Handbook of clinical drug data - part 3 ppsx

... Purinethol THIOGUANINE A NTIMETABOLITES 231 ch 03. qxd 8/ 13/ 2001 1 :33 PM Page 231 Pharmacology. Alpha interferons are single-chain proteins. The alfa-2 interfer- ons are biosynthetic; alfa-2a has a lysine at position 23, alfa-2b an ... PEG-Intron ALFA-N3 Alferon N C YTOKINES 235 ch 03. qxd 8/ 13/ 2001 1 :33 PM Page 235 metabolite (␣-hydroxyflutamide) achieves levels of 0.720–1.68 m...

Ngày tải lên: 09/08/2014, 15:20

... Cap 133 .3 mg PO 3 caps bid. Not (See (See Generally well tolerated because and Ritonavir lopinavir plus established ritonavir.) ritonavir.) of lowered ritonavir dosage. Refrig- Kaletra 33 .3 mg ... nearly all isolates of Staphylococcus aureus and some isolates of coagulase-negative staphylococci are susceptible to these drugs. Methicillin- (actually ␤-lactam-) resistant staphylo-...

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... information. 34 8 ch04.qxd 8/ 13/ 2001 1:46 PM Page 34 8 36 0 ␤-ADRENERGIC BLOCKING DRUGS COMPARISON CHART (continued ) β HALF- EXCRETED DOSAGE CARDIO- LIFE UNCHANGED PROTEIN LABELED STARTING MAXIMUM DRUG ... questionable. 236 Levels of desace- tyldiltiazem are similar to those of diltiazem. 237 Fate. Oral bioavailability is 38 ± 11% with the first dose and 90 ± 21% with long- t...

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... as low as 7–12 mm Hg. 33 9 ,34 0 ,34 5 If the goal IOP cannot be reached, substitute a carbonic anhydrase inhibitor (CAI), latanoprost, or ␣ 2 -adren- ergic agonist. 33 9 ,34 0 ,34 6 If monotherapy is ... ocular cul-de-sac has a capacity of only about 7 ␮L. After instillation of an eye drop, this capacity temporarily increases to 30 ␮L. 34 1 34 3 Although manufacturers’ package insert...

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... containing Capsule con- Capsule con- Rectal suspen- coated pH mesalamine prodrug taining 5- taining ethyl- sion, sup- dependent cleaved by colonic ASA dia- cellulose- pository. (pH 7), de- bacterial azoreductases. ... Selectivity of 5-HT 3 receptor antagonists and anti-emetic mechanisms of action. Anticancer Drugs 1992 ;3: 79–85. 88. Holdsworth MT et al. Assessment of chemotherapy-...

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... metabolism of plasma lipoproteins. N Engl J Med 1991 ;32 5:1196–204. 132 . Lindsay R. Prevention and treatment of osteoporosis. Lancet 19 93; 341:801–5. 133 . Anon. Drugs for prevention and treatment of postmenopausal ... Aygestin F EMALE S EX H ORMONES 6 93 ch08.qxd 8/ 13/ 2001 2:24 PM Page 6 93 protein bound to albumin; 83% of a dose is present in serum as the parent drug and...

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... Z J Med 19 83; 13: 130 –4. 45. Gibbons RB. Complications of chrysotherapy. A review of recent studies. Arch Intern Med 1979; 139 :34 3–6. 46. Gottlieb NL et al. The course of severe gold-associated ... cough. J Int Med Res 19 83; 11:92–100. 72. Jacqz-Aigrain E et al. CYP2D 6- and CYP3A-dependent metabolism of dextromethorphan in humans. Phar- macogenetics 19 93; 3:197–204. 73. Woo...

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... 40–60 in 3 4 36 ,37 Cefmetazole HE 52–67 in 3 38 Ceftazidime CONV 2 40–50 in 4 22, 39 , 40 HE 58 in 3 SYN2 60–75 in 3 Cefepime HE 68 in 3 41, 42 SYN 1 72 in 3. 5 Cefprozil HE 55 in 3 43 Clavulanic ... of drug therapy, and, conversely, drug therapy can affect nutritional sta- tus. 19 ,36 ,37 ■ EVALUATING DRUG DATA FOR THE ELDERLY Because of age-related changes that...

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... Adult 3. 5–5.0 35 –50 >60 yr 3. 7–4.7 37 –47 Globulins Adult 2 .3 3. 5 23 35 Prealbumin Adult 10–40 mg/dL 100–400 mg/L Sodium (S,P) mEq/L mmol/L Child 138 –145 138 –145 Adult 136 –146 136 –146 Thyroid-Stimulating ... < ;3 62 10 785 FOR PEDIATRICS Aminosyn-PF 7% 1.82 3. 2 1.07 3. 4 — — — 33 — 586 Aminosyn-PF 10% 2. 63 4.61 1.52 3. 4 — — — 46 — 834 TrophAmine 6% 1.8 4.28 0. 93...

Ngày tải lên: 09/08/2014, 15:20