roles of lipid mediators in acute lung injury and pulmonary fibrosis

... above the lower inflection point was more effective in maintaining gas exchange and minimizing inflammation and lung injury than was PEEP set at the maximum curvature of the deflation pressure–volume ... opening and collapse lead to upregulation of an inflammatory response, with release of cytokines and chemokines and activation of neutrophils and macrophages that produce lung damage [2] Injurious ... demonstrated that RMs can increase oxygenation and lung volume in collapsed prone lungs However, the benefits of RMs in terms of oxygenation and lung recruitment in ARDS patients and in experimental models...

Ngày tải lên: 12/08/2014, 19:22

... Martin DP, Neff M, Stern EJ, Hudson LD: Incidence and outcomes of acute lung injury N Engl J Med 2005, 353:1685-1693 Bersten AD, Edibam C, Hunt T, Moran J: Incidence and mortality of acute lung injury ... deterioration in lung function The blood staining resolved following withdrawal of nebulised heparin Anticoagulant effects The mean APTT for each group following the final nebulisation, in order of increasing ... [19,20] In addition, in the setting of lung injury triggered by cardiac surgery, a preoperative heparin infusion reduced evidence of pulmonary microvascular thrombosis [21] We are unaware of previous...

Ngày tải lên: 13/08/2014, 11:22

... the pulmonary endothelium Production of IL-8 and other chemokines within the lung leads to recruitment of neutrophils and of other leukocytes into the interstitial and alveolar spaces of the lung ... studied the effect of fenoterol on the lung phospholipid metabolism in septic rats Fenoterol increased the incorporation of choline by 80% in normal lungs and by 35% in septic lungs Fenoterol restored ... studies of anti-inflammatory effects of beta agonists in acute lung injury Study Model Treatment Effect Perkins and colleagues, 2003 [54] Human neutrophils Salbutamol Inhibited chemotaxis Sekut and...

Ngày tải lên: 12/08/2014, 20:20

... Hawkins HK, Morita N, Murakami K, Mizutani A, Herndon DN, Traber DL: Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and ... showed the implication of ONOO- in the inactivation of a1-adrenoreceptors [28] and norepinephrine [29], and showed that superoxide deactivates catecholamines, resulting in loss of their vasopressor ... cells is critical in endothelial cell damage In our study there was no difference in NOx levels between the injured groups This finding stands in contrast to the findings of Isobe and colleagues,...

Ngày tải lên: 14/08/2014, 07:21

... embedded in paraffin wax, stained with hematoxylin and eosin, and examined under a light microscope The lung injury was scored according to inflammatory changes, hemorrhage of alveoli and interstitial ... (LTB4), interleukin-8 (IL-8), and LPS and compare the therapeutic effects of the combination of PDTC and wortmannin Materials and methods Induction of ALI New Zealand rabbits with a mixture of female ... Binding reactions were performed by adding μg of the nuclear extracts to a mixture containing 40 mol of biotin-labeled, double-stranded probes (5’AGTTGAGGGGACTTTCCCAGGC-3’) in 20 μl of binding...

Ngày tải lên: 18/06/2014, 19:20

... embedded in paraffin wax, stained with hematoxylin and eosin, and examined under a light microscope The lung injury was scored according to inflammatory changes, hemorrhage of alveoli and interstitial ... (LTB4), interleukin-8 (IL-8), and LPS and compare the therapeutic effects of the combination of PDTC and wortmannin Materials and methods Induction of ALI New Zealand rabbits with a mixture of female ... Binding reactions were performed by adding μg of the nuclear extracts to a mixture containing 40 mol of biotin-labeled, double-stranded probes (5’AGTTGAGGGGACTTTCCCAGGC-3’) in 20 μl of binding...

Ngày tải lên: 20/06/2014, 03:20

... The eosinophil infiltration of lung tissue using H&E staining was performed in an investigator-blinded fashion independently by an experienced pulmonary pathologist with a specialty in lung diseases ... evaluation of the H&E stained patient biopsies revealed little evidence of eosinophil infiltration in both control and ALI subjects (0.02 infiltrating eosinophils/ hpf and 0.04 infiltrating eosinophils/hpf, ... searching for gene candidates in acute lung injury Crit Care 2004, 8:440-447 38 Levitt JE, Gould MK, Ware LB, Matthay MA: The pathogenetic and prognostic value of biologic markers in acute lung injury...

