explain the role of art music and dance in african society

... result from the modifications in the interactions between the catalytic glutamates and the residues R97 and Y331, indicating that these residues play a role in the modulation of the Sfbgly50 pH optimum. Sequence ... m M Bicine buffer 7.0–8.5). The pH stability of Sfbgly50 was checked by incubation in the same buffers for a time equal to the assay time and then determining the activity remaining at the optimum ... [10,12]. Nevertheless, it is not possible to assume that the same is occurring in the mutant R97M, because there is no data on the interactions between the substrate and the arginine residue. Finally, another...

Ngày tải lên: 23/03/2014, 15:21

Ngày tải lên: 08/08/2014, 19:21

Ngày tải lên: 11/08/2014, 05:22

Ngày tải lên: 12/08/2014, 13:22

... only critical for the stability of the dimer, it may also be involved in maintaining the integrity of the active site. These results clearly suggest that the dimer interface in the Y74W* mutant ... bond with the backbone CO of F102. Fur- thermore, the orientation of the side chain of the two residues brings the guanidinium plane and the aro- matic ring of F102 into close proximity, with ... elevated temperature and in the presence of denaturants [27]. Extending these studies, we examine here the effect of increasing the bulk of the residue at position 74. Surprisingly, the Y74W mutant...

Ngày tải lên: 18/02/2014, 11:20

Ngày tải lên: 18/02/2014, 11:20

... by the amount of internalized agonist [20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin ... FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B 1 and B 2 bradykinin receptors Alexander Faussner 1 , Alexandra Bauer 1 , Irina Kalatskaya 1 , ... particular the part com- prising putative helix 8, may be involved in the inter- action of GPCRs with cognate G proteins. Synthetic peptides from the C-terminus of the G a subunit G t and of the Gc...

Ngày tải lên: 07/03/2014, 16:20

... of GSK3 (using Li or SB-415286) appears to be sufficient for inducing activation of GS in muscle and fat cells, and that inhibition of the kinase potentiates insulin action in muscle of insulin-resistant ... < 0.05. Results and discussion Effects of insulin, Li and SB-415286 on GSK3 activity As an initial starting point for our studies we investigated the effects of insulin, Li and the maleimide, ... phosphatidylinositol 3-kinase, p70, S6 kinase and glycogen synthase kinase-3 activity in L6 muscle cells: evidence for the involvement of the mammalian target of rapamycin (mTOR) pathway in the L -leucine-induced up-regulation...

Ngày tải lên: 08/03/2014, 08:20

... phenylalanine was therefore mutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of the enzyme ... PAA and derivatives thereof, while maintaining the hydrophobicity of the binding site. To test the effect of the mutations on the specificity for phenylacetylated substrates, the steady-state kinetic ... k cat represents the rate of acylation and K m equals the binding constant of the substrate to the free enzyme. The results then indicate Ó FEBS 2002 Role of active-site phenylalanines in penicillin acylase...

Ngày tải lên: 17/03/2014, 23:20

Ngày tải lên: 21/03/2014, 22:01

... founded in 1997 with the main objective of promoting research and educa- tion in the field of cultural heritage, based on the directions and recommendations given in the Professional Guidelines of the ... and of the paint layer, the characteristic “touche” of the author, the eventual existence of an underlying painting, the pentimenti, the alterations, the restorations, the modifications of frame, ... collaborate with the network. The main characteristics of these institutions, together with a database on the techniques used and the cultural areas in which they are working are mentioned in the website http://www.chim.unipg.it/chimgen/LabS...

Ngày tải lên: 22/03/2014, 09:20

... considered art music to be the happy middle point – die glückliche Mitte – in the strivings of man. 8 Art music as both an object and a means of solace thus held a key role in the cultural upbringing of ... analyses and disguise their value judgments as objective aesthetic opinions. V. aestheticI, aestheticII, aestheticIII, and . In the beginning of the 20 th century, in the course of this process, the ... start with the latter, during the last half of the eighteenth century taking part in cultural societies of different kinds became increasingly popular. A new literate and musically inclined bourgeoisie...

Ngày tải lên: 23/03/2014, 13:20

... unsure of the mechanism of DNA-induced stabilization of the protein, and whe- ther it is related to the normal RNA-binding function of coat protein, as RNA binding had no effect. The increased ... understood, and we have investigated these questions in this work. We sought to determine the role of protein–RNA and protein–protein interactions in virus stability, measuring the effects of urea, GdnHCl ... play a role in the different behavior. In the natural virion, a part of the maturase protein is present on the inner surface of the capsid shell where it interacts with viral RNA. Another part must...

Ngày tải lên: 30/03/2014, 11:20

... analyzing the determinants of venture capital investment in the United States between 1986 and 1998, they find that the likelihood of a ven- ture capitalist investing in a given target declines ... of industrial clustering. The organizations of the first economy, either because of their charter to do research as in the case of universities and R&D laboratories, or as a by- product of ... actual business outsourcing to India. The study accounts for the impact of cultural factors on knowledge transfer and on the likelihood to start a software firm, finding the software industry...

Ngày tải lên: 01/06/2014, 11:20

... people act in anticipation of their actions in the absence of ext ernally-a rising cues. The formation and maintenance of internal models has been studied in healthy individuals (reviewed in [17]), but ... important step in understanding the human-machine interface. By manipulating feedforward and feedback uncertainty we have shown that the seemingly trivial task of grasp- ing and lifting objects ... (left) and second (right) phases of training. Subjects performed significantly worse in the absence of either source of feedback. Saunders and Vijayakumar Journal of NeuroEngineering and Rehabilitation...

Ngày tải lên: 19/06/2014, 08:20

... BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP- 2 on fold increase in abundance of mineralization-related gene expression. Mineralizing ... visualized the mineralizing cells with 2% Alizarin Red. After rinsing in distilled water and air drying the samples, we mounted the cov- erslips on microscope slides using Fluoromount and examined and ... reduce the relative abundance of a majority of the mineralizing-associated genes.ThedramaticreductionofIGF-1byFGF-2sug- gests a role for IGF-1 in minera lization, this is i n agree- ment with findings...

Ngày tải lên: 20/06/2014, 04:20

... Li 4 Abstract Introduction: The difficulty in re-growing and mineralizing new bone after severe fracture can result in loss of ambulation or limb. Here we describe the sequential roles of FGF-2 in inducing ... visualized the mineralizing cells with 2% Alizarin Red. After rinsing in distilled water and air drying the samples, we mounted the cov- erslips on microscope slides using Fluoromount and examined and ... BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP- 2 on fold increase in abundance of mineralization-related gene expression. Mineralizing...

Ngày tải lên: 20/06/2014, 07:20

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