Ophthalmic Drug Delivery Systems - part 7 docx

... PECL nanoparticles for carteolol. It was concluded that the drug entrapped in the oily core is more available for corneal absorption. 3 H-Labeled hydrocortisone- 1 7- butyrate-21-propionate ( 3 H-HBP) loaded ... including polymer -drug complex sys- tems, erodible microspheres, responsive particulates, in situ gelling systems, ion-exchange systems, and nanoparticles (15). B. Local Inject...

Ngày tải lên: 10/08/2014, 03:20

... of drugs in perspective vis-a-vis ocular drug delivery. First, the noncorneal penetration pathway involves the per- meation of drug across the conjunctiva and sclera and may contribute sig- nificantly ... tissue plasminogen-activator concentrations after subcon- junctival delivery, Ophthalmology, 100: 373 – 376 . 135. Pakes, S. P. (1998). V. A., Grant: Implantation of a sub-tenon drug...

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... effects on isolated non-pregnant myometrium and uterine arteries and their inhibition by deamino-ethyl-lysine-vasopressin and dea- mino-ethyl-oxytocin, Br. J. Obstet. Gynaecol., 90 :73 2. 5. Vilhardt, ... near future. We hope that novel drug delivery systems will be developed to deliver potent polypeptide drugs through the ocular route. REFERENCES 1. Lee, V. H. L. (19 87) . Ophthalmic...

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... octanol-water partition coefficients. J. Pharm. Sci. 67: 786 78 8, 1 978 . 16. M. M. Narurkar and A. K. Mitra. Prodrugs of 5-iodo-2 0 -deoxyuridine for enhanced ocular transport. Pharm. Res. 6:8 87 891, ... Brittam 96 Freeze-Drymg/Lyophilization of Pharmaceutical and Biological Prod- ucts, edited by Louis Rey and Joan C May 97. Percutaneous Absorption- Drugs-Cosmetics-Mechanism...

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... Ocularpharmacokineticsincludesthefeaturesofabsorption,distribu- tion,andexcretionfoundwithsystemicadministrationbutappliedtothe eye.However,owingtotheuniqueanatomyandphysiologyoftheeyeand surroundingtissue,ocularpharmacokineticsisconsiderablymoredifficult todescribeandpredictthanitssystemiccounterpart.Thetaskisfurther complicatedbythevariousformulations,routes,anddosingregimenstypi- callyencoun...

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... Rayborn, R. L., Munsen, E. S., and Levy, N. S. (1 976 ) Ketamine and IOP in children. Anesthesia Analgesia 55 :77 3 77 5. 61. Delamere, N. A., Coca-Prados, M., and Shelinder, A. (1993). Studies on regulation ... injection, increased as the drug diffusivity was reduced. Furthermore, the rate of drug elimination, which is inversely related to the drug s elimination half- life, decreased sig...

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... applied drugs in the rabbit. Pharm. Res. 15:1882–18 87, 1998. 50. Yen, W C., and Lee, V. H. L. Role of Na + in the asymmetric paracellular transport of 4-phenylazobenzyloxycarbonyl-L-Pro-L-Leu-Gly-L-Pro-D-Arg across ... Pz-Peptide Pz-peptide (4-phenylazobenzoxycarbonyl-Pro-Leu-Gly-Pro- D-Arg) is a hydrophilic collagenase-labile pentapeptide with a molecular weight of 77 7 daltons, which is c...

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... adenovirus encoding brain-derived neurotrophic factor (Ad- BDNF) coinjected with a free radical scavenger, N-tert-butyl-(2-sulfoph- enyl)-nitrone (S-PBN), resulted in the survival of 63% axotomized ... 39(15):2555–25 67. 71 . Peachey, N. S., and Chow, A. Y. (1999). Subretinal implantation of semicon- ductor-based photodiodes: progress and challenges. J. Rehabil. Res. Dev., 36(4): 371 – 376 ....

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... Transplantation, 64 :76 3 76 9. 87. E. Wagner (1999). Application of membrane-active peptides for nonviral gene delivery. Adv. Drug Deliv. Rev., 38: 279 –289. 88. M. X. Tang and F. C. Szoka. (19 97) . The influence ... colocalization of an angio- genin-inhibitor complex. Biochemistry, 37: 68 57 6863. 660 Das and Miller Copyright © 2003 Marcel Dekker, Inc. 73 . H. Moroson. (1 971 ). Polyca...

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