multifunctional nanoparticles for cancer therapy

... Chapter Multifunctional Nanoparticles for Cancer Therapy 59 Todd J Harris, Geoffrey von Maltzahn, and Sangeeta N Bhatia Chapter Neutron Capture Therapy of Cancer: Nanoparticles ... serve as multifunctional nanovector devices for cancer therapy, imaging, diagnostics, and monitoring of response to anti-tumor therapy Although the development of nanoplatforms for cancer therapeutics ... anti-tumor therapy Given the wide variety of nanovectors and nanoplatforms, Nanotechnology for Cancer Therapy cannot possibly cover each nanoscale application that has potential for use in anti-tumor therapy...

Ngày tải lên: 04/06/2014, 14:30

... in assessing tumor responses to therapy (i.e., estimating HER1 expression) and would provide accurate data for performing dosimetric calculations for radioimmunotherapy [36] The caveat to translating ... Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD 20892, USA Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, Center for Cancer ... candidates for targeted therapy due to their specificity, with their long residence time in the blood of days to weeks, they are not ideal carriers for imaging probes; it is extremely difficult to perform...

Ngày tải lên: 21/06/2014, 02:20

... SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLES FOR POTENTIAL CELL TARGETING, IMAGING, AND CANCER THERAPY APPLICATIONS HUANG CHAO (B.ENG., TIANJIN UNIVERSITY) A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR ... Superparamagnetic iron oxide nanoparticles (SPIONs) are very useful for biomedical applications, such as magnetic resonance imaging (MRI), hyperthermia for cancer therapy, cell targeting, drugs ... potential for various biomedical applications, including MRI for cell targeting and monitoring, drug/gene delivery, hyperthermia for cancer treatment, etc In addition, in contrast to other inorganic nanoparticles, ...

Ngày tải lên: 09/09/2015, 10:14

... (Zamecnik and Stephenson 1978; Crooke 1999) 1.6 Antisense Oligonucleotides for Gene-Related Disease Therapy Antisense for therapy is an active field of drug development (reviews in Agrawal 1996 ... oligonucleotides to the in vivo context differ somewhat for aptamers and for antisense Target accessibility is much less of a problem for aptamers than for antisense Many aptamer targets are extracellular ... subject of intense, sometimes excessive speculations for biomedical applications, often before B Tavitian Fig Oligonucleotides and biological information Table Oligonucleotides are modulators of...

Ngày tải lên: 29/06/2014, 11:20

... Introduction…………………………………………………………………… 41 2.2 Mie solution for spherical gold nanostructures…………………………… ……45 2.2.1 Mie coefficients for homogenous gold nanoparticles ………………… 45 2.2.2 Mie coefficients for core-shell gold nanoshells……………………………47 ... critical for early pre-cancerous detection and rational therapeutic intervention This thesis examines the use of gold nanostructures as an exogenous cancer- specific optical contrast agents for reflectance-based ... anionic species of the form [Au(OH)xCl4-x]¯ Whilst the pH is raised to by NaOH to form the dominant specie AuCl(OH)3¯ for DP process of seeding, the pH is raised to 10.1 by K2CO3 to form the dominant...

Ngày tải lên: 11/09/2015, 09:02

... Y, Maeda H: A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs Cancer Res 1986, 46:6387 Duncan ... Tokumitsu H, Ichikawa H, Fukumori Y: Chitosan-gadopentetic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by emulsion-droplet coalescence technique and characterization ... IC: Polymeric nanomedicine for cancer therapy Prog Polym Sci 2008, 33:113 Sheng Y, Liu CS, Yuan Y, Tao XY, Yang F, Shan XQ, Zhou HJ, Xu F: Longcirculating polymeric nanoparticles bearing a combinatorial...