Ngày tải lên: 12/08/2014, 14:20

... survival of patients with acute lung injury and higher number of circulating EPC than their counterparts with lower numbers [55] Also in pneumonia patients, circulating EPC increase Imaging data ... dissected and after clamping of the left pulmonary artery and vein with removable microvascular clips, the pulmonary vein was opened, flushed with heparinized saline solution, and the cuff was inserted ... sample With this internal standard it was possible to calculate the amount of circulating EC per ml of blood In vivo experimental protocol including the intravenous injection of EPC All experiments...

Ngày tải lên: 12/08/2014, 15:20

... shown to prevent lung injury and decrease mortality in rat models of ALI, suggesting a possible therapeutic use In rat models of bleomycin-induced and radiation-induced lung injury, pretreatment ... transport in the presence of acute lung injury In ALI, an inflammatory process damages the lung endothelium, resulting in high permeability of the lung capillaries to fluid, which leads to clinical pulmonary ... Verkman AS: Role of aquaporins in the alveolar fluid clearance in neonatal and adult lung, and in oedema formation following acute lung injury: studies in transgenic aquaporin null mice J Physiol...

Ngày tải lên: 12/08/2014, 20:20

... acute lung injury and the acute respiratory distress syndrome N Engl J Med 2000, 342:1301-1308 15 Anonymous: Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung ... Minelli C, Bertolini G, Brazzi L, Pimentel J, Lewandowski K, Bion J, Romand JA, Villar J, Thorsteinsson A, et al.: Epidemiology and outcome of acute lung injury in European intensive care unitsResults ... patients and physicians regarding withholding of prolonged ventilation and rehabilitation, bearing in mind the potential poor quality of life in the future that may result from such interventions...

Ngày tải lên: 13/08/2014, 03:21

... fibrinolysis in acute lung injury and acute respiratory distress syndrome Comparison of plasma levels of biomarkers of disordered coagulation and fibrinolysis in 50 patients with acute lung injury and acute ... is injurious in the acutely injured lung In a rat model of acid-induced lung injury, Frank and colleagues showed that lung endothelial and epithelial injury were minimized by a reduction in tidal ... The National Heart Lung and Blood Institute's ARDS Clinical Trials Network: Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury /acute respiratory...

Ngày tải lên: 13/08/2014, 08:21

... concentration and the tidal volume has been found in acute lung injury (ALI) patients, possibly reflecting ventilatorassociated lung injury [4] The EBC pH has been related to the extent of lung injury, and ... decrease proinflammatory cytokine expression, chemokine mRNA induction, and the resultant neutrophil lung infiltrate in an animal model of endotoxin-induced ALI [24] More recently, Perkins and colleagues ... salbutamol and acute lung injury: an association with improvement in acute lung injury Crit Care 2006, 10:R12 27 Morina P, Herrera M, Venegas J, mora D, Rodríguez M, Pino E: Effects of nebulized...

Ngày tải lên: 13/08/2014, 11:22

... Hernandez-Lopez J, Rodriguez-Gallego C: Mannose-binding lectin and mannose-binding lectinassociated serine protease in susceptibility, severity, and outcome of pneumonia in adults J Allergy Clin ... all-cause acute lung injury or acute respiratory distress syndrome ACE, angiotensin-converting enzyme; CXCL2, chemokine CXC motif ligand 2; F5, coagulation factor V; IL-6, interleukin-6; IL-10, interleukin-10; ... with acute lung injury /acute respiratory distress syndrome susceptibility and/ or outcome (by year of publication) aNames are those originally reported in the corresponding reference Ins/del, insertion-deletion...

