Homoeostatic regulation of cytokines to retard liver fibrosis 2
Homoeostatic regulation of cytokines to retard liver fibrosis 2
... 2 NOVEL REGULATORY ROLE OF HGF ON TGF-β1 ACTIVATION DURING LIVER FIBROSIS 2. 1 AIMS & OBJECTIVES Liver fibrosis is characterized by crucial changes to important cell types in the liver such ... of fibrous tissue, and disruption of the liver vasculature hindering liver repair High TGF-β1 also causes further apoptosis of hepatocytes, reducing the regeneration potentia...
Ngày tải lên: 09/09/2015, 10:07
Homoeostatic regulation of cytokines to retard liver fibrosis 1
... endothelia……… .12 1. 2 FIBROSIS ……………………………………………………………… .13 1. 2 .1 Etiology…………………………………………………………… 15 1. 2.2 Homeostatic Regulation Of Cytokines During Liver Repair/Wound Healing……………………………………………… .16 1. 2.2 .1 ... LIST OF TABLES………………………………………………………………xii LIST OF FIGURES…………………………………………………………….xiii INTRODUCTION 1. 1 LIVER STRUCTURE AND FUNCTION……………………………… .1 1 .1....
Ngày tải lên: 09/09/2015, 10:07
Homoeostatic regulation of cytokines to retard liver fibrosis 3
... 149.67 ± 247 .33 ± 167.75 ± AST (U/L) 46.67 ± 3. 67 1 23. 5 ± 182 ± 5. 93 14.85 LDH VALH 53. 5 ± 4.09 44 .33 ± 1 .33 VALD 19 .36 4.48 148 ± 1. 63 1 43 ± 8.96 291.5 ± 136 .75 ± 14. 43* ,# 131 .33 ± 82 (kU/L) ... particles demonstrated the ability to control the levels of fibrotic factors in vitro 3. 3 .3 Establishment Of DMN-Induced Liver Fibrosis 0In order to induce liv...
Ngày tải lên: 09/09/2015, 10:07
Homoeostatic regulation of cytokines to retard liver fibrosis 4
... and Chandel, N S (2006) Proc Natl Acad Sci U S A 103, 46 04- 4609 111 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 1 54 155 156 157 158 159 160 161 162 van't Veer, M B., ... 11 34- 1 144 Lim, Y S., and Kim, W R (2008) Clin Liver Dis 12, 733- 746 , vii Kisseleva, T., and Brenner, D A (2007) J Gastroenterol Hepatol 22 Suppl 1, S73-78 107 34 35 36 37 38 39 40 41...
Ngày tải lên: 09/09/2015, 10:07
Báo cáo khoa học: The specific delivery of proteins to human liver cells by engineered bio-nanocapsules doc
... inside (Fig 5B) Human hepatocyte specific delivery of EGFP by infection The preS1 peptide displayed on the surface of L particles recognizes the specific receptor present on human hepatocytes and is ... transmembrane region by replacing it with one of the transmembrane-type receptors to limit the topology of the particle to type I Our BNC has the same tis...
Ngày tải lên: 23/03/2014, 15:20
Regulation of cytokines by small RNAs during skin inflammation potx
... expression by small RNAs - possible roles of miRNAs in psoriasis An extensive and important group of non-coding RNAs (ncRNAs) appeared with the discovery of miRNAs More than 700 different miRNAs have ... Cite this article as: Bak and Mikkelsen, Regulation of cytokines by small RNAs during skin inflammation Journal of Biomedical Science 2010, 17:53 Page 19 of...
Ngày tải lên: 10/08/2014, 05:21
Zebrafish liver and pancreas development 1 roles of rbp4 in early liver formation 2 genetic ablation to deduce pancreas cell lineage
... gel 2 .1. 2 Recombinant DNA XI-XII XIII 6 10 11 11 12 13 14 15 16 17 17 18 19 20 21 22 23 25 27 28 28 28 29 29 29 II Table of contents 2 .1. 2 .1 Restriction endonuclease digestion of DNA 2 .1. 2. 2 DNA ... analysis of pancreas development 4.3.3 gcga promoter analysis 96 96 10 3 10 8 11 3 11 6 11 6 11 9 12 1 12 1 12 2 12 5 IV Table of...
Ngày tải lên: 12/09/2015, 08:16
Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
... deaminase, dTTP regulation occurs by binding of the inhibitor to an allosteric site in competition with the activator dCTP [7] For dCTP deaminase, the mechanism of dTTP regulation is not understood ... in a slow transformation from an inactive to an active enzyme dTTP inhibition may then be achieved by stabilizing the inactive form of pr...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... preponderant role of p38 in the regulation of gene expression at the level of mRNA stability The p38 MAP kinase is now known to stabilize a wide range of mRNAs including those encoding TNF-a, interferon ... organization of the actin cytoskeleton and the superinduction of the CTGF/ CCN2 gene Rho-like GTPases play a pivotal role in orchestrating changes...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... raise the possibility that GSK3 may help to coordinate increases in glucose uptake and glycogen synthesis allowing for more effective ÔchannellingÕ of glucose into glycogen in response to insulin ... Effects of insulin, Li and SB-415286 on signalling elements implicated in the regulation of GSK3 and GS To further understand the effects of Li and...
Ngày tải lên: 08/03/2014, 08:20
Báo cáo Y học: Regulation of RAS in human platelets Evidence that activation of RAS is not sufficient to lead to ERK1-2 phosphorylation pot
... Relocalization of RAS from the cytoplasmic to the cytoskeleton fraction could suggest an involvement of RAS during cytoskeleton rearrangement of platelets Our study shows that in platelets RAS is not sufficient ... activation of PKC, does not stimulate activation of ERK in platelets This result indicates that activation of RAS is not suffic...
Ngày tải lên: 08/03/2014, 16:20
Guide to U.S. Regulation of Genetically Modified Food and Agricultural Biotechnology Products
... characteristics of the genetically modified food to those of comparable food; • A discussion of “available data” on the allergenic and toxic potential of the modified food; • A description of any applications ... and its products could be the subject of regulatory review This report is intended to provide a general descriptive guide to the current set of...
Ngày tải lên: 13/03/2014, 21:59
Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... regulation is mediated by binding of the regulatory protein DmdR1 to the iron box located in the promoter region of the...
Ngày tải lên: 16/03/2014, 11:20
The natural history of non-alcoholic fatty liver disease in children: a follow-up study for up to 20 years pptx
... Laboratory evaluation included liver biochemistries (serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase activity, c-glutamyl transferase (GGT), total bilirubin, ... method The starting point for survival analysis was date of diagnosis of NAFLD Patient follow -up was extended up to April 200 8 The end-points for survival analysis...
Ngày tải lên: 22/03/2014, 10:20
SEC Finalizes Rules to Implement Dodd-Frank Act Regulation of Private Investment Funds and Their Managers ppt
... 4173) (111th Cong 2010) See our previous alert, SEC Proposes Rules to Implement Dodd-Frank Act Regulation of Private Investment Funds and Their Managers available at http://www.paulhastings.com/assets/publications/1774.pdf?wt.mc_ID=1774.pdf ... artzwickel@paulhastings.com Rules Implementing Amendments to the Investment Advisers Act of 1940,” Investment Adv...
Ngày tải lên: 23/03/2014, 12:21