Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
Exploring mesenchymal stem cell derived exosome and tocotrienol (t3) as therapeutic agents in drug induced liver injury (DILI)
... protection pathways in APAP- and H2O2 -induced liver injury in TAMH cells 156 Figure 44 Combination therapy of exosomes and -T3 in APAP- and H2O 2induced liver injury in TAMH cells ... virally -induced disease predominated in early 90s but has substantially declined in the past few years, with most acute injury cases now arising from drug induced- liver injury (DILI) [7] In the ... Chapter Introduction 1.1 Liver injury and its pattern 1.2 Clinical outcomes of drug- induced liver injury 1.3 Mechanism of liver injury 1.3.1 General drug- induced liver...
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Báo cáo y học: "Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection" pptx
... mesenchymal stem cells; HD: hematopoietic differentiated cells; AIDS: acquired immune deficiency syndrome; HAART: highly active anti-retroviral therapy; HPCs: hematopoietic progenitor cells; ... established as to how these mesenchyme derived cells become susceptible to HIV-1 and whether their HIV-1 production rates are comparable to that observed in HIV-1 infected lymphoid or myeloid cells Importantly, ... HD-HIV cells versus un-infected HD cells The gene profile of HD-HIV cells was then compared to HUT78-HIV cells The analysis showed that HIV-1 infection altered gene expression within HD cells...
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Báo cáo sinh học: "Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction" ppt
... as: Chen et al.: Adipose-Derived Mesenchymal Stem Cell Protects Kidneys against Ischemia-Reperfusion Injury through Suppressing Oxidative Stress and Inflammatory Reaction Journal of Translational ... adipose-derived mesenchymal stem cells (ADMSCs) After culturing for 14 days, majority of isolated adipose-derived stem cells expressing CD29 and CD90 characteristic of mesenchymal stem cells (n = 3) Note ... tissue mesenchymal stem cells after transplantation into mice with liver injury Stem Cells 2008, 26:2705-2712 Sun CK, Zhang XY, Zimmermann A, Davis G, Wheatley AM: Effect of ischemia-reperfusion injury...
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Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines ppt
... article as: Tsai et al.: Overexpression of hTERT increases stemlike properties and decreases spontaneous differentiation in human mesenchymal stem cell lines Journal of Biomedical Science 2010 ... such as Oct4 and Nanog is associated with differentiation of neural stem cells, hematopoietic stem cells and MSCs However, an increase in Oct4 expression in ESCs causes differentiation into primitive ... with expanded hMSCs, we found that ectopic expression of HPV 16 E6E7 and hTERT enhanced proliferation and stem- like properties, and blocked spontaneous differentiation in primary culture of hMSCs...
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Báo cáo y học: "Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning" ppt
... Expression of genes in the BMP2+ cells associated with plasticity, and mesodermal and NCSC phenotypes BMP2+ cells are still in a state of plasticity BMP2+ cells significantly upregulate Oct4 and Nanog ... 50 µm 20 µm Analysis neural crest stem cell associated transcripts in BMP2+ cells Figure of Analysis of neural crest stem cell associated transcripts in BMP2+ cells (a) RT-PCR analysis for the ... 20 µm Analysis adipocyte and macrophage associated markers in BMP2+ cells Figure of Analysis of adipocyte and macrophage associated markers in BMP2+ cells (a) RT-PCR analysis of adipocyte specific...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 10
... of stem cells is a promising method for cartilage repair, in this chapter I confirmed that engraftment of the MSCs in injured cartilage is an active migration and homing process and injured cartilage ... microfracture (265, 266), or introducing new cell sources like debrided waste chondrocytes, Bone Marrow derived Mesenchymal Stem Cells (BM MSCs), or any combination of these cells (29, 214, 215, 267, ... exogenous stem cells (endogenous from the bone marrow and exogenous by multiple intra -articular injection of the expanded autologous stem cells) As I showed, in the previous chapter, that injection...
