epidermal growth factor receptor and ligands

... domain of epidermal growth factor receptor Cell 125, 1137–1149 Voldborg BR, Damstrup L, Spang-Thomsen M & Poulsen HS (1997) Epidermal growth factor receptor (EGFR) and EGFR mutations, function and ... result of heart and lung problems, while mice lacking other EGF ligands, or even triple null mice deficient for amphiregulin, EGF and transforming growth factor- a are viable [4] These ligands are synthesized ... Eleven ligands are known to bind to the ERBB family of receptors [3] These can be classified into three groups (a) ligands that specifically bind to EGFR (including EGF, transforming growth factor- a,...

Ngày tải lên: 16/02/2014, 09:20

... association with epidermal growth factor receptor/ transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti -epidermal growth factor receptor treatments ... transforming growth factor α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck Cancer 1996, 78:1284-1292 Baumann M, Krause M: Targeting the epidermal growth ... head and neck N Engl J Med 2006, 354:567-578 Cohen S, Carpenter G, King L Jr: Epidermal growth factorreceptor-protein kinase interactions: co-purification of receptor and epidermal growth factor- enhanced...

Ngày tải lên: 09/08/2014, 10:20

... RM, Baron AE, Zeng C, Franklin WA: Epidermal growth factor receptor in nonsmall-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J Clin Oncol ... Lindeman NI, Louis DN, Lee JC, Mark EJ, Longtine J, Verlander P, Kucherlapati R, Meyerson M, Haber DA, Johnson BE, Lynch TJ: Epidermal growth factor receptor mutation testing in the care of lung cancer ... 353(2):172-187 Janne PA, Engelman JA, Johnson BE: Epidermal growth factor receptor mutations in non-small-cell lung cancer: implications for treatment and tumor biology J Clin Oncol 2005, 23(14):3227-3234...

Ngày tải lên: 10/08/2014, 05:21

... confirmation and trials to understand their efficacy 1.2.3 ErbB4 ErbB4 shares some ligands with EGFR such as BTC, HBEGF and EPR, shares NRG1 and NRG with ErbB3 and has its specific ligands like NRG3 and ... transduction between the environment and the cells The signal transductions are initiated by the binding between growth factor receptors such as EGFR and ligands, and lipid rafts which appear to act ... polypeptide, now known as epidermal growth factor (EGF) (Cohen 1962) In 1975, the same group characterized its cell membrane receptor, namely epidermal growth factor receptor (EGFR) (Carpenter,...

Ngày tải lên: 10/09/2015, 09:25

... binding of ligand to EGFR induces receptor dimerization and consequent conformational changes that result in activation of the intrinsic tyrosine kinase, receptor autophosphorylation and a transient ... tumor specimens and establishment of cell lines from patients who have developed EGFR-TKI resistance is key References Mendelsohn J & Baselga J (2003) Status of epidermal growth factor receptor antagonists ... Messersmith WA, Hirsch FR, Franklin WA & Eckhardt SG (2009) KRAS mutations and sensitivity to epidermal growth factor receptor inhibitors in colorectal cancer: practical application of patient...

Ngày tải lên: 16/02/2014, 09:20

... (2002) Activation of BAD by therapeutic inhibition of epidermal growth factor receptor and transactivation by insulin-like growth factor receptor J Biol Chem 277, 27643–27650 10 Janmaat ML, Kruyt ... 2316–2326 11 Anderson NG, Ahmad T, Chan K, Dobson R & Bundred NJ (2001) ZD1839 (Iressa), a novel epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, potently inhibits the growth of ... phosphorylation of MKK4 and MKK7, and expression of MKP-1 and MKP-2 A, PC-9 cells were treated with 500 nM AG1478 for the indicated periods, and cellular lysates were analyzed by SDS ⁄ PAGE and immunoblotting...

Ngày tải lên: 18/02/2014, 13:20

... activation of the epidermal growth factor and nerve growth factor receptors J Biol Chem 271, 30505–30509 Browaeys-Poly E, Cailliau K & Vilain JP (1998) Fibroblast and epidermal growth factor receptor ... ATP, and epidermal growth factor in epithelial LLC-PK1 cells Am J Physiol 265, C966–C975 29 Elliget KA, Phelps PC & Smith MW (1996) Transforming growth factor b modulation of the epidermal growth ... Holcmann M (2007) The epidermal growth factor receptor: from development to tumorigenesis Differentiation 75, 770–787 18 Wieduwilt MJ & Moasser MM (2008) The epidermal growth factor receptor family:...

