... in cancer cells,such as fibrosarcomas, breast cancer, mesotheliomasand prostate cancer, transfected with HAS1, HAS2and HAS3 genes, triggered intracellular signaling path-ways that promoted anchorage-independent ... expressedin breast, cervical and colon cancers, and in squamouscell carcinomas. Thus CD44v was chosen as a model for therapy. A Phase 1 clinical trial was performedwith an immunotoxin (humanized antibody ... high-light the relevance of CD44v isoforms in cancer whichseem to be suitable targets for anti -cancer therapy. Inseveral primary and cancer cells, CD44v6 forms a ter-nary complex with HGF and its receptor...