... site areinvolved in internalization and whether the rate con-stants of association and dissociation for [125I]TC-PCSK9 at 37 °C are similar to values obtained at4 °C. Our preliminary data indicate ... and neuronal differentiation. Proc Natl Acad SciUSA 100, 92 8–9 33.3 Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J,Chamberland A, Hamelin J, Tremblay M, Jacques H,Jin W, Davignon J et al. ... acid, indicating that the majority of bound [125I-TC-PCSK9 (and [125I]TC-PCSK9-D374Y)molecules remained intact and were still on the cell surface.Data analysisAll binding and kinetic data...