Ngày tải lên: 06/03/2014, 09:22

... cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor ⁄ extracellular signalregulated kinase ⁄ and EGF receptor ⁄ Akt pathway for proliferation Mol Cancer ... Aberrant epidermal growth factor receptor signaling and enhanced sensitivity to EGFR inhibitors in lung cancer Cancer Res 65, 226–235 Prenzel N, Fischer OM, Streit S, Hart S & Ullrich A (2001) The epidermal ... 1850–1855 5578 17 Ono M & Kuwano M (2006) Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs Clin Cancer Res 12, 7242–7251...

Ngày tải lên: 07/03/2014, 00:20

... 20538–20544 27 Ebner, R & Derynck, R (1991) Epidermal growth factor and transforming growth factor- alpha: differential intracellular routing and processing of ligand -receptor complexes Cell Regul 2, 599–612 ... Foundation and the Anders Jahre Foundation REFERENCES Schlessinger, J & Ullrich, A (1992) Growth factor signaling by receptor tyrosine kinases Neuron 9, 383–391 Komada, M & Kitamura, N (1995) Growth factor- induced ... serum-starved for h and then stimulated (b and d) or not (a and c) for with EGF Hrs was then immunoprecipitated and analyzed by 2D gel electrophoresis and immunoblotting with anti-Hrs Ig (a and b) or antiphosphotyrosine...

Ngày tải lên: 17/03/2014, 11:20

... systemically and evolutionarily guaranteed by the presence of a variety of ligands, or by dimerization and trans-activation with other family member receptors of ErbB [2,3] Additionally, the potency and ... patterns in constitutively active and gefitinib-sensitive EGFR mutants Oncogene 25, 1205–1215 Quian XL, Decker SJ & Greene MI (1992) p185c-neu and epidermal growth factor receptor associate into a structure ... EGFR regulators: SPRY4 (Sprouty-4) and ERRFI1 (MIG6) Sprouty family member proteins are known to be negative and positive regulators of fibroblast growth factor and EGFRs, respectively [10,21–23]...

Ngày tải lên: 30/03/2014, 01:20

... the epidermal growth factor receptor by immunohistochemestry J Clin Oncol 2005, 23(9):1803-1811 Moroni M, veronese S, Benvenuti S, et al.: Gene copy number for epidermal growth factor receptor and ... Biochemical and clinical implications of the ErbB/HER signaling network of growth factor receptors Adv Cancer Res 2000, 77:25-79 Diasio RB, Furie J: Targeting the epidermal growth factor receptor ... Oncology 2008, 9:402-403 Sartore-Bianchi A, Moroni M, Veronese S, et al.: Epidermal growth factor receptor gene copy number and clinical out come of metastatic colorectal cancer treated with panitumumab...

Ngày tải lên: 18/06/2014, 16:20

... M, Hughes JT: Epidermal Growth Factor Receptor expression in 72 meningiomas Cancer 1990, 66(1):152-155 Dorward NL, Hawkins RA, Whittle IR: Epidermal growth factor receptor activity and clinical ... Expression of epidermal growth factor receptors in human brain tumors Cancer Res 1984, 44:753-760 Westermark B, Magnusson A, Heldin CH: Effects of epidermal growth factor on membrane motility and cell ... and activation of epidermal growth factor receptors in meningiomas J Neurosurg 1997, 87(2):315-323 Diedrich U, Lucius J, Baron E, Behnke J, Pabst B, Zoll B: Distribution of epidermal growth factor...

Ngày tải lên: 09/08/2014, 09:20

... transforming growth factor- alpha and neuregulin-1 suppress active behaviors and cause weight loss in hamsters Brain Research 2005, 1038:171-182 Wakefield LM, Yang Y, Dukhanina O: Transforming growth factor- beta ... Danks JA, Chetty R, Burgess AW, Dunn AR: A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on the receptor biochemistry that results in impaired lactation ... variation resulting from a deficiency of epidermal growth factor receptor in mice is caused by extensive genetic heterogeneity that can be genetically and molecularly partitioned Genetics 2004,...

