Neurochemical Mechanisms in Disease P18 doc

... part of an injury, infection, or autoimmune process, resulting in vaso- genic edema, which has a predilection for the white matter. Common mechanisms involved in cellular swelling include failure ... of sodium inside the cell, and increases in intracellular calcium, initiating an in am- matory response. Proteases and free radicals degrade extracellular matrix and tight junction prote...

Ngày tải lên: 07/07/2014, 09:20

... a long prodomain at the N-terminal region containing different protein–protein interaction motifs such as death effector domain (DED) found in caspase-8 and- 10 or caspase recruitment domain (CARD), ... the subsequent binding of TRAF2 (TNF receptor-associated factor 2) and RIP1 (receptor-interacting kinase-1), a DD-containing serine threonine kinase. When TRAF2 and RIP1 bind to the complex,...

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... mohamed.jaber@unv-poitiers.fr 49 J.P. Blass (ed.), Neurochemical Mechanisms in Disease, Advances in Neurobiology 1, DOI 10.1007/978-1-4419-7104-3_3, C  Springer Science+Business Media, LLC 2011 52 I. Ghorayeb ... caused by the mutations in PS-1 and PS-2. Presenilins are polytopic transmembrane proteins which are, in combination with three or other pro- teins (aph-1, pen-2, and...

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... Parkinson’s disease (preclinical and clinical stages). J Neurol 249(Suppl 3:III):1–5 Braak H, Ghebremedhin E, Rüb U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson’s disease- related ... zones in the human dentate gyrus during aging and Alzheimer’s disease. Brain Res 517(1–2):69–75 Birkmayer W, Hornykiewicz O (1961) Der L-3,4-dioxyphenalalanin (DOPA)- Effekt be...

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... and Traumatic Brain Injury 305 6.2 Role of NF-κB in Seizures 306 6.3 Role of NF-κB in Alzheimer Disease (AD) 306 6.4 Role of NF-κB in Parkinson’s Disease (PD) and Huntington’s Disease (HD) . ... Electroencephalogr Clin Neurophysiol 106:156–164 Hanninen T, Koivisto K, Reinikainen KJ, Helkala EL, Soininen H, Mykkänen L, Laakso M, Riekkinen PJ (1996) Prevalence of ageing-associate...

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... 2004). Investigation of the roles of NF-κB in brain diseases is just beginning, focusing mainly on acute and chronic neurodegeneration. Although the exact roles of NF-κB in these brain diseases ... myelin basic protein gene in oligodendroglioma cells (Huang et al., 2002). NF-κB in Brain Diseases 309 7NF-κB Signaling Pathway as a Potential Therapeutic Target The involvement of NF-κB i...

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... administration of the DA agonist apomorphine produces analgesia, and morphine induces an increase in the metabolism of DA in the SDH suggesting that the descending dopaminergic system is involved ... supraspinal opioid receptor mechanisms (Mahmoudi and Zarrindast, 2002). Furthermore, an increase in overall GABAergic activity in the insular cortex induces analgesia by enhancing the d...

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... at the origin of the disease. Nevertheless, we focus here on dys- and demyelinating diseases in which myelin modifications appear to be the primary events. This includes diseases involving the cells ... (2003) Painful in ammation- induced increase in mu-opioid receptor binding and G-protein coupling in primary afferent neurons. Mol Pharmacol 64:202–210 Zubrzycka M, Fichna J, Janecka A...

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... elucidated. Lysolecithin-induced demyelination. Injection of lysolecithin into the spinal cord causes a dramatic decrease in the levels of some myelin protein transcripts (MBP and PLP/DM20). Myelin protein gene ... a Biology of Demyelinating Diseases 551 result of peptidyl arginine–deiminase (PAD) activity converting arginyl residues to citrulline. The accompanying loss of positive charges...

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... cyclin-dependent kinase-5, p42/44 MAP kinase, p38 MAPK, stress-activated protein kinases, mitotic protein kinases) or a decrease in phosphatase activity (protein phosphatases 1, 2a, 2b), suggesting soluble ... 2009). Oxidative stress increases during aging, in parallel with the increased susceptibil- ity to several neurodegenerative diseases including AD. In AD, NFT accumulation within...

Ngày tải lên: 07/07/2014, 09:20