F-ACTIN REGULATION OF SNARE-MEDIATED INSULIN SECRETION

... hypoglycaemic effect of ethyl acetate fraction with dose of 1000mg/kg is 36.75% (fig.2) compared to the mice before treatment (table 3). Moreover, stimulating effect of insulin secretion was proven. ... Especially, insulin secretion stimulating effect of the EtOAc fraction was 25.74%, higher as compared to other fractions. 3.4. Effect of ethyl acetate fraction on lipid...

Ngày tải lên: 12/02/2014, 17:20

... effects of alterations in insulin levels. Together, these new studies in Drosophila significantly broaden our understanding of the multiple layers of insulin- mediated growth regulation. Control of ... transcrip- tion of a number of target genes. Growth control by FOXO factors Could FOXO-regulated transcription play a role in growth regulation by the insulin/ PI 3-kinase p...

Ngày tải lên: 06/08/2014, 18:20

... representation of molecular mechanism involved in insulin signaling pathway that regulates glucose transporter (GLUT4) translocation to cell membrane. Some of the details like, other isoforms of insulin ... different values of dissociation constant [Kd 2 ] for binding of second molecule of insulin to phosphor- ylated insulin bound receptor. Simulated results indicate decr...

Ngày tải lên: 13/08/2014, 22:22

... Temporal profile of replication of human chromosomes. Proc Natl Acad Sci USA 102:6419–6424 Jiang W, Wells NJ, Hunter T (1999) Multistep regulation of DNA replication by Cdk phos- phorylation of HsCdc6. ... ini- tiation (Fig. 1). The chromatin loading of MCM2-7 depends on the loading of Cdt1 and Cdc6, which in turn depend on the loading of ORC. This step- Fig. 1 Regulation of...

Ngày tải lên: 25/10/2013, 21:20

... and Art. 11 of the Decree of the Council of Ministers of the USSR, 1 June 1990, ‘On Measures of Securing the Implementation of the Edict of the Presidium of the USSR Supreme Soviet of 26 November ... accompaniment of the CCGS John A. Navigation and pollution in the Northern Sea Route 229 40 See Arts. 6 and 10 of the NSR Regulations; Arts. 14 and 15 of the Economic Zone...

Ngày tải lên: 01/11/2013, 09:20

... that TPA- induced upregulation of miR-34a depends on the acti- vation of the ERK signal cascade and that miR-34a downregulates MEK1, which is one of the main regu- lators of ERK signaling, indicates ... expression of estrogen receptor-a (ERa) is autoregulated by miR-18a, -19b and -20b, which in turn are upregulated by the activation of ERa. This mechanism of regulation provide...

Ngày tải lên: 14/02/2014, 19:20

... direct dephosphorylation of Ser112 and negative regulation of the ERK pathway via p38 MAPK, both of which lead to impaired phosphorylation of Ser112 [70]. After dephosphorylation of Ser112, Ser136 becomes suscepti- ble ... the induction of DNA fragmentation, which is one of the most typical characteristics of apoptosis. Regulators of DNA fragmentation One of the terminal...

Ngày tải lên: 14/02/2014, 22:20

... translation of the PKM1 isoform, whereas inclusion of exon 10 produces PKM2 (REF. 71). MYC upregulates the expression of heteroge- neous nuclear ribonucleoproteins (hnRNPs) that bind to exon 9 of the ... Traxinger, R. R. Discovery of a metabolic pathway mediating glucose‑induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the inductio...

Ngày tải lên: 15/02/2014, 04:20

... Moreover, orientation of the CDE ⁄ CHR in the general context of a promoter appears to be rele- vant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent ... investigating downregulation of the cyclin B2 promoter is that after deletion or mutation of constitutively activating sites, such as the destruction of CCAAT-boxes,...

Ngày tải lên: 16/02/2014, 09:20