Báo cáo y học: " The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells" potx

... that p 21/ waf1 and cyclin D2 are complexed together in HTLV -1 infected cells. Cell cycle analysis of cyclin D2 and p 21/ waf1 p 21/ waf1 has been previously described as an assembly factor for cyclin ... cdk4, cyclin E, p 21/ waf1 wildtype (WT), p 21/ waf1 mutant in the cyclin binding site (mut), p16/INK4A, and cyclin D2 were expressed and purifie...

Ngày tải lên: 13/08/2014, 13:20

... phenylalanine was therefore mutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... value. k cat (s )1 ) K m (m M ) k cat /K m (m M )1 Æs )1 ) K iPAA (m M ) WT 16 .2 0. 015 10 80 0.05 bF24A 1. 6 0.275 6 1. 10 bF24L 36 0 .14 2 248 0 .15 bF24W 1....

Ngày tải lên: 17/03/2014, 23:20

... showed the induction of metalloproteinases by IL -17 in synoviocytes and chondrocytes [48–50]. Interestingly, the IL -17 family subtypes IL -17 F and IL -17 E also showed cartilage destructive potential in ... family members and their receptors Ligand Receptor Refs IL -17 (IL -17 A) IL -17 R (IL -17 AR) [5 ,11 ] IL -17 B IL -17 BR (IL -17 RH1/IL -17 ER) (low affinity) [7,8 ,18...

Ngày tải lên: 09/08/2014, 06:22

... The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002, 39:237-246. 11 . Goldring MB: Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther 20 01, 1: 817 -829. 12 . Brandt ... 378,930.3 10 3,236.2 IL-8 (n = 7) 325.62 10 8.67 211 . 81 64.35 245.04 75.69 13 4.75 37.48 MCP -1 (n = 7) 62.29 15 .43 60.29 16 .17 51. 58 13 .95 41. 56 11 .65 MMP -1 (n...

Ngày tải lên: 09/08/2014, 08:23

... to interfere with the inflammatory response in SLE by adminis- tering only an induction regime of four infusions of infliximab within 10 weeks rather than by planning for long-term therapy. Evidence ... 66:455. 60. Hayat SJ, Uppal SS: Therapeutic efficacy and safety profile of infliximab in active systemic lupus erythematosus. Mod Rheumatol 2007, 17 :17 4 -17 7. 61. Hayat SJ,...

Ngày tải lên: 09/08/2014, 10:22

... activation of proinflam- matory cytokines? In addition, it would be of interest to identify the type of cells exhibiting elevated PARP activity – for instance, perhaps by double staining with leukocyte markers. ... microscopy revealed evidence for type I pneumocyte membrane disrup- tion and endothelial detachment, indicating structural injury. In line with the findings by...

Ngày tải lên: 13/08/2014, 11:23

... which step (glycosylation or deglycosylation) of the hydrolysis of MUbglc by the mutant enzymes is rate-limiting, no hypo- thesis on the effect of R97 and Y3 31 on the rate constant of each step ... completely explain the DpK a of E187 in the Y3 31F mutant, because in the R97K and R97M mutants the same increment in the pK a of E399 did not change sig...

Ngày tải lên: 23/03/2014, 15:21

... was assessed by ascertaining the percentage of dam- aged leaves (ie leaves with yellowing) and the quantity of NaCl absorbed through the leaves shown by the increase of the Cl - ... aerosol The determination of surfactants and chlorides (the latter are useful as indicators of the pres- Original article The role of marine salt...

Ngày tải lên: 08/08/2014, 19:21

... health (including mental health) problems [8 -10 ]. Generally speaking the proximity to the event [11 -13 ], the severity of the incident [14 ], and the extent of the physical injury increases the risk of ... 59.7% Taking risks to find food 11 9 46.5% 12 5 44.2% Burning of houses 11 4 44.5% 11 7 41. 3% Witnessed events Arrests 13 6 53 .1% 13 7 48.4% Maltreatment...

Ngày tải lên: 13/08/2014, 13:21

... participates in the inhibition of papain and most likely also of cathepsin L. The side chains of Leu73 and Pro74 jointly contribute  45% of the total unitary free energy of binding of cystatin A to cathepsin ... for wild -type cystatin A. Enzyme Cystatin A form K d ( M ) k ass ( M )1 Æs )1 ) k diss (s )1 ) Papain Wild -type 1. 8 · 10 )13 a 3 .1 · 10 6a...

Ngày tải lên: 17/03/2014, 10:20