Ngày tải lên: 20/06/2014, 22:20

... 55 chemotherapy for ovarian cancer Med Pediatr Oncol 1993; 21: 521-524 Baeksgaard L, Sorensen JB Acute tumor lysis syndrome in solid tumors-a case report and rewiew of the literature Cancer Chemother ... non-Hodgking lymphoma [15] Then PEG-uricase was proposed for cases of uncontrolled gout or for intolerance or not compliance to standard therapy [16] It was a mammalian, recombinant urate oxidase, ... Syndrome (TLS) Already before 2002, when Food and Drugs Administration (FDA) of US has approved the use of 85 urate oxidase for the management of paediatric patients at risk for TLS (Tumor Lysis...

Ngày tải lên: 31/10/2012, 14:59

... target for therapy Results from studies using several in vivo model systems support the notion that enzymatic activities responsible for syndecan-1 modification are valid targets for myeloma therapy ... functions in cancer Semin Cancer Biol 12, 173–186 12 Fuster MM & Esko JD (2005) The sweet and sour of cancer: glycans as novel therapeutic targets Nat Rev Cancer 5, 526–542 New concepts for heparanase ... for heparanase (upper) Nuclear heparanase is associated with decreased levels of phospho-EGFR, lower lymph vessel density, and favorable prognosis of head and neck cancer patients (see text for...

Ngày tải lên: 15/03/2014, 23:20

... transmitted in any form by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher For information on getting permission for reprints ... all the information, image by image, is a recipe for frustration (Figure 3a) Metadata presets are a way to apply several pieces of IPTC information to many photographs at one time For example, ... stands for Digital Negative Group and was designed by Adobe as a common raw format option for photographers It maintains all the quality and nondestructive editing benefits of proprietary raw file formats;...

Ngày tải lên: 30/05/2014, 23:16

... performance In this section, we will present a few methods for performing various tracking tasks that take advantage V.M Patel and R Chellappa, Sparse Representations and Compressive Sensing for ... Sensing for Vision Fig 4.2 Comparison between ARCS and a non-adaptive method for a dataset consisting of vehicles moving in and out of the field of view (a) Foreground sparsity estimates for each ... noise For both of the above examples we used SPGL1 [8] algorithm for solving the minimization problems In [23], [47], a theoretical bound on the number of samples that need to be measured for a...

Ngày tải lên: 05/06/2014, 12:05

... Background Prostate cancer is the most frequently diagnosed cancer and the second leading cause of cancer- related deaths for males in the USA One promising approach in prostate cancer diagnosis ... documented in small cell lung cancers [3], prostate cancers [4, 5], breast cancers [6-8] and others [9] In prostate cancer, the GRPR expression has been tied to neoplastic transformation [10], cell migration ... showed GRPR-dependant tumor uptake for both tracers Conclusion: Both 64Cu/NOTA-monomer and 64Cu/NOTA-dimer are suitable for detecting GRPR-positive prostate cancer in vivo by PET Tumor retention...

Ngày tải lên: 21/06/2014, 17:20

... staining for types I and III collagens, patchy staining for type II collagen, and a little for type VI collagen Most glycosaminoglycan staining was for chondroitin-4-sulfate, with less for keratan ... 3-B-3(–) and 7-D-4, which had no pretreatment Sections were fixed in 10% formalin before incubation with the primary antibody (before the enzyme digestion, in the case of the proteoglycan antibodies) ... 13.2 for these groups There was a correlation (r = 0.9, P < 0.001) between the two scoring systems for all the 26 cartilage samples Consistency of scoring between the three observers was higher for...

Ngày tải lên: 09/08/2014, 01:21

... and Metastatic Liver Cancer J Transl Med 2007, 14(5):15 Gulec SA, Mesoloras G, Stabin M: Dosimetric Techniques in Y-90 Microsphere Therapy of Liver Cancer: The MIRD Equations for Dose Calculations ... emerged as an effective liverdirected therapy with a favorable therapeutic ratio SIRT, both as a stand-alone therapy and in conjunction with systemic or regional chemotherapy (chemo-SIRT), has been ... continued systemic chemotherapy for a total of courses with no significant toxicity noted At 3month follow-up evaluation, based on a favorable tumor response, the patient's improved performance status,...

