Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
Báo cáo hóa học: " Epidermal growth factor receptor gene copy number in 101 advanced colorectal cancer patients treated with chemotherapy plus cetuximab" doc
... reproduc-
tion in any medium, provided the original work is properly cited.
Research
Epidermal growth factor receptor gene copy
number in 101 advanced colorectal cancer patients
treated with chemotherapy ... an increase of Epidermal Growth factor
Receptor (EGFR) Gene Copy Number (GCN). Aim of this study was to assess the role of EGFR-GCN in a...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... EGFR
(including EGF, transforming growth factor- a, amphi-
regulin and epigen); (b) those that bind to EGFR and
ERBB4 (including betacellulin, heparin-binding EGF
and epiregulin); and (c) neuregulin ... Kinetic analysis of epidermal
growth factor receptor somatic mutant proteins shows
increased sensitivity to the epidermal growth factor
receptor tyrosine kinase inhibitor, e...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... gefitinib
for chemotherapy- naive patients with advanced non-
small-cell lung cancer with epidermal growth factor
receptor gene mutations. J Clin Oncol 24, 3340–3346.
15 Asahina H, Yamazaki K, Kinoshita ... to
therapy with mAb to epidermal growth
factor receptor in colorectal cancer
Cetuximab is a chimeric mouse–human mAb that tar-
gets the extracellular do...
Báo cáo khoa học: Epidermal growth factor receptor-regulated miR-125a-5p – a metastatic inhibitor of lung cancer potx
... lung samples were obtained from 15 patients treated at
the Zhejiang Province Cancer Hospital, with documented
informed consent being obtained in each case. Samples
were frozen in liquid nitrogen ... expression in a subset of
human lung cancers
To gain further insights into the role of miR-125a-5p
in lung carcinogenesis and to examine the clinical rele-
vance of our findings, we...
Báo cáo sinh học: " Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients" potx
... fibroblast growth factor; FGFR,
fibroblast growth factor receptor; PDGF, platelet-derived growth
factor; PDGFR, platelet-derived growth factor receptor; MMP, matrix-
metallo proteinase; uPa, urokinase-like ... a heterogeneous
group of tumors with poor prognosis. Fibroblast growth factor 2 (FGF2) and fibroblast growth factor receptor- 1
(FGFR-1), in close interplay...
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor pdf
... examples of latent
growth factors have already been reported. Insulin-like
growth factors are inactive when bound to insulin-like
growth factor- binding proteins. Transforming growth
factor- b is produced ... to induce renal injury in rats, HGF
in the kidney increased in quantity and was activated.
In contrast, HGF in the liver and spleen increased in
quantity but was no...
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): molecular structure and interactions with HGFA inhibitor-1 (HAI-1) doc
... predict, as in the case
of the related aprotinin–prostasin complex, in which
the 99-loop moves away from the substrate-binding
cleft to accommodate the Kunitz-type inhibitor aproti-
nin [15]. In some ... structure of HGFA (without inhibitor pres-
ent) reveals an active site in which key elements of the
substrate-binding site are changed in a way that is
incompatible with substrate...
Báo cáo khóa học: Nerve growth factor mediates activation of the Smad pathway in PC12 cells doc
... originating from receptor serine/threo-
nine kinases and receptor tyrosine kinases. Cellular
responses induced by bone morphogenetic protein
(BMP) for example, can be impaired by epidermal growth
factor ... signaling through receptor serine/
threonine kinases, nerve growth factor (NGF) signals via a
tyrosine kinase receptor (TrkA) which initiates multiple
pathways, the most...
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor ppt
... liver regenera-
tion in hPCI-Tg mice as compared with hPCI-Tg mice
treated with saline. The BrdU labeling index at 48 h in
the regenerated liver of the antibody -treated hPCI-Tg
mice increased ... with the serine protease hepatocyte growth factor
activator (HGFA), inhibiting the HGFA-catalyzed activation of the single-
chain hepatocyte growth factor precursor. In vivo s...
Báo cáo khoa học: Hepatocyte growth factor activator (HGFA): pathophysiological functionsin vivo potx
... contains multiple response
elements, including sequences binding SP-1, AP-2, Ets-
1, hepatocyte nuclear factor- 1, and nuclear factor- jB. It
also contains a hypoxia-inducible factor- 1a-binding ... were elevated in patients with
advanced prostate cancer [12,45], and the serum con-
centration of activated HGFA was elevated in patients
with multiple myeloma [13]. In breast...