Insulin Action and Its Disturbances in Disease - part 1 ppsx
Insulin Action and Its Disturbances in Disease - part 1 ppsx
... 217 8 .16 Glucocorticoid metabolism and obesity 217 8 .17 11 β-hydroxysteroid dehydrogenase (11 β-HSD) 218 8 .18 Isoenzymes of 11 β-HSD 218 8 .19 11 β-HSD and obesity 219 8.20 Sex steroid metabolism and ... RECEPTOR AND DOWNSTREAM SIGNALLING L1′L2 L2′ insulin Fn Fn CR CR′ e1 e2 L1 Figure 1. 3 Insulin receptor ligand binding model (adapted from reference 15 ) 1 The Ins...
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Insulin Action and Its Disturbances in Disease - part 3 ppsx
... (PHAS -1 ) are in uenced by insulin. PHAS -1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS -1 and favours dissociation of eIF-4E and PHAS -1 . 14 This allows for binding ... sensitivity 22 FOXO1 transgenic Increased insulin sensitivity 62 PTP-1B −/− Enhanced insulin/ leptin sensitivity 26 SHIP2 −/− Increased insulin sensitivity/hypoglycemi...
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Insulin Action and Its Disturbances in Disease - part 4 ppsx
... frequency. 45 ICV injection of insulin reduces food intake and body weight in baboons and rodents 17 1, 17 2 and administration of anti -insulin antibodies into the rat hypothalamus increases food intake. 17 3 In ... Cellular mechanisms of insulin resistance. J Clin Invest 10 6, 17 1 17 6. 66. Zierath, J. R., Krook, A. and Wallberg-Henriksson, H. (2000) Insulin action...
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Insulin Action and Its Disturbances in Disease - part 3 pptx
... (PHAS -1 ) are in uenced by insulin. PHAS -1 binds to the eIF-4E cap binding protein, insulin enhances phosphorylation of PHAS -1 and favours dissociation of eIF-4E and PHAS -1 . 14 This allows for binding ... body protein synthesis in type I (insulin- dependent) diabetes patients by insulin- plus-glucose during amino acid infusion: studies of incorporation and turnover of...
Ngày tải lên: 09/08/2014, 15:20
Insulin Action and Its Disturbances in Disease - part 4 pdf
... acids and inhibits pancreatic insulin secretion. 10 11 β-HSD AND OBESITY 219 11 β-HSD2, a 405-amino-acid protein, is encoded for on chromosome 16 , and is localized to tissue expressing mineralocorticoid ... the renin–angiotensin system (RAS), plasminogen activator inhibitor -1 (PAI -1 ) and more recently omentin and visfatin. 79 TheroleofTNF-α, leptin, Il-6, resistin and a...
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Insulin Action and Its Disturbances in Disease - part 5 pptx
... resistin levels in obesity. 209 The resistin mRNA encodes a 11 4-amino-acid polypeptide containing a 20-amino-acid signal sequence. The secreted protein, resistin, is a 94-amino-acid disulfide-linked ... (2000) In vivo admin- istration of leptin activates signal transduction directly in insulin- sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology 14 1, 23...
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Insulin Action and Its Disturbances in Disease - part 6 pps
... insulin action via increased insulin receptor expression and increased activation of insulin receptor kinase. 91 11. 4 Summary Whole body insulin sensitivity is the product of a complex interaction ... adipose-derived protein Acrp30. J Clin Invest 10 8 (12 ), 18 75 18 81. THE IMPORTANCE OF BODY FATNESS 3 01 circulating free fatty acids have been linked to insulin resistanc...
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Insulin Action and Its Disturbances in Disease - part 8 pdf
... factors. PC -1 Plasma cell membrane glycoprotein -1 (PC -1 ) inhibits insulin receptor (IR) tyro- sine kinase activity and subsequent cellular signalling, possibly by inhibiting the IR by directly interacting ... potentially restoring cortisone into active cortisol, and 11 β-HSD-2 (mainly localized in the kidney), which inactivates cortisol unidirectionally. 209 The renal 11 β-HS...
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Insulin Action and Its Disturbances in Disease - part 9 pot
... within myocytes. This accumulation triggers PKC and IKK- β-mediated serine phosphorylation of IRS -1 , inhibiting insulin- induced tyrosine phosphorylation of IRS -1 and IRS -1 - associated PI3-kinase ... resistance. J Clin Invest 10 1, 11 11 11 20. 21. Dunaif, A., Green, G., Phelps, R. G., Lebwohl, M., Futterweit, W. and Lewy, L. (19 91) Acanthosis nigricans, insulin action,...
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Insulin Action and Its Disturbances in Disease - part 10 ppt
... Relationship to insulin resistance. J Clin Invest 97, 11 11 11 16. 15 9. Hotamisligil, G. S. et al. (19 96) IRS -1 - mediated inhibition of insulin receptor tyro- sine kinase activity in TNF- - and obesity-induced ... in the insulin- receptor gene. Diabetes 41, 14 73 14 90. 17 . Olefsky, J. M. (19 76) Decreased insulin binding to adipocytes and circulating monocytes from...
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