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Human embryonic stem cell derived neural stem cells derivation, differentiation and MicroRNA regulation
... HUMAN EMBRYONIC STEM CELL- DERIVED NEURAL STEM CELLS: DERIVATION, DIFFERENTIATION AND MICRORNA REGULATION KWANG WEI XIN TIMOTHY (B.Sc (Hons), NUS) ... mechanisms of regulation of NSC differentiation 1.1.5.2 Pluripotent stem cell- derived NSCs Human embryonic stem cells (hESCs), which are pluripotent cells derived from the inner cell mass of blastocyst-stage ... of Human Embryonic Stem Cells in mTeSRTM1” (STEMCELL Technologies Inc.) In brief, H1 hESCs were maintained on BD matrigel hESC-qualified matrix (BD Biosciences) with mTeSRTM1 medium (STEMCELL...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 1
... 1. 5 Types of stem cells 14 1. 5 .1 Embryonic stem cells (ESCs) 15 1. 5.2 Induced pluripotent stem (iPS) cells 15 1. 5.3 Adult stem cells 16 1. 5.4 Heterologous stem cells 17 1. 6 MSCs in ... 1. 10.3 Iron Oxide Particles 24 1. 11 Cellular MRI 24 1. 11. 1 Cellular Imaging with Iron Oxide Particles 25 1. 11. 2 Mechanisms of Cellular Uptake 28 1. 12 Cell migration 30 1. 12 .1 Stem cell ... in cartilage repair 17 1. 7 Monitoring of Cell Therapy 18 1. 8 Histological Methods 19 1. 9 Imaging Modalities 19 1. 10 Contrast agents 22 1. 10 .1 T1 Contrast Agents (Table 1- 7) 23 1. 10.2...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 2
... determined using 0.3% oil red O stain for 15 minutes at room temperature to stain intracellular lipids, and counterstained with hematoxylin Osteogenic differentiation was evaluated using Alizarin ... staining of the harvested tissues (197) 55 Table 3-1 Histological grading scale for cartilage repair (Adapted from (51)) Category Points Cell morphology Hyaline cartilage Mostly hyaline cartilage ... concentration in the culture media would increase the intracellular iron content of MSCs 61 Average iron content per cell (pg /cell) 20 0 150 100 50 Average iron content per cell (pg /cell) 0µg/ ml 25 µg/...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 3
... Oil red O staining demonstrated that unlabeled and labeled cells exhibited no difference in developing fat vacuoles (Figure 3. 9) 64 Figure 3- 9 Oil red O staining Oil red O staining of the ... (F) 3. 4.6.2 Osteogenic differentiation Alizarin red staining showed that MSCs labeled with SPIO did not affect osteogenic differentiation capacity of cells (figure 3. 10) Figure 3- 10 Alizarin ... (F) 65 3. 4.6 .3 Chondrogenic differentiation Immunohistochemical staining after high density pellet culturing showed that the distribution of collagen type II in extracellular matrix of cells was...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 4
... labeled cells in the knee joint) MSCs were distributed in different places of the knee (figure 3. 14) The labeled cells migrated to different locations over time including cartilage defect, injection ... MSCs in the mini-pig knee joint The labeled cells migrated to the para-patellar fat tissue (A) and surgical scar in the skin (B) 3 .4. 8 Postmortem analysis Histological grading scores of the repaired ... the injected cells were in defect site, para-patellar fat and injection site of the knee joint (figure 3.15 and 3.16) 71 Figure 3-15 MR imaging of the mini-pig's femoral condyle MR imaging...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 6
... confirming the report of Jing et al (2 06, 207) In addition, our results showed that we could detect labeled cells in vivo up to weeks, thus the SPIO labeling method of the cells can be a promising ... labeling concentration of MSCs can reduce the adverse effects of the iron particles Our results showed, after optimized labeling, that visualization of injected MSCs is indeed feasible in vivo Cells ... localization into different site of the inflammation was observed in the knee joint over time A majority of the cells moved to the surgery sites such as surgery scar, para-patellar fat and injection...
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Bone marrow derived mesenchymal stem cell (BM MSC) application in articular cartilage repair 7
... articular cartilage provides only a limited capacity of self -repair Cell based therapy is one promising approach in the treatment of damaged cartilage Bone marrow (BM) derived mesenchymal stem cell (MSC) ... Leukemia inhibitory factor Neurotrophin Chemokine (C-X-C motif) ligand 10 Colony stimulating factor (gran-macrophage) Colony stimulating factor (granulocyte) Integrin binding bone sialoprotein 97 ... transforming growth factor beta-3 (TGFβ3), bone morphogenetic protein (BMP4), vitronectin (VTN) Conclusion: As I showed in the previous chapter, injection of stem cells in the knee is a promising...
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Từ khóa: dissecting mesenchymal stem cell movement migration assays for tracing and deducing cell migrationhematopoietic stem cell development niches and signaling pathwayscell mesenchymal stem cell differentiation in vitromelanoma cell propagation cancer stem cell clonal evolution and interconversion models of tumorigenicityfunctional identification of neural stem cell derived oligodendrocytesdml and ddl variables as function parameters in rule conditionsestimated costs of dismantling removing or restoring items of property plant and equipment included as an increase in the value of the assets specifying the circumstances considered in the measurement processsupplement safety and toxicity of individual antiretroviral agents in pregnancyautologous growth factors and progenitor cells as effective components in bone grafting products for spinesusceptibility tumour behaviour and their potential as therapeutic targetsisolation culture and osteogenic chondrogenic differentiation of bone marrow derived mesenchymal stem cellsgeneration of functional islets from human umbilical cord and placenta derived mesenchymal stem cellsthe hematopoietic stem cell nichehome for friend and foestem cell biology and research impact factorstem cell biology and regenerative medicineBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXTăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)MÔN TRUYỀN THÔNG MARKETING TÍCH HỢPTÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