Báo cáo khoa hoc:" Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment" doc

... of 5 (page number not for citation purposes) Journal of Negative Results in BioMedicine Open Access Brief report Role of metabolically active hormones in the insulin resistance associated with ... CA). Insulin sensitivity was assessed using the homeostatic model (HOMA-S), which is directly related to fasting insulin and glucose levels [13]. A weighted combin...

Ngày tải lên: 11/08/2014, 08:20

... also involved in fosfomycin binding, and in view of the multitude of interactions, it was assumed that deletion of a single interaction would not lead to a complete loss of fosfomycin binding. Therefore ... form of the protein. The results obtained with the K22V/R120K double mutant protein point toward a central role of arginine 120 in the conformational proces...

Ngày tải lên: 19/02/2014, 13:20

... by the C domain of the initiation module of dapto- mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Miao et al. [1]. In their work, the daptomycin ... group of Thr4 and the C-terminal Kyn13, resulting in a ten-membered ring [8]. More- over, several ORFs localized within the gene cluster are associated with the bio...

Ngày tải lên: 07/03/2014, 04:20

... used to describe the binding isotherms obtained previously for the b-casein 1–25 phos- phopeptide in this pH range, and the same model was adapted to fit the binding isotherm of OPN 1–149 mea- sured ... sequences found in SPs with known involvement in mineralization are shown in Table 1, and aligned sequences of their orthologues are given in Doc. S2 (see Supporting in...

Ngày tải lên: 29/03/2014, 23:20

... diabetes insipidus in a patient. On substitution of the arginine for serine instead of cysteine, binding capacity and function returned to wild-type levels indicating the importance of the cysteine ... sparse, leptin appears to be an important component of a feedback loop involving key metabolic regulators including insulin, glucocorticoids and the sympathetic nervous syste...

Ngày tải lên: 09/08/2014, 18:21

... concentration of the biotinylated Ig remaining on the cell surface was then quantified by measuring the binding of [ 125 I]Streptavidin. In the absence of bTSH, a very weak internalization of the TSHR ... were incubated at 4 °C with the Ig in the presence or in the absence of bTSH. After washing the unbound Ig, the cells were incubated for different period...

Ngày tải lên: 21/02/2014, 00:20

... states of the protein [49]. The thermal unfolding of the wild-type protein has been investigated using CD and fluorescence spectros- copy, and led to the observation that the unfolding transition of ... to the observed DDG value for the Cys-free mutant ()6.14 kcalÆmol )1 ). These results suggest that the increase in entropy of the unfolded state is a dominant factor...

Ngày tải lên: 16/03/2014, 06:20

... between vicinity of MMC to nerves and the severity of abdominal pain/discomfort symptom of IBS [3]. These findings, together with our current observation, suggest that the degranulation of MMC is ... test. Results The number of MMC in distal colon In the toluidine blue-stained colonic specimens, MMC was easily identified in the lamina propria. The mean number of...

Ngày tải lên: 07/08/2014, 18:20

... activated. Activation of Dvl induces the dissociation of GSK-3b from Axin and leads to the inhibition of GSK-3b. Next, the phosphorylation and degradation of b-catenin is inhibited as a result of the inactivation ... dissociation of GSK-3b from Axin and leads to the inhibition of GSK-3b. Next, the phosphorylation and degradation of b-catenin is inhibited as a resul...

Ngày tải lên: 10/08/2014, 22:21

... carbonyl of Asn by the nitrogen of the peptide group linking the Asn to the following residue [4–6] 2 . As hydrolysis of this intermediate may occur on either side of the imide nitrogen, the Asp ... discrepancies between the different unit cells in the crystal. Combining the crystal structure information with the results of this study, we conclude that the...

Ngày tải lên: 08/03/2014, 08:20