Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)

... protection pathways in APAP- and H2O2 -induced liver injury in TAMH cells 156 Figure 44 Combination therapy of exosomes and -T3 in APAP- and H2O 2induced liver injury in TAMH cells ... virally -induced disease predominated in early 90s but has substantially declined in the past few years, with most acute injury cases now arising from drug induced- liver...

Ngày tải lên: 09/09/2015, 11:21

... mesenchymal stem cells; HD: hematopoietic differentiated cells; AIDS: acquired immune deficiency syndrome; HAART: highly active anti-retroviral therapy; HPCs: hematopoietic progenitor cells; ... established as to how these mesenchyme derived cells become susceptible to HIV-1 and whether their HIV-1 production rates are comparable to that observed in HIV-1 infected l...

Ngày tải lên: 13/08/2014, 01:20

... as: Chen et al.: Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction Journal of Translational ... adipose-derived mesenchymal stem cells (ADMSCs) After culturing for 14 days, majority of isolated adipose-derived stem cells expressing CD29 and CD90 character...

Ngày tải lên: 18/06/2014, 19:20

... article as: Tsai et al.: Overexpression of hTERT increases stemlike properties and decreases spontaneous differentiation in human mesenchymal stem cell lines Journal of Biomedical Science 2010 ... such as Oct4 and Nanog is associated with differentiation of neural stem cells, hematopoietic stem cells and MSCs However, an increase in Oct4 expressio...

Ngày tải lên: 10/08/2014, 05:21

... Expression of genes in the BMP2+ cells associated with plasticity, and mesodermal and NCSC phenotypes BMP2+ cells are still in a state of plasticity BMP2+ cells significantly upregulate Oct4 and Nanog ... 50 µm 20 µm Analysis neural crest stem cell associated transcripts in BMP2+ cells Figure of Analysis of neural crest stem cell associated transcripts in...

Ngày tải lên: 14/08/2014, 08:20

... of stem cells is a promising method for cartilage repair, in this chapter I confirmed that engraftment of the MSCs in injured cartilage is an active migration and homing process and injured cartilage ... microfracture (265, 266), or introducing new cell sources like debrided waste chondrocytes, Bone Marrow derived Mesenchymal Stem Cells (BM MSCs), or any combinati...

Ngày tải lên: 10/09/2015, 09:01

... HUMAN EMBRYONIC STEM CELL- DERIVED NEURAL STEM CELLS: DERIVATION, DIFFERENTIATION AND MICRORNA REGULATION KWANG WEI XIN TIMOTHY (B.Sc (Hons), NUS) ... mechanisms of regulation of NSC differentiation 1.1.5.2 Pluripotent stem cell- derived NSCs Human embryonic stem cells (hESCs), which are pluripotent cells derived from the inner cell mass of blast...

Ngày tải lên: 10/09/2015, 09:08

...   1. 5 Types of stem cells 14   1. 5 .1 Embryonic stem cells (ESCs) 15   1. 5.2 Induced pluripotent stem (iPS) cells 15   1. 5.3 Adult stem cells 16   1. 5.4 Heterologous stem cells 17   1. 6 MSCs in ... 1. 10.3 Iron Oxide Particles 24   1. 11 Cellular MRI 24   1. 11. 1 Cellular Imaging with Iron Oxide Particles 25   1. 11. 2 Mechanisms of Cellular Uptake 28   1....

Ngày tải lên: 10/09/2015, 09:10

... determined using 0.3% oil red O stain for 15 minutes at room temperature to stain intracellular lipids, and counterstained with hematoxylin Osteogenic differentiation was evaluated using Alizarin ... staining of the harvested tissues (197) 55   Table 3-1 Histological grading scale for cartilage repair (Adapted from (51)) Category Points Cell morphology Hyaline cartilage Mostly hyaline...

Ngày tải lên: 10/09/2015, 09:10

... Oil red O staining demonstrated that unlabeled and labeled cells exhibited no difference in developing fat vacuoles (Figure 3. 9) 64     Figure 3- 9 Oil red O staining Oil red O staining of the ... (F) 3. 4.6.2 Osteogenic differentiation Alizarin red staining showed that MSCs labeled with SPIO did not affect osteogenic differentiation capacity of cells (figure 3. 10)   Figure 3- 10 Ali...

Ngày tải lên: 10/09/2015, 09:11

... labeled cells in the knee joint) MSCs were distributed in different places of the knee (figure 3. 14) The labeled cells migrated to different locations over time including cartilage defect, injection ... MSCs in the mini-pig knee joint The labeled cells migrated to the para-patellar fat tissue (A) and surgical scar in the skin (B) 3 .4. 8 Postmortem analysis Histological grading sco...

Ngày tải lên: 10/09/2015, 09:11

Ngày tải lên: 10/09/2015, 09:11

... confirming the report of Jing et al (2 06, 207) In addition, our results showed that we could detect labeled cells in vivo up to weeks, thus the SPIO labeling method of the cells can be a promising ... labeling concentration of MSCs can reduce the adverse effects of the iron particles Our results showed, after optimized labeling, that visualization of injected MSCs is indeed feasible in...

Ngày tải lên: 10/09/2015, 09:11

... articular cartilage provides only a limited capacity of self -repair Cell based therapy is one promising approach in the treatment of damaged cartilage Bone marrow (BM) derived mesenchymal stem cell (MSC) ... Leukemia inhibitory factor Neurotrophin Chemokine (C-X-C motif) ligand 10 Colony stimulating factor (gran-macrophage) Colony stimulating factor (granulocyte) I...

Ngày tải lên: 10/09/2015, 09:11