chemokine and chemokine receptor expression in infected ganglia
Báo cáo sinh học: " Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" docx
Ngày tải lên :
18/06/2014, 22:20
... within macaque RV2 rhadinovirus species but not within macaque RV1 rhadinoviruses In this paper, we report the development of a sensitive and specific TaqMan QPCR assay and its use in detecting and ... RRV and the closely related MneRV2 within the RV2 lineage distinct from RFHV and KSHV [5] Although RV2 rhadinoviruses have been identified in all Old World non-human primates tested, including ... [3,4] We and others have demonstrated the existence of two distinct lineages of KSHV-like rhadinoviruses in Old World non-human primates [5,6] The rhadinovirus-1 (RV1) lineage includes KSHV and closely...
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báo cáo hóa học:" Development of a real-time QPCR assay for the detection of RV2 lineage-specific rhadinoviruses in macaques and baboons" pot
Ngày tải lên :
20/06/2014, 04:20
... within macaque RV2 rhadinovirus species but not within macaque RV1 rhadinoviruses In this paper, we report the development of a sensitive and specific TaqMan QPCR assay and its use in detecting and ... RRV and the closely related MneRV2 within the RV2 lineage distinct from RFHV and KSHV [5] Although RV2 rhadinoviruses have been identified in all Old World non-human primates tested, including ... [3,4] We and others have demonstrated the existence of two distinct lineages of KSHV-like rhadinoviruses in Old World non-human primates [5,6] The rhadinovirus-1 (RV1) lineage includes KSHV and closely...
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Báo cáo y học: "Human rheumatoid arthritis tissue production of IL-17A drives matrix and cartilage degradation: synergy with tumour necrosis factor-α, Oncostatin M and response to biologic therapies" ppt
Ngày tải lên :
09/08/2014, 14:22
... further examine the expression of IL-17A in actively inflamed joints and to elucidate the mechanism of IL-17A, alone and in combination with TNF-α and oncostatin M (OSM) in matrix turnover and cartilage ... Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases J Cell Mol Med 2002, 6:357-376 Szekanecz Z, Kim J, Koch AE: Chemokines and chemokine receptors in ... Lubberts E: Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic...
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Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
Ngày tải lên :
16/09/2015, 08:31
... Fig 27 Increased NHE1 protein expression level leads to an increase in pHi 90 Fig 28 Silencing of NHE1 gene results in a drop in intracellular pH in NIH3T3 cells 90 Fig 29 Increase in intracellular ... superoxide and induce NHE1 transcription 92 Fig 30 Silencing of NHE1 gene results in a drop in intracellular pH in M14pIRES and M14RacV12 cells 92 Fig 31A Silencing of NHE1 gene results in a drop in intracellular ... and inhibits xIAP (Douglas RG, 2000) In summary, apoptotic machinery consists of a host of proteins interacting with each other in a complex and intricate manner, one group of proteins favoring...
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Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
Ngày tải lên :
03/11/2012, 10:01
... another in would contain transgene sequences in 100% of their cells, and the remaining from individuals would be mosaics, consisting of 1/3rd or 2/3rd transgene-containing cells Accordingly, pre-screening ... telomeres and replication origins, and are maintained autonomously within the host cell Structural genes, promoters and enhancers (etc) can be included in MACs Preliminary research indicates ... founder animals integrating and expressing the transgene [51, 52] Transgene uptake and expression following transgenICSI has also been reported in rhesus monkey embryos [53, 54] and porcine embryos...
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DEVELOPING, USING AND ANALYZING THE RESULTS OF INTERVIEWS TO DETERMINE THE FEELINGS OF FOREIGN TOURISTS ON THEIR VISIT TO VIET NAM
Ngày tải lên :
25/04/2013, 15:42
... encouraging students to meet and talk with foreigners, obtaining information by designing, asking questions and analyzing their results in a short report? So that, it is very interesting with ... us They told us everything they did in Vietnam and they thought about Vietnam in their travels Therefore, they helped us in getting information for our interview But, in generally, we had not ... Therefore, they spend more time and money for travelling, and for relaxing in some Southern Eastern Asian countries: Thailand, Singapore, Laos, Cambodia, and Vietnam And the reason why the north...
