Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation pptx
Cyclic nucleotides and mitogen-activated protein kinases: regulation of simvastatin in platelet activation pptx
... phos-
phorylated by cyclic nucleotide-dependent protein kinase
in platelets, which plays important role in modulating
actin filament dynamics and integrin activation [13]. In
this study, simvastatin was found ... phosphoprotein (VASP)
and (D) phospholipase Cγ2 phosphorylation as well as (E and F) platelet aggregation in the presence of inhibitors of cyclic nucle...
Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... 400
[nM]
Fig. 5. Binding of n-Src and NR2A C-tail proteins. (A–F) Surface plasmon resonance showing binding of wild-type and mutant n-Src proteins
at concentrations of 0–400 n
M to NR2A C-tail protein immobilized ... studies of inactive and
active Src, the SH2 and SH3 domains are believed to
form a ‘regulatory apparatus’. Binding of the phos-
phorylated C-terminus to the S...
Báo cáo khoa học: Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide pot
... S-nitrosylation
of a protein( s) involved in the activation of ferritin
translation is the mechanism underlying our findings,
therefore further research is needed to delineate the
players involved in NO
+
-mediated, ... post-transcriptional
regulation of intracellular iron homeostasis. In iron-depleted conditions,
IRPs bind to IREs present in the 5¢-UTR of ferritin mRNA a...
Animal Waste and Water Quality: EPA Regulation of Concentrated Animal Feeding Operations (CAFOs) ppt
... housed in confinement,
and where the following conditions are met: (1) animals are confined or maintained for a total of 45 days or more in
any 12-month period, and (2) crops are not sustained in ... illustrates the variations and
complexity of state activities.
12
According to EPA, state regulation of AFOs and CAFOs often
involves both federal and state laws and...
Báo cáo khoa học: Tec family kinases: regulation of FceRI-mediated mast-cell activation ppt
... bound 2; IL, interleukin; Itk, IL-2-inducible
T-cell kinase; JNK, c-jun N-terminal kinase; LAT, linker for the activation of T cells; LT, leukotriene; MAPK, mitogen-activated protein kinase;
NFAT, ... chain enhancer of activated B cells; PDK1, 3-phosphoinositide-
dependent protein kinase 1; PH, pleckstrin homology; PK, protein kinase; PLC, phospholipase C; PtdIns3K, phosphatidyl...
Báo cáo khoa học: Death-associated protein kinase (DAPK) and signal transduction: fine-tuning of autophagy in Caenorhabditis elegans homeostasis doc
... between
autophagy and apoptosis, the role of death-associated
protein kinase (DAPK) in the regulation of autophagy
is particularly interesting. DAPK is a serine ⁄ threonine
kinase originally isolated ... age-dependent
damaged proteins and organelles and thus promote
lifespan extension.
Fig. 3. Schematic diagram of autophagy signaling pathway in
C. elegans. Autophagy induci...
Báo cáo khóa học: NF-jB- and c-Jun-dependent regulation of human cytomegalovirus immediate-early gene ppt
... exposure of macrophages to LPS and CpG-
ODNs also results in the activation of the mitogen-activated
protein kinase pathways, including the extracellular signal-
related kinase, c-Jun NH
2
-terminal ... kinase 6 and IjB kinase [30–34]. Sti-
mulation of this pathway by LPS and CpG-ODNs results
in the activation of IjB kinase [31,35]; subsequently, IjB
kinase phosphory...
báo cáo hóa học:" Gene and microRNA analysis of neutrophils from patients with polycythemia vera and essential thrombocytosis: down-regulation of micro RNA-1 and -133a" pot
... Response
Integrin Signaling
VEGF Signaling
Fcγ Receptor-mediated Phagocytosis in MPs
Neurotrophin/TRK Signaling
p53 Signaling
PTEN Signaling
IL-6 Signaling
PI3K/AKT Signaling
Erythropoietin Signaling
Clatrin-mediated ... that the increased
expression of CCR1 and CCL3 may contribute to the pro-
inflammatory profile of MPD neutrophils.
Changes in serum protein levels and neutrophi...
Báo cáo y học: "α Impact of VIP and cAMP on the regulation of TNF-α and IL-10 production: implications for rheumatoid arthritis" pps
... 13-
acetate/ionomycin displayed an augmented IL-10 response
upon addition of dibutyryl cAMP, with corresponding
downregulation in TNF-α, suggesting a complex interaction
between protein kinase C and protein kinase ... Arnalich F: Dif-
ferential effects of gastrin-releasing peptide, neuropeptide Y,
somatostatin and vasoactive intestinal peptide on interleukin-
1 beta, interleukin...
Báo cáo y học: "Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis" potx
... recognized in tissues and joints of
patients with RA. In particular, high levels of CCL18 were
measured in SF, and immunostaining of tissue sections
revealed CCL18 production in perivascular regions of ... CCL18 protein after 24 or 48 hours of
incubation (data not shown), indicating that TNF-α induced
CCL18 mRNA expression in the absence of protein synthesis.
Int...
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