Ngày tải lên: 13/08/2014, 11:23

... al lungs of sheep have a special feature, a single bronchial artery, and a single lymphatic draining of the lung A 10-fold increase in bronchial blood flow could be shown within 20 minutes of ... Hawkins HK, Morita N, Murakami K, Mizutani A, Herndon DN, Traber DL: Recombinant human activated protein C improves pulmonary function in ovine acute lung injury resulting from smoke inhalation and ... T, Neviere R, Fourrier F, Guery BP: Intravenous administration of activated protein C in Pseudomonas-induced lung injury: impact on lung fluid balance and the inflammatory response Respir Res 2006,...

Ngày tải lên: 13/08/2014, 11:23

... were similar in both ALI (n = 17) and ARDS (n = 13) patients Discussion The main findings of the study are that: moderate PEEP levels can lead to increases in IAP due to transmission of intrathoracic ... sedation and muscle paralysis and PEEP levels are needed Abbreviations ACS: abdominal compartment syndrome; ALI: acute lung injury; ARDS: acute respiratory distress syndrome; FiO2: fraction of inspired ... affects the value of intra-abdominal pressure in acute lung injury /acute respiratory distress syndrome patients: a pilot study Critical Care 2010 14:R137 Authors’ contributions DV and J-MC conducted...

Ngày tải lên: 13/08/2014, 21:21

... tract and proliferate, leading to focal inflammation of the lungs (4) In patients with severe pneumonia, infiltrating neutrophils produce pro-inflammatory cytokines and chemokines, resulting in ... courses of soluble endothelial selectin, C-reactive protein and lactate dehydrogenase after commencement of treatment for pneumonia, according to complicating acute lung injury The time courses of ... to inhibit the production of cytokines from lung epithelial cells not only by inhibiting elastolytic activity but also by modulating signaling cascades involved in the production of cytokines...

Ngày tải lên: 08/08/2014, 18:21

... 2003 Vol Matute-Bello and Martin Neutrophil apoptosis and acute lung injury Neutrophil apoptosis affects the pathogenesis or resolution of acute lung injury by three main mechanisms The first ... aerosolization of dead E coli That study suggests that in acute lung injury enhancement of neutrophil apoptosis is beneficial to the host Clearance of apoptotic neutrophils and acute lung injury The ... GM-CSF, and tumor necrosis factor-α) and increases release of anti-inflammatory mediators (i.e transforming growth factor-β1, prostaglandin E2, and platelet-activating factor) [1,18] These findings...

Ngày tải lên: 12/08/2014, 19:22

... diffuse lung edema due to inflammatory mediators originating in extrapulmonary foci [24] The increase in lung weight causes compression atelectasis of the dependent lung regions [27] Pulmonary ... SA: Clinical examination is an inaccurate predictor of intra-abdominal pressure World J Surg 2002, 26:1428-1431 Iberti TJ, Lieber CE, Benjamin E: Determination of intraabdominal pressure using ... function in humans Am Rev Respir Dis 1991, 143:25-31 Malbrain MLNG Intra-abdominal pressure in the intensive care unit: clinical tool or toy? In Yearbook of Intensive Care and Emergency Medicine Edited...

Ngày tải lên: 12/08/2014, 20:20

... factor) and plasminogen activator inhibitor type in patients with ALI [54–56] and ventilator-induced lung injury [57,58] Fibrinogen A and plasminogen activator, urokinase receptor are involved in ... of prekallikrein and direct release of bradykinin from kininogens Lab Invest 1996, 74:861-870 Fernando LP, Natesan S, Joseph K, Kaplan AP: High molecular weight kininogen and factor XII binding ... Candidate genes in acute lung injury Gene Ontology Encoded protein Gene symbol NR IM Interleukin-1β IL1B × × Interleukin-6 IL6 × Tissue factor precursor TF Plasminogen activator inhibitor-1 IN...

Ngày tải lên: 12/08/2014, 20:20

... better understanding of the extremely complex issues involved in improving the prognosis of this still life-threatening clinical problem More intriguing are the recent results showing that dead ... ventilation in ARDS patients Overdistension and the opening and closing of alveoli during tidal ventilation are important issues in ventilator-induced lung injury [9] Airspace collapse as shown by ... previous breaths and the applied PEEP level strongly determine the working envelope in the present breath and the chances of promoting intratidal recruitment during mechanical ventilation in ARDS patients...

Ngày tải lên: 12/08/2014, 22:22