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Trắc nghiệm tổng hợp vecto-10
Ngày tải lên :
20/07/2013, 01:27
... u u u u uu u u uu u u ur ur ur u r 31/ Cho điểm A, B, C, D, E, F Để chứng minh : AD + BE + CF = AE + BF + CD Một học sinh tiến hành sau : u r ur u u u u uu u u u u uu u r u u u u ur ur ur ur u ... ur ur uu uu uu uu ur ur ur ur ur a GA + GC + GD = BD b GA + GC + GD = DB GV Biên soạn :Cao Thọ Ninh ĐỀ KIỂM TRA TRẮC NGHIỆM HÌNH HỌC LỚP 10 uu uu uu r ur ur ur uu uu uu uu ur ur ur ur c GA + GC ... M trung điểm AB N điểm cạnh AC cho : điểm MN Khi : NC = 2NA Gọi K trung GV Biên soạn :Cao Thọ Ninh ĐỀ KIỂM TRA TRẮC NGHIỆM HÌNH HỌC LỚP 10 ur uu uu uu ur ur a AK = AB + AC ur ur ur uu uu uu ur...
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A New Technique Using Headspace Gas Monitoring to Determine Carbon Source Addition in a BNR Process
Ngày tải lên :
05/09/2013, 08:40
... observed but in this study, its accumulation was not severe Foaming had to be eliminated during the testing, to prevent the gas been trapped and affecting the CO2 profiles The carrier gas sparging rate ... resulting in this delay However, according to ORP and pH profiles, this time lag seemed to be consistent and it did not have a significant effect on the determination of the “E Time” defined in ... The nitrogen flow rate was maintained at 1,200 mL/min in the experiment reactor In each batch test, a certain volume of sodium acetate (1,000 mg/L as HAc) was added and the carbon dioxide profiles...
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Use of an extension of the park's transformation to determine control laws applied to a non sinusoidal permanent magnet synchronous motor
Ngày tải lên :
03/01/2014, 19:50
... 3rd International Conference on Power Electronics and Variable-Speed Drives C Marchand, A Razek, "Electromagnetic Modelling to Optimise Low Speed and Position Control in Servo Motor", I id c t Intamtianal ... @Im is near of its minimal value -@I, and not supplied during the x 60" other interval of the electrical position [ 11 Only two phases are then supplied in the same time and the torque can be ... io* Using Concordia's transformation, the three-phase synchronous drive with sinusoidal back-electromotive force is so reduce to a two-phase system in the "a-p" kame For a non-sinusoidal machine...
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Báo cáo khoa học: N-Glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding pptx
Ngày tải lên :
06/03/2014, 22:21
... N-glycosylation sites in the bovine cation-dependent mannose 6-phosphate receptor: effects on ligand binding, intracellular targetting and association with binding immunoglobulin protein Biochem J 295(Pt ... that in certain cell types HFE acts to regulate intracellular iron levels by decreasing the binding of transferrin to transferrin receptors and reducing cellular iron uptake as a consequence Indeed, ... transferrin receptor reveals overlapping HFE and transferrin binding sites J Mol Biol 313, 385– 397 N-Glycosylation of HFE 22 Lebron JA & Bjorkman PJ (1999) The transferrin receptor binding site...
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Báo cáo khoa học: The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence doc
Ngày tải lên :
07/03/2014, 02:20
... containing HDAC3–GFP ⁄ HDAC4–GFP and ZBP-89–Flag were precipitated by antibodies against GFP and Flag, and they were detected in immunoblots by antibodies against Flag and GFP (Fig 4B), suggesting ... preferentially to CDK4 and CDK6, and prevents their association with D-type cyclins, thus inhibiting retinoblastoma protein phosphorylation and blocking cell cycle progression [10,11] Expression of p16 is ... (siRNA) vector (ZBP-89i) increased expression of p16 and induced cell senescence Moreover, overexpression of HDAC3 and HDAC4 resulted in repression of p16 expression, and HDAC3 was recruited to...
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Báo cáo khoa học: Differing molecular mechanisms appear to underlie early toxicity of prefibrillar HypF-N aggregates to different cell types potx
Ngày tải lên :
16/03/2014, 13:20
... 5.0 mm KCl and 10 mm glucose) and incubated for 20 at 37 °C in HBSS containing 1.0 mm calcein ⁄ AM and 1.0 mm cobalt chloride Following cobalt quenching, cultures were washed with HBSS and then ... Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution J Mol Med 81, 678–699 Dobson CM (2004) Principles of protein folding, ... peptides and proteins [27] Much research is currently being carried out into molecules that are able to avoid the appearance of misfolded proteins and their initial aggregates in tissue Notwithstanding...
