chemokine and chemokine receptor expression in infected ganglia

... Access Somatostatin and CXCR4 chemokine receptor expression in hepatocellular and cholangiocellular carcinomas: tumor capillaries as promising targets Daniel Kaemmerer1†, Robin Schindler2†, Franziska ... SSTR3 were detected in about 15%, 8%, and 5% of the HCC tumors, respectively SSTR and CXCR4 expression was much higher in CCC than in HCC CXCR4 and SSTR1 were present in 60% and 67% of the CCC ... Somatostatin receptors, Chemokine receptor, CXCR4, Hepatocellular carcinoma, Cholangiocellular carcinoma Background Hepatocellular carcinomas (HCCs) account for 90% of primary liver tumors and are...

Ngày tải lên: 23/07/2020, 23:51

... genistein Expression of ERα-ERE-luc and ERβ-ERE-luc reporter genes decreased significantly following genistein treatment in high E2 concentrations, and increased significantly following genistein ... treatment in low E2 concentrations Conclusions: Genistein showed estrogen-like effects in endometrial cancer cells and influenced estrogen receptor signaling by EP modulating ERα and ERβ expression ... coordinate changes in MMP-26 and ER expression may occur in endometrial cancers of different pathological stage, and studied the effect of genistein by evaluating expression of both genesin cells...

Ngày tải lên: 04/12/2022, 10:39

... inflammatory site in RA, and the effects of chemokines on B cell activation BAFF-R: B cell-activating factor receptor; BSA: bovine serum albumin; CCL: CC chemokine ligand; CCR: CC chemokine receptor; ... as well as entry into acute and chronic inflammatory sites Expression of chemokines and chemokine receptors in the RA synovial tissue has been extensively analyzed, and chemokines are thought ... H: Chemokines in immunity Adv Immunol 2001, 78:57-110 Jin T, Xu X, Hereld D: Chemotaxis, chemokine receptors and human disease Cytokine 2008, 44:1-8 Koch AE: Chemokines and their receptors in...

Ngày tải lên: 09/08/2014, 14:22

... results. In normal liver tissue, LIF receptor (LIF-R) expression was detected as a continuous sinusoidal staining and in the stroma of portal tracts (Fig. 7A). In the cirrhotic liver, the sinusoidal ... RT-PCR analysis of LIF-M expression in various cell lines and in human liverFigure 6 RT-PCR analysis of LIF-M expression in various cell lines and in human liver. (A): LIF-M expression was analyzed ... remains hypothetical. In the case of s-LIF-D, initiation at the AUG within exon D would result in a reading-frame shift following the 6 th amino-acid (aa) and a termination at aa 88, the resulting...

Ngày tải lên: 13/08/2014, 13:20

... in submandibular glands Double labelling of CD31 and M3R revealed M3R in the wall of blood vessels in submandibular glands of both NOD mice and BALB/c mice (Figure 5a,b) In addition, M3R staining ... M, Sorsa T, Konttinen YT: Distribution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjogren's syndrome and in normal controls Clin Exp Rheumatol 1994, ... neuropeptides in these cells Persisting blood vessels and ducts with innervating NPY fibres could still be detected in the inflammatory infiltrates (Figure 7b) Inflammation of the submandibular glands...

Ngày tải lên: 09/08/2014, 01:22

... pCX-shh-IG injection (arrowheadindicated in (c) and (d), also magnified in the inlets) (C) The pCX-shh-IG-injected prostate tissue sections were stained strongly for Hedgehog protein in PIN and CaP, in ... pCXshh-IG-injected prostates (arrowhead-indicated in (b) and (c)) All luminal cells (arrowhead-indicated in (d)) and some basal cells (arrow (1)indicated in (d)) in the normal prostate expressed AR in ... with tumor initiation and progression in the pCX-shh-IG-injected prostate (arrow-indicated in (b), (c) and (d)), in contrast to the normal P63+ cells in the pCX-IG-injected prostate (indicated...

