Báo cáo sinh học: "Drug-therapy networks and the prediction of novel drug targets" docx

... not previous drug targets [6]. In the analysis and visual representation of drug- therapy and drug- target networks, the weight of the links (such as the number of drugs binding to both of two linked ... predicting new drug targets, and to get around unwanted resistance and side effects of drugs. These tools promise to increase the number of novel drug...

Ngày tải lên: 06/08/2014, 18:21

... resources; and four, organizational resources. The structural aspects of EmOC and the inter- personal constituents of the EmOC process were easily identified. The clinical aspects of EmOC, where the ... AND "quality health care OR quality care" AND "developing countries". Based on the advice of one of the authors (PF), an expert in the fie...

Ngày tải lên: 18/06/2014, 17:20

... rates of evolution of synonymous sites [6] are affected by the need to specify ESEs. The issue of gene location gets to the heart of the relationship between genome organization and the control of ... measure of noise is variation in the expression level of the same gene in many otherwise identical cells. For some genes, there is a lot of variation, given the...

Ngày tải lên: 06/08/2014, 18:21

... it mathematically. One final example is the inheritance of the ABO blood groups, which was in doubt from the time of their discovery at the turn of the twentieth century until Bernstein’s mathematical ... simple algorithm for quantifying it. Similarly, the idea that the impact of mutation on the population depends on the mutation rate rather than the magnitude of...

Ngày tải lên: 06/08/2014, 18:21

... nucleosome positioning, and changes in the number of repeats affect the density and positioning of nucleosomes in the critical part of the promoter [52]. Expression divergence by cis and trans mutations In ... and others have proposed that because nucleo somes are thought to interfere with the binding of regulatory proteins, the regulation of nucleosome state...

Ngày tải lên: 06/08/2014, 19:21

... (-) strand synthesis. Fine-tuning of the efficiency of the strand-transfer processes may be modulated by many other features, including the local sequence and structure of the core body TRS and ... Inspection of the nucleotide composition along the genome indicates that the C-count increases significantly in the last one-third of the genome at the expense of...

Ngày tải lên: 18/06/2014, 22:20

... pharmacological and toxicological properties of the drug, but they often fail to grasp the complex effects of a drug on its target cells. In many cases, unexpected negative but also positive effects of a ... also gave new insights into the pathological mechanism of the disease. However, the mechanisms of action of anti-TNF agents are still not fully understood, an...

Ngày tải lên: 09/08/2014, 08:22

... are necessary and sufficient to mediate protein-protein inter- action. We then investigated whether the integrity of the coiled coil region of NP is important for the binding of NP to the polymerase cofactor ... for the homooligomerization of NP, formation of NP-induced intracellular inclusions, interac- tion of NP with VP35 and for the function of NP in RNA synt...

Ngày tải lên: 18/06/2014, 18:20

... en- ter of Sun Yat-Sen University. All the patients under- went radical surgery, and none of them had undergone either chemotherapy or radiotherapy before the collec- tion of the samples. The histopathologic ... Committee of our institution. Patients were informed of the investiga- tional nature of the study and provided their written informed consent. Follow-up o...

Ngày tải lên: 18/06/2014, 19:20

... participated in the analysis of the results and drafted the manuscript. AV participated in the analysis of the results and helped to draft the manu- script. AP designed the study, participated in the analysis of ... set [22,23]. The test for molecular clock and esti- mation of the time of split of these two viruses was done with TreePuzzle [21]. Competing...

Ngày tải lên: 19/06/2014, 08:20