6 challenges of genetic association studies

... lung for 14 criteria (x-axis) used Percentage ofassessment of genetic association studies supporting for the quality assessment of genetic association studies supporting susceptibility and/or outcome ... Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease Nat Genet 2003, 33:177-182 Neale BM, Sham PC: The future of association studies: ... nearly absent as part of the statistical toolbox of the studies (89.7%) As few as studies (6.9%) supported the association in an independent validation sample [32,35] Only of 29 studies (20.7%) explored...

Ngày tải lên: 13/08/2014, 11:23

... groups (Table 4) In case of a combination effect of the three SNPs, we further analyzed the association of ATA haplotype with IL-10 production Table showed that the production of IL-10 was lowest ... the influence of interfering factors The patient cohort consisted of young patients with a low background of coexisting morbidity Similar to their association with IL-10 production, genetic variations ... clinical relevance of the IL-10 promoter polymorphisms in a larger cohort of trauma patients and to investigate the relation of these SNPs with other genetic polymorphisms in prediction of sepsis and...

Ngày tải lên: 13/08/2014, 20:21

... manifestations of allergy and asthma [15, 72] World-wide, high total serum levels of IgE have been used as a predictor of the development of asthma [15], thus gaining the understanding of the genetic ... leading to a release of a host of pro-inflammatory mediators, thus causing mucosal inflammation and the physical manifestation of the disease The role of IgE in the development of allergic disorders ... particular that of IgE, and thus, are mainly found in association with strong antibody and allergic response [23] The mode of which is via the production and secretion of an array of cytokines such...

Ngày tải lên: 30/09/2015, 14:23

... Source: Korean Textile Industry Association The most visible changes in Korean channels of distribution are the increasing market shares of discount stores, and the rise of Internet shopping These ... cannot make profits if they continue to increase sales commissions Taking into account sales commissions of 25%, intermediate management commissions of 15%, manufacturing costs of 30% and constant ... quality goods at reasonable prices Table 6: The Trend of Purchasing Place of Kids Apparel Source: Samsung DesignNet 19 Journal of Business Case Studies – November/December 2009 Volume 5, Number Focusing...

Ngày tải lên: 17/04/2013, 20:23

... low-frequency alleles Complementary functional studies should lead to a full understanding of the biological basis of the genetic associations of this region with autoimmune rheumatic diseases ... structure of the region This will be followed by well-powered genetic studies in both RA and SLE that will hopefully lead to the identification of the primary disease-related variants, some of which ... Approximately 20% of pseudogenes are transcribed, and some generate siRNAs that target homologous genes [8] Sequence variability in the sequence of the pseudogene could potentially affect expression of PTPN11,...

Ngày tải lên: 09/08/2014, 14:20

... Estimation of genetic OBERTSON closed herd of dairy cattle J Genetics, 50, 1-7 OBERTSON R A., 1977 The effect of selection Ziichtungsbiol., 94, 131-135 on gain in milk the estimation of yield by ... reciprocal of its standard deviation, U % gives the same economic value to an increase of one genetic standard deviation in fat as well as in protein content So the genetic correlation of U % was ... Heritability of milk yield and HMED HOMPSON at different levels and variability of production Anim Prod., 36, 59-68 W.G., composition INKOVSKI H T.S., 1968 Value of some genetic determinants of milk...

Ngày tải lên: 09/08/2014, 22:22

... CDKN2A/B [12] No association BCC, no association to CM KRT5, G138E substitution [12] No association BCC, no association to CM 7q32 adjacent to KLF14 [12] No association BCC, no association to CM ... precursors and markers of melanoma risk [33,34] The genetics of melanocytic nevus formation appear to be related to, but distinct from, CM development A meta-analysis of 46 different studies related ... predisposition to other such forms of cutaneous malignancies [12] Risk variants of cutaneous malignancies Association with pigmentation phenotype and risk of cutaneous melanoma A comprehensive...

Ngày tải lên: 11/08/2014, 12:20

... the period of mood disturbance Also recorded was the onset of first episode, the number of episodes, offset of last episode, and total duration of illness Psychiatric assessments of child family ... chr (hg17) Genomic Organization of RORB with Association Results Figure Genomic Organization of RORB with Association Results The genomic location and organization of RORB are shown, with exons ... disorder, it is possible they so by altering the expression of one or both of the RORB isoforms One of the haplotype blocks exhibiting a positive association (block in Figure and Table 2) spans the region...

Ngày tải lên: 11/08/2014, 17:20

... genome-wide association studies; RA, rheumatoid arthritis Competing interests This study was financially supported partly by the grant from the Ministry of Health, Labor and Welfare of Japan Author ... Gorlova OY, Amos C, Logothetis CJ: GWAS meets microarray: are the results of genome wide association studies and geneexpression profiling consistent? Prostate cancer as an example Plos One 2009, 4:e6551 ... http://arthritis-research.com/content/12/2/401 Page of Table Candidate genes identified from rheumatoid arthritis genome-wide association studies Gene GeneID PMID Gene expression (up or down)...

Ngày tải lên: 12/08/2014, 11:23

... A number of genes with association to allergic disease have been reported [12,13] The majority of studies are however for asthma phenotypes In 2006, Ober and Hoffjan presented a list of 118 genes ... gene-gene interaction studies in the molecular genetic analysis of asthma and atopy Clin Exp Allergy 1999, 29 (Suppl 4):47-51 Hoffjan S, Nicolae D, Ober C: Association studies for asthma and ... phenotypes probably share some of their genetic background However, only 17 of the genes listed in [13] were found to be associated with the rhinitis phenotype Very few of these studies have been replicated...