Ngày tải lên: 10/08/2014, 05:21

... within macaque RV2 rhadinovirus species but not within macaque RV1 rhadinoviruses In this paper, we report the development of a sensitive and specific TaqMan QPCR assay and its use in detecting and ... RRV and the closely related MneRV2 within the RV2 lineage distinct from RFHV and KSHV [5] Although RV2 rhadinoviruses have been identified in all Old World non-human primates tested, including ... [3,4] We and others have demonstrated the existence of two distinct lineages of KSHV-like rhadinoviruses in Old World non-human primates [5,6] The rhadinovirus-1 (RV1) lineage includes KSHV and closely...

Ngày tải lên: 18/06/2014, 22:20

... within macaque RV2 rhadinovirus species but not within macaque RV1 rhadinoviruses In this paper, we report the development of a sensitive and specific TaqMan QPCR assay and its use in detecting and ... RRV and the closely related MneRV2 within the RV2 lineage distinct from RFHV and KSHV [5] Although RV2 rhadinoviruses have been identified in all Old World non-human primates tested, including ... [3,4] We and others have demonstrated the existence of two distinct lineages of KSHV-like rhadinoviruses in Old World non-human primates [5,6] The rhadinovirus-1 (RV1) lineage includes KSHV and closely...

Ngày tải lên: 20/06/2014, 04:20

... further examine the expression of IL-17A in actively inflamed joints and to elucidate the mechanism of IL-17A, alone and in combination with TNF-α and oncostatin M (OSM) in matrix turnover and cartilage ... Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases J Cell Mol Med 2002, 6:357-376 Szekanecz Z, Kim J, Koch AE: Chemokines and chemokine receptors in ... Lubberts E: Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic...

Ngày tải lên: 09/08/2014, 14:22

... Fig 27 Increased NHE1 protein expression level leads to an increase in pHi 90 Fig 28 Silencing of NHE1 gene results in a drop in intracellular pH in NIH3T3 cells 90 Fig 29 Increase in intracellular ... superoxide and induce NHE1 transcription 92 Fig 30 Silencing of NHE1 gene results in a drop in intracellular pH in M14pIRES and M14RacV12 cells 92 Fig 31A Silencing of NHE1 gene results in a drop in intracellular ... and inhibits xIAP (Douglas RG, 2000) In summary, apoptotic machinery consists of a host of proteins interacting with each other in a complex and intricate manner, one group of proteins favoring...

Ngày tải lên: 16/09/2015, 08:31

... another in would contain transgene sequences in 100% of their cells, and the remaining from individuals would be mosaics, consisting of 1/3rd or 2/3rd transgene-containing cells Accordingly, pre-screening ... telomeres and replication origins, and are maintained autonomously within the host cell Structural genes, promoters and enhancers (etc) can be included in MACs Preliminary research indicates ... founder animals integrating and expressing the transgene [51, 52] Transgene uptake and expression following transgenICSI has also been reported in rhesus monkey embryos [53, 54] and porcine embryos...

Ngày tải lên: 03/11/2012, 10:01

... encouraging students to meet and talk with foreigners, obtaining information by designing, asking questions and analyzing their results in a short report? So that, it is very interesting with ... us They told us everything they did in Vietnam and they thought about Vietnam in their travels Therefore, they helped us in getting information for our interview But, in generally, we had not ... Therefore, they spend more time and money for travelling, and for relaxing in some Southern Eastern Asian countries: Thailand, Singapore, Laos, Cambodia, and Vietnam And the reason why the north...

Ngày tải lên: 25/04/2013, 15:42

... N-glycosylation sites in the bovine cation-dependent mannose 6-phosphate receptor: effects on ligand binding, intracellular targetting and association with binding immunoglobulin protein Biochem J 295(Pt ... that in certain cell types HFE acts to regulate intracellular iron levels by decreasing the binding of transferrin to transferrin receptors and reducing cellular iron uptake as a consequence Indeed, ... transferrin receptor reveals overlapping HFE and transferrin binding sites J Mol Biol 313, 385– 397 N-Glycosylation of HFE 22 Lebron JA & Bjorkman PJ (1999) The transferrin receptor binding site...