Ngày tải lên: 10/08/2014, 09:20

... Cognetti F, Maraninchi D, et al: Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic ... different end points and eligibility criteria; however, the understanding of trastuzumabrelated cardiac events has since improved, and the majority of these events are manageable and reversible Extending ... report and accompanying images A copy of the written consent is available for review from the Editor-in-Chief of this journal Abbreviations CT: computed tomography; HER2: human epidermal growth factor...

Ngày tải lên: 11/08/2014, 02:22

... , Nasuhara Y, Sato A, Takahashi T, Homma Y, Kawakami Y: Expression of epidermal growth factor and epidermal growth factor receptor immunoreactivity in the asthmatic human airway Am J Respir Crit ... of the epidermal growth factor receptor cascade The mechanism of EGFR expression and activation Stimulation of airway epithelial cells with TNF-α causes EGFR expression (the extracellular and intracellular ... MUC5AC production via expression and activation of epidermal growth factor receptor (EGFR) Am J Respir Crit Care Med 2001, in press 37 Verdugo P: Goblet cells secretion and mucogenesis Annu Rev Physiol...

Ngày tải lên: 12/08/2014, 18:20

... EGFR and EGFR ligands are expressed throughout the central nervous system and are involved in diverse developmental and homeostatic processes [8] SCN expression of EGFR [9-11] and transforming growth ... leukemia Blood 2005, 106:2827-2836 Gutacker C, Klock G, Diel P, Koch-Brandt C: Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells Biochem J 1999, ... Quantification of short term signaling by the epidermal growth factor receptor J Biol Chem 1999, 274:30169-30181 Terlau H, Seifert W: Influence of epidermal growth factor on long-term potentiation in the...

Ngày tải lên: 14/08/2014, 16:21

... inhibitor of epidermal growth factor signaling with potential for cancer therapy Cancer Res 2002, 62:5749-5764 Shin DM, Donato NJ, Perez-Soler R, et al.: Epidermal growth factor receptor- targeted ... sensitivity of human malignancies by epidermal growth factor Br J Cancer 1995, 72:615-619 Zhang M, Zhang X, Bai CX, Chen J, Wei MQ: Inhibition of epidermal growth factor receptor (EGFR) by RNA interference ... Jovin TM: Small interfering RNAs suppress the expression of endogenous and GFP-fused epidermal growth factor receptor (erbB1) and induce apoptosis in erbB1-overexpressing cells Exp Cell Res 2003,...

Ngày tải lên: 14/08/2014, 19:22

... (1993) A 40-kDa epidermal growth factor/ transforming growth factor a-binding domain produced by limited proteolysis of the extracellular domain of the epidermal growth factor receptor J Biol ... epidermal growth factor receptor J Biochem 127, 65–72 30 Abe, Y., Odaka, M., Inagaki, F., Lax, I., Schlessinger, J & Kohda, D (1998) Disulfide bond structure of human epidermal growth factor receptor ... position 13 of human growth factor in receptor binding J Biol Chem 268, 10114–10119 26 Campion, S.R & Niyogi, S.K (1994) Interaction of epidermal growth factor with its receptor Prog Nucleic...

Ngày tải lên: 24/03/2014, 03:21

... Roles of epidermal growth factor family in the regulation of postnatal somatic growth Endocr Rev 28, 284–296 Henson ES & Gibson SB (2006) Surviving cell death through epidermal growth factor (EGF) ... gift of the Bid vectors, and P S McPherson and P A Barker for useful discussion and advice We are also extremely grateful to Michel Bouvier and Billy Breton for guidance and assistance in our BRET ... Azakir BA & Angers A (2009) Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling Cell Signal 21, 1326–1336 Gao M, Labuda T, Xia Y, Gallagher E,...

Ngày tải lên: 16/02/2014, 09:20

... J., Cooper, J.A & Hunter, T (1984) C-kinase phosphorylates the epidermal growth factor receptor and reduces its epidermal growth factor- stimulated tyrosine protein kinase activity J Biol Chem ... Parker, P.J (1985) Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor Effect on tyrosine kinase activity and ligand binding affinity J Biol Chem 260, 14538– ... Buday, L & Downward, J (1993) Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor Cell 73, 611–620 12...

Ngày tải lên: 19/02/2014, 16:20