hematopoietic stem cell development niches and signaling pathways
Báo cáo khoa học: A biophysical view of the interplay between mechanical forces and signaling pathways during transendothelial cell migration doc
... transmigration. Cell transmigration is also involved in processes suchas cancer cell metastasis and stem cell homing, and although the steps of cancer cell transmigration aresimilar to those for immune cells, ... mechanicalforces and signaling pathways during transendothelial cell migrationKimberly M. Stroka and Helim Aranda-EspinozaFischell Department of Bioengineering, University of Maryland, College ... stiffness on cell adhesion and migration. Many cell types, including ECs [52–55],smooth muscle cells [56–58], fibroblasts [23,54,59], neu-rons [60,61], stem cells [62], neutrophils [63,64], and macrophages...
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Báo cáo khoa học: Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways docx
... of cell proliferation, cell cycle, posi-tive regulation of mitosis, negative regulation of cell proliferation, and multicellular organism development) ,apoptosis (antiapoptosis, apoptosis, and ... tyrosine kinase signaling pathway, regulationof small GTPase-mediated signal transduction, G-pro-tein-coupled receptor protein signaling pathway, and signal transduction), cell growth (cell proliferation,positive ... Vegfaa Pathways targeted by upregulated miRNA.b Pathways targeted by downregulated miRNA. All of these pathways show increased enrich-ment, P-values, FDRs, and predicted targeted genes.Signaling...
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hematopoietic stem cell protocols
... hematopoietic stem cells. Science 241, 58–62.10. Uchida, N. and Weissman, I. L. (1992) Searching for hematopoietic stem cells:evidence that Thy-1.11o Lin- Sca-l+ cells are the only stem cells in ... functional properties and cell- cycle status of the samegroup of putative stem cells. Instead, cell- cycle analysis and assessment of hematopoietic potential of primitive progenitor cells have usually ... Lin– cellsG2 G2 = R1 and R2 Viable CD34+ Thy-1– Lin– cellsG3 G3 = R1 and R3 Viable CD34+ Thy-1+ Lin– cellsG4 G4 = R4 and R1 Viable Lin– cells in lymphoblastoid sizeG5 G5 = R1 and...
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... which a stem cell divides to generate one or two daughter stem cellswith developmental potentials that are indistinguish-able from that of the mother cell. This process is cen-tral to development, ... )embryonic stem (ES) cell lines and found that these mutant cells exhibited severedefects in cell proliferation without aberrant differentiation in vitro orin vivo. Furthermore, cell cycle analysis and ... ⁄ )ES cells. (A) AP staining of wild-type and Ptb) ⁄ )ES cells. The AP activities were positive in bothwild-type cells and the two Ptb) ⁄ )ES cell clones. Scale bar: 100 lm. (B) Cell proliferation...
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Báo cáo khoa học: Signaling pathways and preimplantation development of mammalian embryos potx
... Rac, and Rac caninduce JNK ⁄ MAPK signaling. Dkk1 and SOX7 are antagonists ofWnt signaling. Both are identified as direct targets of the p38 and JNK pathways. Y. Zhang et al. Signaling pathways ... late two -cell embryo [38]. Theonset of expression of Wnt4 is observed in the 4- ⁄ 8- cell stages, and is more strongly expressed at the8- and 16 -cell and blastocyst stages. Both Wnt3a and -4 ... oocytes and at later blastocyst stages; Notch4 and Dll-4 mRNAs can be detected from the two -cell stage to the hatched blastocyst stage; and Notch3, Dll-1 and Dtx1 mRNAs are found in two -cell embryos...
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Tài liệu Báo cáo khoa học: Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebrafish, Danio rerio docx
... shown that various unstimulated murine and human T-cells, B-cells, myeloid cells, monocytic cells and fibroblasts, but not neuronal cells or embryonic stem cells, express STAT6, indicating that ... effector cell populations exist,Th1, Th2 and Th17, characterized by their cytokinerepertoire and how they regulate B -cell and T -cell Keywordsadaptive immunity; fish immunology; T-cells;transcription ... ofantibodies by B-cells, and for the elimination ofextracellular pathogens, such as helminths and otherextracellular parasites [2]. Th17 is the most recentlyidentified Th cell subset and secretes...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... relevance. Theunderstanding of how cell swelling integrates into the cell cycle machinery and how cell shrinkage sensitizescells to apoptotic stimuli requires further scientificeffort. Cell hydration ... general, cell swelling stimulates ana-bolic metabolism and proliferation and provides cyto-protection, whereas cellular shrinkage leads tocatabolism and insulin resistance and sensitizes cells ... Anisoosmotically exposed cells and tissues were frequently used as a model in order tostudy osmosensing and osmosignaling. By thisapproach, the activation of signaling pathways by cell volume changes...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... the natureof the intracellular signaling pathways that link S1P signaling to Cyr61/CCN1 gene expression and showedthat the activation of RhoA GTPase and p38 MAPkinase pathways is required for ... ofthe signaling pathway coupling the actin cytoskeleton and Cyr61/CCN1 gene expression is required to better under-stand the interactions between actin dynamics and geneticprogramming in the cells.Within ... angiogenicfactor and a member of a family of growth factor-inducibleimmediate-early genes with functions in cell adhesion, pro-liferation and differentiation. We investigated the regulatorymechanisms and signaling...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... as hormone signaling, biotic and abiotic stress responses, and development [15,16], whereas high concentrations ofROS can result in oxidative stress and cause irrevers-ible damage and hypersensitive ... extracellular stimuli aretransmitted into the cell and are sensed by downstreamtargets via the sequential phosphorylation of a MAP-KKK, a MAPKK, and a MAPK [5]. The phosphory-lation and activation ... involved in various signaling processes and have unique biological functions.Cotton (Gossypium hirsutum) is one of the oldest and most important fiber and oil crops. Its growth and yield are severely...
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Trends in Cell Signaling Pathways in Neuronal Fate Decision Edited by Sabine Wislet-Gendebien potx
... and cerberus, thereby regulate the availability, and therefore, active signaling by their associated ligands [20]. TGF-β signaling is the archetype for signaling byTrends in Cell Signaling Pathways ... potential stem cell therapies is driven by new understand‐ings of stem cell biolology leading to specific cell fate decision.The main objective of this book is to offer a general understanding of signaling ... migration and differentiation of cells in the SVZ and the DGmay be influenced by the spatial and temporal expression profile of these TGF-β proteins after brain injury.Trends in Cell Signaling Pathways...
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Autoimmune Diseases – Contributing Factors, Specific Cases of Autoimmune Diseases, and Stem Cell and Other Therapies pdf
... cells, and CD8+ T cells synergistically destroy beta-cells, resulting in the onset of autoimmune Type 1 (DM). Both direct and indirect killing of beta-cells, mediated by CD8+cytotoxic T cells ... Autoimmune Diseases, and Stem Cell and Other Therapies 8 disease initiation method, with a single and defined myelin peptide allows for the observation and measurement of changing T cell specificities ... islet beta-cells in the pancreas (Toyoda and Formby 1998). Understanding insights of the mechanism of immune-mediated islet cell destruction and the interaction between the immune system and pancreatic...
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