Discovery of dengue virus host factors

Ngày tải lên: 09/09/2015, 11:16

... mimics of the fusion proteins of other retroviruses, and of orthomyxoviruses, paramyxoviruses, filoviruses, coronaviruses, and herpesviruses have also been identified and shown to inhibit viral ... Figure combination Inhibitory effect of peptides WN53 and DN59 alone and in Inhibitory effect of peptides WN53 and DN59 alone and in combination WN53 and DN59 peptides wer...

Ngày tải lên: 19/06/2014, 08:20

... 0–7 .3 0–6.7 17/7748 31 /10 132 33 /10728 47/14900 46/9 536 52/15496 2.2 3. 1 3. 1 3. 2 4.8 3. 4 3. 3 ± 0.8 4.1 3. 5 6.1 3. 6 6.8 6.5 5.1 ± 1.5 5/17005 16/24165 9/ 232 70 16/2 237 5 25/20585 8/16110 29/ 233 35 32 /30 515 ... ratio in domain III of viral isolates 3H was caused by the value of of dS at the denominator The positive selection on the domain III is not su...

Ngày tải lên: 19/06/2014, 08:20

... among various regions of full- length sequences of different genotypes of DENV-3 With the lack of full- length sequences of viruses belonging to old American genotype IV, only four DENV-3 genotypes, ... http://www.virologyj.com/content/5/1/63 Table 4: Comparison of sequence diversity (p-distance, %) of full- length genomic sequences among different genotyp...

Ngày tải lên: 20/06/2014, 01:20

... Ecuador00b I I I I I I I I I I I I I I I I I I I I I I (V)b I (V)b I (V)b II II II II II II II II II II II II II II II III III III III III III III III III III III III III III III III III III III III 1998 ... Asia/S.Pacific (I) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) India (III) In...

Ngày tải lên: 20/06/2014, 01:20

... outbreak in northern India in 2003 and its continued dominance again in 2004 indicates the resurgence of dengue- 3 in a dominant form The emergence of a newer dengue serotype after an interval ... III) The reemergence of highly fatal subtype III of DEN-3 in a dominant form, replacing the earlier circulating subtype IV of DEN-2 in India is a matter of great concern...

Ngày tải lên: 20/06/2014, 01:20

... mimics of the fusion proteins of other retroviruses, and of orthomyxoviruses, paramyxoviruses, filoviruses, coronaviruses, and herpesviruses have also been identified and shown to inhibit viral ... Figure combination Inhibitory effect of peptides WN53 and DN59 alone and in Inhibitory effect of peptides WN53 and DN59 alone and in combination WN53 and DN59 peptides wer...

Ngày tải lên: 20/06/2014, 04:20

... 0–7 .3 0–6.7 17/7748 31 /10 132 33 /10728 47/14900 46/9 536 52/15496 2.2 3. 1 3. 1 3. 2 4.8 3. 4 3. 3 ± 0.8 4.1 3. 5 6.1 3. 6 6.8 6.5 5.1 ± 1.5 5/17005 16/24165 9/ 232 70 16/2 237 5 25/20585 8/16110 29/ 233 35 32 /30 515 ... ratio in domain III of viral isolates 3H was caused by the value of of dS at the denominator The positive selection on the domain III is not su...

Ngày tải lên: 20/06/2014, 04:20

... found in DENV -3 genotype III of strains circulating in the South American region In order to map the amino acid substitutions found on the E protein structure of DENV -3 genotype III strains of the ... initial years of the introduction in the continent (1994-2000) and strains isolated in the Latin American region in recent years (see Figure 1) In this study,...

Ngày tải lên: 12/08/2014, 02:20

... as: Ang et al.: Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus Virology Journal 2010 7:24 Submit ... essential for mediating the infectious entry process of DENV into cells siRNA profiling of human membrane trafficking genes required...

Ngày tải lên: 12/08/2014, 04:21

... using the algorithm defined above, and the test statistic calculated This was repeated 1,000 times to estimate the distribution of the test statistic The distribution was estimated in 10 different ... different runs to check that it was stable Using the resulting distribution, the probability of observing the test statistic under the null hypothesis was estimated and d...

Ngày tải lên: 13/08/2014, 09:21

... developed an adeno-associated virus (AAV) system capable of expressing siRNA cassettes, and tested this vector with a siRNA cassette composed of a nucleotide sequence from the 3' NCR of the DEN ... for siRNA delivery and that this AAV system may be applied in clinical settings to attenuate DEN infection List of abbreviations AAV, adeno-associated virus; DCs, dendritic c...

Ngày tải lên: 14/08/2014, 19:22

... monocytes ….42 1.6 Molecular insights of neutralization and enhancement of DENV infection … 45 1.6.1 The role of FcγR DENV neutralization …………………………….… 45 1.6.2 The role of FcγR in ADE of dengue infection ... and enhancement of dengue infection would be important in the design of an effective dengue vaccine that protects against all four DENV ser...

Ngày tải lên: 08/09/2015, 22:14

... sensing for the detection of Dengue virus 72 iv Table of Contents 3.3.3 Binding affinity studies of the 2H2 antibody with Dengue and Dengue viruses 76 3.3.4 Effect of the membrane' s ... electrode CHIKV Chikungunya virus CPE Constant phase element DENV Dengue serotype virus DENV Dengue serotype virus DENV Dengue serotype virus DENV Dengue serotype virus D...

Ngày tải lên: 10/09/2015, 09:11

... ANTIGENIC DIVERSITY OF DENGUE VIRUS: IMPLICATIONS FOR VACCINE DESIGN MOHAMMAD ASIF KHAN (B Appl Sc (Hons.) and M.Sc., NUS) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY ...  175  8.1  Antigenic diversity and implications for vaccine design  176  8.2  Strategies for dengue vaccine development  . 181  8.3  Vaccine informatics and future vacc...

Ngày tải lên: 11/09/2015, 14:20