TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot

... TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER Edited by Rebecca L. Aft Targeted Apoptosis in Breast Cancer Immunotherapy 27 clinical breast adenocarcinomas (Vinothini ... Suitable Candidate for Breast Cancer Chemoprevention 157 Hsin-Ling Yang, K.J. Senthil Kumar and You-Cheng Hseu Targeting New Pathways and Cell Death i...

Ngày tải lên: 27/06/2014, 11:20

... Suitable Candidate for Breast Cancer Chemoprevention 157 Hsin-Ling Yang, K.J. Senthil Kumar and You-Cheng Hseu Targeting New Pathways and Cell Death in Breast Cancer 36 other potent cytotoxic ... 1471-4892 Targeting New Pathways and Cell Death in Breast Cancer 38 between proliferation and a hypoxia metagene in aromatase inhibitor tre...

Ngày tải lên: 23/03/2014, 17:20

... human and murine cancer cells, it is more damaging to human glioma brain cancer cells than to HL-60 leukemia cells (data not shown); b) Ruta induces cell division in normal human PBLs when grown in ... the arrest of cells in the G2/M phase, induction of endomitosis and fragmentation of DNA, leading to cell death; h) FACS analysis indicates that Ruta induces cell death...

Ngày tải lên: 22/03/2014, 17:20

... cancer cell lines Six NSCLC cell lines consisting of three adenocarci- noma cell lines (A549, H522 and H358), two large carci- noma cell lines (H460, H661), and one squamous cell carcinoma cell line ... participated in acquiring clinical and laboratory data, data analysis and interpretation, and drafted the manuscript. PP and LG participated in acquiring clinical...

Ngày tải lên: 18/06/2014, 16:20

... these pathways play in repressing BIM and in promoting aberrant cell survival in tumours that harbour mutations in oncogenes which control these pathways and (b) the role of BIM in tumour cell death arising ... imatinib therapy have point mutations in the BCR–ABL kinase domain, including the T315I gatekeeper mutation that impairs imatinib binding [58,59]. Accordingly...

Ngày tải lên: 16/03/2014, 00:20

... polyamine levels in the cell. Careful regulation of the transport of polyamines in and out of the cell also participates in keeping the polyamine pools a t an a ppropriate level f or the ongoing cellular ... caspase-dependent cell death in cultured human breast cancer cells induced by the polyamine analogue N 1 , N 11 -diethylnorspermine Cecilia Hegardt 1 , Oskar T. Johan...

Ngày tải lên: 17/03/2014, 23:20

... TNF-related apoptosis-inducing ligand [3]. Although caspases play a crucial role in cell death, increasing evidence suggests that cells can turn on caspase-independent modes of cell death under a variety ... AK, Ajay AK, Singh S & Bhat MK (2008) Cell cycle regulatory protein 5 (Cdk5) is a novel down- stream target of ERK1 ⁄ 2 in carboplatin induced death of breast cancer...

Ngày tải lên: 29/03/2014, 08:20

... adenine nucleotide translocase-2 by vector-based siRNA in human breast cancer cells induces apoptosis and inhibits tumor growth in vitro and in vivo. Breast Cancer Res 10, R11. 22 Shabalina IG, ... depletion induced no major changes in cell cycle and in mito- chondria aspect and network, and suggest that ADF cells possess alternative mechanisms for providing mito...

Ngày tải lên: 29/03/2014, 09:20