Ngày tải lên: 12/08/2014, 15:21

... examined in genetic association studies in infectious disease is IL-6 These studies have also produced conflicting results and highlight the problems with reproducibility in genetic association studies ... in part be responsible for the lack of reproducibility of many genetic association studies in sepsis A haplotype-based approach to candidate gene association studies enables us to avoid making ... strategies for genetic association studies, such as genome-wide association, practical, and they allow researchers to take an unbiased approach to association studies independent from selection of candidate...

Ngày tải lên: 13/08/2014, 11:23

... pathogenesis of AN has been emphasized in various studies [1-3] Accordingly, heritability estimates derived from twin studies revealed that 58–76% of the variance of AN can be explained by genetic ... lack of evidence for an association of the rs1049353 A-allele to patients with AN Contrary to our initial expectation of an effect size of 1.43 estimated from the trio sample, the true effect of ... receptor signalling as well as genetic variation of FAAH, NAAA and MGLL leading to increased enzyme activity might be implicated in the etiology of AN We performed association studies to analyse whether...

Ngày tải lên: 13/08/2014, 18:21

... survival was affected by FVL carrier status During a median of 698 (IQR: 24 to 1117) days of follow up, 23 of 28 (82.1%) carriers compared to 115 of 209 (55%) non-carriers died (log-rank test, P = 0.005, ... may influence the estimates of disease susceptibility because age is one of the most important risk factors for acquisition of infectious disease However, the effects of Factor V Leiden carrier ... approval of activated protein C (APC) for treatment of severe sepsis However, cohort G2 and, in part, the IPD cohort were established after 2002 In theory, use of APC could modulate the effect of the...

Ngày tải lên: 13/08/2014, 20:21

... methods for elucidating the genetic basis of CAD are presented Studies using association analysis to explain genetic basis of CAD are reviewed To obtain a better understanding of GWAS conducted in the ... search of genetic variants on a genome wide scale Therefore, association analysis provides a much more effective way to unveil the genetic basis of CAD 2.3 Genome wide association studies of coronary ... progress of GWAS of CAD as well as lipid traits and highlight the major findings 2.3.1 GWAS of CAD Genome wide association studies have identified multiple genetic variants associated with CAD Most of...

Ngày tải lên: 09/09/2015, 08:17

... DEPARTMENT OF EPIDEMIOLOGY AND PUBLIC HEALTH YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNVERISTIY OF SINGAPORE Association Analysis of Genetic Variation of Estrogen Related Candidate ... exposure: Genetic polymorphisms in ER cofactors 37 7.5.2.1 Molecular function of ER coactivator and ER corepressor 38 7.5.2.2 The constraints of ER cofactor study 43 7.5.2.3 Genetic association ... explore the association between genetic variants in ESR2 and breast cancer risk 7.5 Candidate gene based genetic association study Candidate genes are chosen in genetic association studies based...

Ngày tải lên: 09/09/2015, 17:58

... of before-and-after studies dealing with single-centre data [52-56] Inherent within this type of evidence is the lack of rigour and generalisability Furthermore, the magnitude of the effect of ... randomisation of hospitals requires large numbers of centres Before-and-after studies lack rigour and generalisability they are In the words of the slogan of the American Society of Critical Care ... Recordings of early signs of critical conditions were 7.7 times more frequent than late signs, with nurses accounting for 86.1% of these [45] Interestingly, in that study, 17.8% of all recordings of...

Ngày tải lên: 25/10/2012, 10:35

... control of end face geometry parameters The critical parameters include apex offset, radius of curvature and fiber height Endface Geometry’s Big Three Controlling each of the "big three" – radius of ... curvature of the ferrule endface measured immediately around the fiber core The apex offset is defined as the offset distance between the fiber core axis and the apex of the radius of curvature ... axis The peak, or apex, of this radius will generally be at the center of the surface being polished, and the distance between the center of the fiber and the center of the spherical surface...

Ngày tải lên: 22/10/2013, 18:15

... and disadvantages of each of the approaches just described and, if we're doing our job right, get a laugh or two out of the whole exercise A Perfect State Wasted, Dude! It's one of the things geeks ... value of the EXPIRES attribute Learning To Write The JSP Files (part 6): State Of Grace setDomain(someURL) − sets the DOMAIN attribute of the cookie getDomain() − returns the current value of the ... it − very similar to the behaviour of some of today's more adventurous teenagers, who get drunk every night, wake up the next morning with no memory at all of what happened, and go out again...

Ngày tải lên: 27/10/2013, 07:15

... occurs The result is that an apex offset of zero is possible However, if one wants to optimize the insertion loss of the connector via tuning, the orientation of this offset is not known until after ... difference between the center of dimension z (the center of the polished surface) and the center of dimension x1 (the center of the optical fiber) We can find z by using the law of sines: c= c=z C=2α ... the length of b) cosα Recognizing that apex offset is: z - x1 2cosθ , Where x1 = x0 + 2ytanα We insert z into apex offset: ApexOffset = cos α ( y+ Using the relation: 2cosx = ApexOffset = ( y+...

Ngày tải lên: 10/12/2013, 19:15

... examples of this kind of spin One of my favorites is a 1994 letter to shareholders from a major U.S software company: "A downsizing such as this one is always difficult for employees, but out of tough ... this field shows that anyone with normal intelligence is capable of doing some degree of creative work Creativity depends on a number of things: experience, including knowledge and technical skills; ... rewards today?" Quite often they'd say that the question isn't relevant that they don't think about pay on a day-to-day basis And the handful of people who were spending a lot of time wondering...

Ngày tải lên: 13/12/2013, 14:15