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Báo cáo Y học: Matrilysin (matrix metalloprotease-7) cleaves membrane-bound annexin II and enhances binding of tissue-type plasminogen activator to cancer cell surfaces docx
Ngày tải lên :
17/03/2014, 17:20
... BE (1986) Involvement of finger domain and kringle domain of tissue-type plasminogen activator in fibrin binding and stimulation of activity by fibrin EMBO J 5, 3525–3530 Bakker AH, Weening-Verhoeff ... through its kringle-2 domain, and this interaction is blocked by l-lysine or e-aminocaproic acid as a C-terminal lysine analog [27] The kringle-2 domain of tPA directly interacts with e-aminocaproic ... activator, tPA binds to some membrane proteins, including annexin II [41] The binding of tPA or urokinase-type plasminogen activator to the membrane receptors greatly increases plasminogen activator...
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Báo cáo khoa học: Wild-type p53 enhances annexin IV gene expression in ovarian clear cell adenocarcinoma docx
Ngày tải lên :
22/03/2014, 16:20
... annexin IV Fig ANX4 is up-regulated in CCA cell lines Protein and RNA were extracted from two CCA (OVTOKO and OVISE) cells lines and one non-CCA (MCAS) cell line, and then ANX4 protein (A) and ... significantly higher in CCA than non-CCA cell lines and tissues [13] We confirmed this finding by western blotting and real-time RT-PCR analyses using cell lines originating from CCA, OVTOKO and OVISE cultured ... the putative binding sequences for NF-jB and p53 In +180 mutA, both binding sequences were disrupted In +180 mutB, the p53-binding sequence was disrupted, whereas the NF-jB-binding sequence had...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx
Ngày tải lên :
22/03/2014, 16:21
... future, pioneering the development and provision of relevant training in our Institutes and Centres and working in partnership where possible - Maintain our current investment in training schemes ... current deficit in clinician scientists working at the translational interface and in cancer surgery and pathology Our Centres and Institutes will play a key role in this training, balancing the experience ... promising This optimism is fuelled by the ever-increasing knowledge and understanding of the disease that research provides and in which Cancer Research UK is leading, both in this country and internationally...
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Báo cáo khoa học: Transcription factor specificity protein 1 (SP1) and activating protein 2a (AP-2a) regulate expression of human KCTD10 gene by binding to proximal region of promoter pot
Ngày tải lên :
30/03/2014, 02:20
... regions containing Sp1 or AP-2a binding elements in the KCTD10 promoter, and representative ChIP-PCR results were shown in Fig The chromatin fragment containing Sp1- or AP-2a-binding sites in the KCTD10 ... The protein expressions of AP-2a, Sp1 and KCTD10 after overexpressing Ap-2a or Sp1, or suppressing AP-2a or Sp1 by RNA interference in HeLa cells were examined using western blotting b-Actin was ... element binding protein-1 (B) Alignment of the 5¢-flanking sequences upstream of the start codon of human and mouse KCTD10 B Fig In vivo ChIP assays of Sp1.1 and AP-2.2 binding sites in the proximal...
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Báo cáo khoa học: Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function doc
Ngày tải lên :
30/03/2014, 10:20
... 1–174 of the N-terminal domain and retains full enzyme activity in vitro The enzyme contains a central DNA-binding core domain and a C-terminal catalytic domain harboring an SKINYL motif The crystal ... the in vitro reconstitution of the two recombinant proteins LdTOPIL and LdTOPIS, corresponding to the large and small subunits, and localization of the active enzyme in both the nucleus and kinetoplast ... architecture facilitates the opening and closing of the protein clamp during binding and release of DNA [11,12] Champoux and his group have previously reported their findings on human topoisomerase...
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introduction to p-adic numbers and p-adic analysis - a. baker
Ngày tải lên :
31/03/2014, 15:19
... 1/p and so the p-adic number (α − α0 )/p is in Zp Repeating the last step, we obtain an integer α1 satisfying |α − (α0 + α1 p)|p < , p α1 (p − 1) Again repeating this, we find a sequence of integers ... following example Example 1.19 Let a, b ∈ Z with n > Then (1.1) ax ≡ b n is a linear modular equation or linear congruence over Z We are interested in finding all solutions of Equation (1.1) in Z, ... Chinese Remainder Theorem) Let n1 , n2 , , nk be a sequence of coprime integers, a1 , a2 , , ak a sequence of integers satisfying gcd(ai , ni ) = and b1 , b2 , , bk be sequence of integers...
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