its association with the urinary reducing capacity in bus maintenance workers" pptx
... response of the organism to particle-induced oxida-tive stress. The observed increase of reducing species in urine would mirror an increased level in blood originat-ing from a response to oxidative ... within-shift variation of 8OHdG (% of initial value) and within-shift reduced species (% of initial value) for smokers and non smokers.Sauvain et al. Journal of Occupational Medicine and Toxicology ... 8OHdG and reducing species. (a) Correlation between urinary levels of 8OHdG ( in μg/g creatinine) and reduced species (in μW/g creatinine) for all collected samples. (b) Correlation between within-shift...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... C, Becker S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposedto fine(PM2.5) and coarse particles(PM10-2.5) in outdoor and indoor air. Toxicol Appl Pharmacol ... PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total plasmid DNA (formFig. 10. RT-PCR analysis of ... 11–18Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... decreases in GSH levels in our study may be due to either the inhibition of GSH synthesis or increased utilization of GSH for detoxification of toxicant induced free radicals [33]. The decrease in ... reported in Nilaparvata lugens, a pyrethroid insecticide resistant strain of insect [38]. GST levels were also increased significantly after 30 days of exposure to protect RBCs from oxidative ... significantly reduced (p ＜ 0.05) in all groups compared to the control group. Similar finding have been reported in other study during oxidative stress [24]. No significant changes in GST activity was...
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