Handbook of clinical drug data - part 3 ppsx

ch03.qxd 8/13/2001 1:33 PM Page 219 A KLYLATING A GENTS 219 Adult Dosage PO 50–200 mg/m2/day for 10–25 days, repeated in 3–4 weeks Calculate the dosage based on IBW and reduce dosage for a BUN >40 mg/dL, Crs >2 mg/dL, or serum bilirubin >3 mg/dL Dosage Forms Cap 50 mg Pharmacokinetics The drug is rapidly and well absorbed after oral administration; CNS levels are equal to those in serum after 0.5–1.5 hr Procarbazine is 70% recovered in the urine, primarily as an acid metabolite, with