Neurochemical Mechanisms in Disease P36 ppt

... neurotoxicity in an excitotoxic/pro-oxidant model of HD in rats (intrastriatal injection of quinolinate) (Maldonado et al., 2010) Calcineurin is a calcium-dependent serine/threonine phosphatase involved in ... and Windle, 2001). Proteins/polypeptides containing Q n domains in vitro form hydrogen bonds that link the glutaminyl side chains of the Q n domain to the peptide backbone in...

Ngày tải lên: 07/07/2014, 09:20

... people often had the same sorts of things going wrong with them, particularly during epidemics of what we now call infectious diseases. In fact, one of the books in the Hippocratic corpus is entitled “Epidemics.” 1.2.2 ... determined by experimentation; the properties of diseases are determined by consensus conferences. The names and classifications of diseases are inventions of the human...

Ngày tải lên: 07/07/2014, 09:20

... degradation. In adddition to the RING domain, c-IAP1 and c-IAP2 also contain a CARD domain located in the C-terminal region between the RING domain and BIR3. The function of CARD domains in these ... Most of the IAPs also contain a RING domain at the carboxy-terminus region which behaves as an E3 ubiquitin ligase. The RING domain adds ubiquitin residues to target proteins so they will b...

Ngày tải lên: 07/07/2014, 09:20

... motor neurons in the motor cortex and lower motor neurons in both the spinal cord and brain stem, first described by Charcot in 1869. Accompanying the cell loss are intra- cellular inclusions of ubiquitinated ... multifactorial disease a very challenging disorder for therapeutic intervention. 8 Dissecting Death Pathways in Vivo The increasing number of transgenic and knock-out murine...

Ngày tải lên: 07/07/2014, 09:20

... in the Parkin Gene (PARK2) The parkin gene, which maps to chromosome 6, encodes a 465 amino acid pro- tein containing an N-terminal ubiquitin-like domain, a central linker region, and C-terminal ... and a serine–threonine protein kinase domain. Most reported mutations were distributed throughout the serine–threonine protein kinase domain. Thus, loss of function of kinase activity of PINK1 i...

Ngày tải lên: 07/07/2014, 09:20

... Repeated cocaine use has been shown to increase DAT activity in humans (Mash et al., 2002). The ini- tial increase in extracellular dopamine after cocaine administration is thought to result in increased ... GABA B receptor agonist, has resulted in increased cocaine abstinence in cocaine-addicted patients (Shoptaw et al., 2003). Similarly, the GABA transporter inhibitor tiagabine th...

Ngày tải lên: 07/07/2014, 09:20

... pentylenetetrazole-kindling model of epilepsy in SAMP8 mice: glial-neuronal metabolic interactions. Neurochem Int 43:629–637 Kosenko E, Kaminsky Y, Grau E, Minana MD, Grisolia S, Felipo V (1995) Nitroarginine, an ... changes in patients and animal models of brain disease. However, although employing 13C-labeling and spectroscopy techniques may aid in mapping metabolic dysfunctions, the...

Ngày tải lên: 07/07/2014, 09:20

... plextrin homology (PH) domains, it contains an N-terminally located calponin homology (CH) domain, an SH3 domain, a GIT binding domain, and a C-terminally located leucine zipper that mediates the formation ... Lowe-syndrome patients, in addition to increased PI(4,5)P 2 levels, also had alterations in the actin cytoskeleton, an increased sensitivity to actin depolymerizing agents, and misl...

Ngày tải lên: 07/07/2014, 09:20

... increase in TH Ser40 phosphorylation at dopaminergic terminals t hat was associated with a commensurate increase in dopamine synthesis and turnover in striatum in vivo. Rolipram induced a small increase ... used in some clinical centers Cholinergic interneurons play an essential role in striatal mechanisms and increased acetylcholine release in the striatum is pathognomic for...

Ngày tải lên: 07/07/2014, 09:20

... the A n domains may (1) have a role in repression, (2) act as spacers or hinges, or (3) play important roles in correct protein–protein interactions and protein–DNA interactions during transcription. ... recruited into the deposits may be the wild-type A n -containing protein which may lead to a dominant-negative effect. In addition, expanded A n tracts may result in (a) decreased bin...

Ngày tải lên: 07/07/2014, 09:20