Ngày tải lên: 06/03/2014, 22:21

... containing HDAC3–GFP ⁄ HDAC4–GFP and ZBP-89–Flag were precipitated by antibodies against GFP and Flag, and they were detected in immunoblots by antibodies against Flag and GFP (Fig 4B), suggesting ... preferentially to CDK4 and CDK6, and prevents their association with D-type cyclins, thus inhibiting retinoblastoma protein phosphorylation and blocking cell cycle progression [10,11] Expression of p16 is ... (siRNA) vector (ZBP-89i) increased expression of p16 and induced cell senescence Moreover, overexpression of HDAC3 and HDAC4 resulted in repression of p16 expression, and HDAC3 was recruited to...

Ngày tải lên: 07/03/2014, 02:20

... 5.0 mm KCl and 10 mm glucose) and incubated for 20 at 37 °C in HBSS containing 1.0 mm calcein ⁄ AM and 1.0 mm cobalt chloride Following cobalt quenching, cultures were washed with HBSS and then ... Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution J Mol Med 81, 678–699 Dobson CM (2004) Principles of protein folding, ... peptides and proteins [27] Much research is currently being carried out into molecules that are able to avoid the appearance of misfolded proteins and their initial aggregates in tissue Notwithstanding...

Ngày tải lên: 16/03/2014, 13:20

... BE (1986) Involvement of finger domain and kringle domain of tissue-type plasminogen activator in fibrin binding and stimulation of activity by fibrin EMBO J 5, 3525–3530 Bakker AH, Weening-Verhoeff ... through its kringle-2 domain, and this interaction is blocked by l-lysine or e-aminocaproic acid as a C-terminal lysine analog [27] The kringle-2 domain of tPA directly interacts with e-aminocaproic ... activator, tPA binds to some membrane proteins, including annexin II [41] The binding of tPA or urokinase-type plasminogen activator to the membrane receptors greatly increases plasminogen activator...

Ngày tải lên: 17/03/2014, 17:20

... annexin IV Fig ANX4 is up-regulated in CCA cell lines Protein and RNA were extracted from two CCA (OVTOKO and OVISE) cells lines and one non-CCA (MCAS) cell line, and then ANX4 protein (A) and ... significantly higher in CCA than non-CCA cell lines and tissues [13] We confirmed this finding by western blotting and real-time RT-PCR analyses using cell lines originating from CCA, OVTOKO and OVISE cultured ... the putative binding sequences for NF-jB and p53 In +180 mutA, both binding sequences were disrupted In +180 mutB, the p53-binding sequence was disrupted, whereas the NF-jB-binding sequence had...

Ngày tải lên: 22/03/2014, 16:20

... future, pioneering the development and provision of relevant training in our Institutes and Centres and working in partnership where possible - Maintain our current investment in training schemes ... current deficit in clinician scientists working at the translational interface and in cancer surgery and pathology Our Centres and Institutes will play a key role in this training, balancing the experience ... promising This optimism is fuelled by the ever-increasing knowledge and understanding of the disease that research provides and in which Cancer Research UK is leading, both in this country and internationally...

Ngày tải lên: 22/03/2014, 16:21

... regions containing Sp1 or AP-2a binding elements in the KCTD10 promoter, and representative ChIP-PCR results were shown in Fig The chromatin fragment containing Sp1- or AP-2a-binding sites in the KCTD10 ... The protein expressions of AP-2a, Sp1 and KCTD10 after overexpressing Ap-2a or Sp1, or suppressing AP-2a or Sp1 by RNA interference in HeLa cells were examined using western blotting b-Actin was ... element binding protein-1 (B) Alignment of the 5¢-flanking sequences upstream of the start codon of human and mouse KCTD10 B Fig In vivo ChIP assays of Sp1.1 and AP-2.2 binding sites in the proximal...

Ngày tải lên: 30/03/2014, 02:20