Ngày tải lên: 09/08/2014, 04:21

... 62°C for ADAMs 8, 9, 10, 12, 17, 20, 21, 28 and 30, 67°C for ADAM15, 64°C for VEGFR-1, 63°C for VEGFR-2 and neuropilin-1 and 65°C for β-actin, and minute at 72°C, followed by minutes at 72°C for ... manufacturer's protocols Cycling conditions were 50°C for minutes, 95°C for 10 minutes, and then 40 cycles at 95°C for 15 seconds and 60°C for minute Primers were designed and selected using Primer ... searches were performed to confirm the specificity of the probes Hybridization with the probes was performed at 42°C for 16 h, and the sections were washed in 2× standard saline citrate/50% formamide,...

Ngày tải lên: 09/08/2014, 07:20

... of radical RT for prostate cancer Acknowledgements This work was supported by grants from the Calgary Health Region Prostate Cancer Research Competition (2004) and the Alberta Cancer Board Research ... March 2010 Accepted: 10 June 2010 Published: 10 June 2010 undergoing conformal 3D external beam radiation therapy for prostate cancer based on an analysis of 10,327 pretreatment daily ultrasound ... Bosch W, Purdy J, Perez C: A critical evaluation of the planning target volume for 3-D conformal radiotherapy of prostate cancer Int J Radiat Oncol Biol Phys 1998, 42:213-221 Meijer G, de Klerk J,...

Ngày tải lên: 09/08/2014, 09:20

... colorectal liver metastasis in segment VII scheduled for high-dose-rate brachytherapy (HDR-BT) The implantation of one brachytherapy catheter was performed under MRI guidance (A) The tumor enclosing ... advanced cancer patients Hence, larger clinical studies have to confirm the ability of DWI to identify treatment response to anticancer therapy and identify the best time point to perform early ... that we performed an ANOVA with the adjusted F-Test by Greenhouse-Geisser to get a global test for time effects in each of the two groups Paired t test with Bonferroni correction for multiple...

Ngày tải lên: 09/08/2014, 09:20

... SBRT is considered a therapeutic option in stage I NSCLC either for inoperable patients or for patients refusing surgery SBRT for lung cancer is under evaluation in clinical trials Japan Clinical ... doublevacuum whole body immobilization system for stereotactic body radiation therapy Technol Cancer Res Treat 2004, 3:59-67 Stevens CW, Munden RF, Forster KM, Kelly JF, Liao Z, Starkschall G, ... volume in radiotherapy treatment planning for lung cancer? Radiother Oncol 1998, 48:71-77 Hof H, Herfarth KK, Münter M, Essig M, Wannenmacher M, Debus J: The use of the multislice CT for the determination...

Ngày tải lên: 09/08/2014, 09:22

... radiation therapy in head and neck cancers: An update Head Neck 2007, 29:387-400 Cerezo L, Pérez L, López M, Cruz A: Ipsilateral irradiation for oropharynx and oral cavity cancer: a proposal for case ... after the Figure Oral cavity cancer Oral cavity cancer Patient with a pT2N0M0 carcinoma of the left lateral border of tongue treated with postoperative radiation therapy for close margin and perivascularperineural ... radiotherapy in carcinoma of the tonsillar region Int J Radiat Oncol Biol Phys 2001, 51:332-43 Jensen K, Overgaard M, Grau C: Morbidity after ipsilateral radiotherapy for oropharyngeal cancer...

Ngày tải lên: 09/08/2014, 10:20

... craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study J Clin Oncol 1999, 17:2127-2136 Mehta M, Bradley K: Radiation therapy for leptomingeal cancer Cancer Treat Res ... in its current formulation does not directly incorporate the effects of chemotherapy, which has emerged as a central component of therapy for patients with medulloblastoma Chemotherapy may improve ... behind to minimize morbidity Alternatively, chemotherapy can reduce the tumor burden when administred before and/or with radiotherapy In addition, chemotherapy may substantially increase radiosensitivity...

Ngày tải lên: 09/08/2014, 10:21