Single DNA studies of architectural proteins involved in bacterial pathogenesis and meiosis in saccharomyces cerevisiae

... protein molecules and their interactions with DNA in real-time reactions and the dynamics of their DNA- binding Therefore, my objective of finding the characteristics of protein binding to single DNA ... crucial role in meiosis; it synapses DNA into a stable formation in a zinc dependent manner Overall, my studies have provided important insight of four DNA bin...

Ngày tải lên: 09/09/2015, 11:25

... mediated by a TRIM5-Cyclophilin A fusion protein generated by retroposition [28] Evolutionary analysis of PPIA indicates that Cyclophilin A has been preserved by strong purifying selection, leaving ... interdisciplinary research from the Faculty of Biology and Medicine of the University of Lausanne (to A.T and H.K.) References Yang Z: The power of phylogenetic comparison in reveal...

Ngày tải lên: 13/08/2014, 09:21

... STRUCTURAL AND FUNCTIONAL ANALYSIS OF CRITICAL PROTEINS INVOLVED IN mRNA DECAY CHENG ZHIHONG (B.Sc) Ease China University of Science and Technology A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... deadenylation, decapping and degradation of the mRNA body Three proteins, hUpf1, Dhh1 and Ski8 involved in eukaryotic mRNA decay were structurally and f...

Ngày tải lên: 14/09/2015, 22:22

... repeated over 100 random trials, in which the interactions of both networks are reassigned while maintaining the same number of interactions per protein, resulting in a distribution of random subnetwork ... simple cutoff in the number of interactions Genetic interactions are usually robust, so the distinction by interaction number is less critical Protein interactions on the...

Ngày tải lên: 06/08/2014, 18:21

... 2011 Genome-destabilizing and Mutagenic Effects of Break-induced Replication in Saccharomyces cerevisiae Major Professor: Cynthia V Stauffacher DNA suffers constant damage, leading to a variety of ... GENOME-DESTABILIZING AND MUTAGENIC EFFECTS OF BREAKINDUCED REPLICATION IN SACCHAROMYCES CEREVISIAE A Dissertation Submitted to the Faculty of Purdue Uni...

Ngày tải lên: 24/08/2014, 11:07

... domains for its adaptor function, the importin b binding (IBB) domain in its N-terminus and the C-terminal NLSbinding domain In the absence of importin b, an auto-inhibiting part of the IBB domain ... in maintenance of the normal homeostatic function of cells We identified and characterized two types of monopartite nuclear localization sequences of D melanogaster prote...

Ngày tải lên: 15/03/2014, 11:20

... proteins where zinc is complexed through four invariant cysteine and/or histidine residues, forming a zinc finger domain that is mostly involved in DNA binding but also in protein–protein interactions ... the coupling of zinc- binding structures (either in MT or in zinc finger proteins) by selenium compounds with the cellular redox system GSH/GSSG, reducibl...

Ngày tải lên: 30/03/2014, 15:20

... GBD-hCdt1 binds strongly with RID-hGeminin - 67 3.7 Crystallization of Cdt1 /Geminin complex .- 68 Chapter4 Discussions - 71 4.1 Identifying the Geminin Binding Domain of hCdt1 ... ORC CDT1 Pre-RC S phase (Activation) CDKs Geminin (Licensing) Figure2.1 DNA replication licensing control by Geminin and CDKs during the cell cycle In metazoa, Geminin, present from the onset ......

Ngày tải lên: 04/10/2015, 10:24

... activity is in agreement with the alignment data, which suggest that an intact N-terminal domain is necessary for topoisomerase I activity Topoisomerase activity of HNBB-modified M .Msp I Determination ... that of other m5C-MTases The additional DNA-modifying activity (topoisomerase activity) possessed by M.MspI would require a different type of interaction...

Ngày tải lên: 24/03/2014, 00:21

... http://www.translational-medicine.com/content/7/1/75 Figure Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic Pathways Protein Tyrosine Kinase and other Major Kinases involved in Angiogenic ... serine-threonine kinases, lipid kinases, adhesion molecules and other diffusible signaling proteins The abundance of multiple PTKs and other kinase...

Ngày tải lên: 18/06/2014, 15:20

... article as: Haseneyer et al.: DNA polymorphisms and haplotype patterns of transcription factors involved in barley endosperm development are associated with key agronomic traits BMC Plant Biology ... Carbonero P: An endospermspecific DOF protein from barley, highly conserved in wheat, binds to and activates transcription from the prolamin-box of a...

Ngày tải lên: 12/08/2014, 03:21

... this article as: Bussone et al.: Identification of < /b> new < /b> autoantibody < /b> specificities < /b> directed < /b> at < /b> proteins < /b> involved < /b> in < /b> the < /b> transforming < /b> growth < /b> factor < /b> b pathway in < /b> patients with systemic sclerosis ... 4) Thus, the < /b> expression of < /b> these proteins < /b> can be either increased or d...

Ngày tải lên: 12/08/2014, 15:23

... to total concentrations of multiple indoor air pollutants It is used as a complementary indicator to decrease indoor pollution level in total and achieve healthy indoor air environment. 109) The ... determination and the comparison of their value Indoor Environ., 11, 1–9 (in Japanese) Fukutomi, Y., Yasuda, H., Nakazawa, T., Taniguchi, M and Akiyama, K (20...

Ngày tải lên: 17/02/2014, 22:20

... Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (199 9) Dual targeting property of the N-terminal signal sequence of P450 1A1 Targeting of heterologous proteins to ... open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP 1A1 requiring N-terminal truncation, w...

Ngày tải lên: 18/02/2014, 16:20

... to the 9th cycle from the N-terminus including the initiating Met: MHKTHSTMS for Sno1p and MTGEDFKIKS for Snz1p Properties of the complex of Sno1p and Snz1p When Sno1p with a His-tag and Snz1p ... SNO3, SNZ2 and SNZ3 complement the defect The relationship of all of these genes remains to be clarified Expression and purification of Sno1p and Snz1p In light...

Ngày tải lên: 19/02/2014, 12:20