Handbook of clinical drug data - part 8 pptx

... activity of the product. From references 20 and 68 70. 80 7 ch10.qxd 8/ 13/2001 2:46 PM Page 80 7 Drug- Induced Hepatotoxicity This table includes only those drugs with well-established records of hepatotoxic- ity. ... Clin Res 1 982 ;30:659A. Abstract. 47. Coblyn JS et al. Gold-induced thrombocytopenia. A clinical and immunogenetic study of twenty-three pa- tients. Ann Intern Med...

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... information. 3 48 ch04.qxd 8/ 13/2001 1:46 PM Page 3 48 360 ␤-ADRENERGIC BLOCKING DRUGS COMPARISON CHART (continued ) β HALF- EXCRETED DOSAGE CARDIO- LIFE UNCHANGED PROTEIN LABELED STARTING MAXIMUM DRUG FORMS ... groups. 287 , 288 A substudy of the Helsinki Heart Study showed an increase in gallstone and gallbladder surgery in gemfibrozil-treated patients. After a 3.5-yr extension o...

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... nearly all isolates of Staphylococcus aureus and some isolates of coagulase-negative staphylococci are susceptible to these drugs. Methicillin- (actually ␤-lactam-) resistant staphylo- cocci have altered ... (start within 48 hr of onset of symptoms) 10 mg (2 inhalations) bid for 5 days. Give the first dose under the supervision of an informed healthcare professional to ob- serve co...

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... half-life of about 6 hr. IM or SC INTERFERON ALFA: ALFA-2A Pegasys, Roferon-A ALFA-2B Intron A, PEG-Intron ALFA-N3 Alferon N C YTOKINES 235 ch03.qxd 8/ 13/2001 1:33 PM Page 235 metabolite (␣-hydroxyflutamide) ... injection, 72% of the dose is recovered in the urine as ara-U, only 11 ± 8% as unchanged drug. 10 ,87 t ¹⁄₂ . (Conventional) ␣ phase 1.6–12 min; ␤ phase 2.6 ± 0.6 hr. 10 ,86...

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... metabolized via CYP3A4 to the 1-hydroxy- and 4-hydroxy-metabolites; the 1-hydroxy-metabolite is at least as active as midazo- lam. Midazolam’s half-life is 1 .8 6.4 hr. Adverse Reactions. Respiratory ... stability is unre- sponsive. 281 , 282 Loss of therapeutic effect is manifested by fluctuations in motor performance. Patients can experience periods of lack of drug effect (“off”...

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... containing Capsule con- Capsule con- Rectal suspen- coated pH mesalamine prodrug taining 5- taining ethyl- sion, sup- dependent cleaved by colonic ASA dia- cellulose- pository. (pH 7), de- bacterial azoreductases. ... Med Lett Drugs Ther 1 985 ; 27:97 8. 84 . Gralla RJ et al. Antiemetic therapy: a review of recent studies and a report of a random assignment trial com- paring metoclopr...

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... mean bioavailability of 64 ± 16% because of first-pass metabolism. 81 85 ,94 Norethin- drone acetate is rapidly converted to norethindrone in vivo. 81 ,85 ,87 ,90 Norethindrone is 36% bound to sex hormone-binding ... for methimazole. J Clin Endocrinol Metab 1 984 ; 58: 473–9. 207. Kampmann JP, Hansen JM. Clinical pharmacokinetics of antithyroid drugs. Clin Pharmacokinet 1 981 ;6:401...

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... of drug therapy, and, conversely, drug therapy can affect nutritional sta- tus. 19,36,37 ■ EVALUATING DRUG DATA FOR THE ELDERLY Because of age-related changes that may impact the outcome of drug ... ESRD. 34,35 As a conse- quence, the elimination half-life for both drugs is increased 6-fold in the presence of renal failure. This shows that predictions of the disposition o...

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... assessment, 1029–1030 ANTIALLERGICS, pregnancy, 89 7 ANTI-ANDROGENS, 245–246 ANTIARRHYTHMIC DRUGS, 297–321, 322–323 breastfeeding, 922–923 pregnancy, 88 7 ANTIASTHMATICS, 769–776, 777– 781 , 782 – 785 , 786 – 789 , 790 breastfeeding, ... units/L Adult 10–150 10–150 >60 yr 18 180 18 180 ␤-Lipoprotein (LDL) (S) 28 53% of total lipoproteins. 0. 28 0.53 Magnesium (S) mEq/L mmol/L 6–12 yr...

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