Báo cáo y học: "A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury" doc

... 5 Research A quality assessment of genetic association studies supporting susceptibility and outcome in acute lung injury Carlos Flores 1,2 , Maria del Mar Pino-Yanes 2 and Jesús Villar 1,3,4 1 CIBER ... (Continued) Positive genetic association studies with acute lung injury /acute respiratory distress syndrome susceptibility and/ or outcome (by y...

Ngày tải lên: 13/08/2014, 11:23

... this hypothesis in an acute lung injury animal model. Methods: Eight anesthetized piglets with collapse-prone lungs induced by lung lavage were ventilated with a fraction of inspired oxygen of ... assume that the ini- tial drop in PaO 2 seen in the present study was caused by a rapid collapse of lung regions induced by the removal of PEEP. Indeed, in pigs with lavage...

Ngày tải lên: 13/08/2014, 20:22

... variability. To increase inter- laboratory coherency, standardized methods and enzy- matic calibration should be used particularly for GGT and ALT assays. Expression of ALT and GGT in multiples of the upper ... prediction of the stage of liver fibrosis and grade of activity. Standardized methods and assay calibration should be used and expression of alanine aminotran...

Ngày tải lên: 13/08/2014, 13:20

... modifications of several proteins by deimination of arginine residues by peptidy- larginine deiminases [3,4]. The citrulline moiety is the true determinant in proteins recognized by antiperinuclear ... production, but also includes risk hierarchy for RA susceptibility and structural severity [35-37]. Trying to understand the findings of genetic association/ link- age studies...

Ngày tải lên: 09/08/2014, 10:20

... findings of associations between reproductive factors and the risk of developing RA in the NHS [56]. Data on pack-years of smoking (product of years of smoking and packs of cigarettes per day), ... can trigger inflammatory cytokines such as TNFα and IL-6, key cytokines responsible for the inflammatory response in RA [25]. Alternatively, androgens may influence RA risk in...

Ngày tải lên: 09/08/2014, 14:22

... power The intervention can increase appropriate medication use in two ways: by increasing use in those currently not on the medications of interest (i.e., increasing uptake), and by increasing the ... 1 Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA, 2 Division of Epidemiology and Community Health, University of Minnesota...

Ngày tải lên: 11/08/2014, 05:21

... [47,48] since, in the setting of painful OA, improved treatment of depression may reduce not only depressive symptoms, but also arthritis pain, activity limitations, and overall quality of life[16]. This ... cohort inclusion if they: i) reported difficulty in the last three months with each of the fol- lowing: stair climbing, rising from a chair, standing and walking; ii) sw...

Ngày tải lên: 11/08/2014, 15:22

... systemic inflammation and injury. Introduction Circulating leukocytes play a central role in host immu- nity, and are a major source of inflammatory mediators released in response to expo sure ... metabolic and malignant phenotype in cancer cells. J Biol Chem 2008, 283:22700-22708. 32. Lu CW, Lin SC, Chen KF, Lai YY, Tsai SJ: Induction of pyruvate dehydrogenase kinase-3 by hyp...

Ngày tải lên: 13/08/2014, 21:21

... eligibility, and study design (Figure 1). Of these articles, none fulfilled the criteria for high quality, 22 were of medium quality, and 11 were of low quality. Number of articles included in systematic ... triage, point -of- care testing (performing laboratory analysis in the emergency department), and nurse-requested x-ray. Thirty-three studies, including over 800,...

Ngày tải lên: 13/08/2014, 23:20

... RuMP cycle); (b) by conversion to formate via intermediates containing tetrahydromethanopterin (H 4 MPT); (c) via methylene-tetrahydrofolate (methylene- H 4 F) to the serine cycle and from there into biomass. ... roles of mcr homologs and of other genes potentially involved in reverse methanogenesis by directly assessing environmen- tal DNA and protein pools. Genomic insights into...

Ngày tải lên: 14/08/2014, 14:21