Regulation of substance p and neurokinin 1 receptor expression in a mouse model of acute pancreatitis

... has been identified as a key proinflammatory mediator in experimental acute pancreatitis (AP) SP is a product of the preprotachykinin -A (PPTA) gene, and it binds mainly to neurokinin- 1 receptor ... either an aromatic or an aliphatic amino acid (Severini et al., 2002) Tachykinins are produced by three genes in mammals, namely preprotachykinin A (PPTA), preprotachykini...

Ngày tải lên: 09/09/2015, 17:54

... from the AR+ luminal cell population [9] In other words, AR signalling may be entirely bypassed during the transformation of prostate stem cells into PCSCs [9] Alternatively, AR signalling may remain ... basal /stem cells, supporting that they could be the origin of PCSCs under the influence of persistent Hedgehog overexpression P63+ basal /stem cells were transfo...

Ngày tải lên: 10/08/2014, 05:21

... proliferation and maximal ERa and PR expression in the luminal and glandular epithelium [9], in addition to the Kalpokas et al Acta Veterinaria Scandinavica 2010, 52:66 http://www.actavetscand.com/content/52/1/66 ... any associated glandular atrophy and/ or cystic glandular change Also hypertrophy, nonseasonal endometrial hypoplasia, and lymphatic lacunae were evaluated Page...

Ngày tải lên: 12/08/2014, 18:22

... [7], although kinetic studies [8] indicate that its alanineglyoxylate aminotransferase activity is not favored over aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase ... (p97) cofactor (p47) Aminoacylase Phosphoglycerate mutase Indolethylamine N-methyltransferase Peroxiredoxin Apolipoprotein A- I Abhydrolase domain containing 14b D-Amino Protein na...

Ngày tải lên: 23/03/2014, 03:20

... Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S: Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil ... cell vaccination augments anti-cancer immunity in a mouse model of gastric cancer Journal of Translational Medicine 2011 9:140 Submit your next manuscri...

Ngày tải lên: 18/06/2014, 22:20

... conventional antiemetics, usually in combination, can partially decrease ritonavir-induced nausea and vomiting Ondansetron, a 5-HT3 antagonist, has been used in refractory cases of nausea and vomiting in ... called pica behavior Pica in rats is thus analogous to nausea and vomiting in humans and other species [11,13] Pica in rats is mediated by mechani...

Ngày tải lên: 10/08/2014, 05:21

... microarray-based approaches to examine gene expression and miRNA changes in the brainstem and prefrontal cortex in a mouse facial carrageenan injection model of orofacial pain At the brainstem level, increased ... Inflammatory pain Tissue injury initiates an inflammatory response that induces pain This type of pain is known as inflammatory pain...

Ngày tải lên: 10/09/2015, 08:34

... complicated because of the region’s density of anatomical structures, rich innervations and high vascularity Orofacial pain is defined by the American Academy of Orofacial Pain (AAOP) as pain conditions ... as brushing and touch, are painful (allodynia), and normally mild pain stimuli like pinprick are much more painful than usual (hyperalgesia) Hyperalgesia in the ar...

Ngày tải lên: 14/09/2015, 08:42

... gallamine or alcuronium) Since then an increasing number of allosteric ligands that can decrease or increase in a subtype-specific manner classical muscarinic agonist and antagonist binding affinity ... acts as a retinal neurotransmitter and may interact with dopaminergic mechanisms (Brown and Rietow 19 81) Pharmacological studies of muscarinic agents are interesting and impo...

Ngày tải lên: 16/09/2015, 08:31

... infection and neoplasms Neuralgic pain is generally expressed in the facial area as idiopathic trigeminal neuralgia The ill-defined category of atypical oral and facial pain includes a variety of pain ... hyperalgesia, and in the area of normal tissue surrounding the injury site, as secondary hyperalgesia (c) Phase (Neuropathic Pain) These are abnormal pain states...

Ngày tải lên: 05/10/2015, 13:53

... of adenomatous polyposis coli (APC), somatostatin, carbonic anhydrase and tenascin C in the cerebellum (Figure 1a) and those of lysyl oxidase, carbonic anhydrase 4, enolase 3β and creatine kinase ... sensitive to thyroid hormone and the primary mode of T3 action is a direct influence on cardiac gene expression [20] Increased heart rate (tachycardia) and myocardial contractility...

Ngày tải lên: 09/08/2014, 20:20

... peptides including LANP, VD and KP in modulating lung inflammation In this report we show that overexpression of VD attenuates airway inflammation in a mouse model of allergic asthma The effects of ... determine airway resistance values and peak values obtained after each MeCh challenge were plotted [16] Modulation of lung inflammation by VD To test the eff...

Ngày tải lên: 12/08/2014, 14:20

... (s.e.m.) After log transformation, airway responsiveness to methacholine was statistically analyzed by a general linear model of repeated measurements (ANOVA) followed by a post hoc comparison ... characterized by AHR, induction of specific IgE and airway eosinophilia We show for the first time that AHR is dramatically increased by GITR triggering at the time of alle...

Ngày tải lên: 12/08/2014, 14:20

... 10.1186/ar3062 Cite this article as: Kerachian et al., New insights into the pathogenesis of glucocorticoid-induced avascular necrosis: microarray analysis of gene expression in a rat model Arthritis ... vessels of the femoral head In fact, the vascular hypothesis (regional endothelial bed dysfunction) appears to be relevant in the pathogenesis o...

Ngày tải lên: 12/08/2014, 14:22