an important target in cancer therapy
Báo cáo y học: "Gene Therapy: The Potential Applicability of Gene Transfer Technology to the Human Germline"
... contain no transgene sequences, another in would contain transgene sequences in 100% of their cells, and the remaining from individuals would be mosaics, consisting of 1/3rd or 2/3rd transgene-containing ... founder animals integrating and expressing the transgene [51, 52] Transgene uptake and expression following transgenICSI has also been reported in rhesus monkey embryos [53, 54] and porcine embryos ... telomeres and replication origins, and are maintained autonomously within the host cell Structural genes, promoters and enhancers (etc) can be included in MACs Preliminary research indicates...
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Tài liệu The Influence of Human Activity on the Environment ppt
... Improvements in agriculture health and medicine have produced a dramatic rise in the human population This increase in population size leads to an increase in pollution and higher demand for the ... while other plants are killed Sulphur dioxide will dissolve in rain producing Acid Rain • Acid rain damages trees and pollutes rivers and lakes Acid rain causes erosion of buildings and statues ... and plant habitats are destroyed causing extinction of species Intensive Farming • Farming has become more intensive to provide a higher % yield from land • Many people regard intensive farming...
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Tài liệu Deteriorating Access to Women’s Health Services in Texas: Potential Effects of the Women’s Health Program Affiliate Rule doc
... such as breast and cervical cancer screening, diabetes and hypertension screening, and testing for HIV and sexually transmitted infections For many women, particularly younger low-income women, ... practitioners and physician assistants These shortages mean that Texans, particularly lowincome or uninsured Texans, can have serious problems finding a health care provider to provide care and facilities ... planning services in Texas beginning in 2011.46 It was important to ask respondents about how this affected them, since this has already dramatically affected the market for family planning in...
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Tài liệu Male Reproductive Health Disorders and the Potential Role of Exposure to Environmental Chemicals pdf
... Cuninkova M, Møller H 2006b Trends in testicular cancer incidence and mortality in 22 European countries: continuing increases in incidence and declines in mortality Int J Cancer 118: 3099-3111 Brouwers ... diagnosis From: Cancer Research UK, http://info.cancerresearchuk.org/cancerstats/types/testis/incidence/ Graph to show increase in incidence of testicular cancer from 1975-2005 in Britain Rate per ... Spain Lithuania Rate per 100,000 males 10 12 From: Cancer Research UK, http://info.cancerresearchuk.org/cancerstats/types/testis/incidence/ Bar chart to show differing incidence of testicular cancer...
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Tài liệu Evaluation of physical activity programmes for elderly people - a descriptive study using the EFQM’ criteria ppt
... participated in the coordination of the study and supervised the drafting and editing of manuscript JC participated in the design of the questionnaires/interviews and coordination and management ... collection and analysis and supervised the drafting and editing of manuscript PS designed the study protocol and helped design the questionnaires/interviews RS managed the data collection and analysis ... the ACSM position’s stand [6] and ACSM’s Guidelines [83] In our study we found an unanimous result concerning the components of the exercise training session, which is in line with the ACSM recommendations...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
... Pantothenate kinase is an essential regulatory enzyme in co-enzyme A biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine and pantetheine [20] PANK2 ... extremities Both involuntary movements and rigidity may involve muscles supplied by cranial nerves, resulting in difficulties in articulation and swallowing Mental deterioration and epilepsy occur in some ... participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– 10185 Vanier MT...
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Tài liệu An Empirical Analysis of Political Activity in Hollywood pptx
... Arquette Rosanna Arquette Sean Astin Rowan Atkinson Charlotte Ayanna Dan Aykroyd Hank Azaria Kevin Bacon Simon Baker Alec Baldwin William Baldwin Christian Bale Fairuza Balk Eric Bana Antonio Banderas ... Almodovar Robert Altman Anthony Anderson Gillian Anderson Paul Anderson Paul Thomas Anderson Wes Anderson Jennifer Aniston Penelope Ann Miller Shiri Appleby Christina Applegate Alan Arkin Darren Aronofsky ... from Hollywood have been1 important, and remain important today, in modern American politics Movie stars and directors rank among the wealthiest individuals in the country, and their money is highly...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... exhibiting insignicant sequence identity with P450s in the heme-binding region [282], but bearing a C-terminal avoprotein fragment in the single polypeptide chain structurally resembling NADPH-P450 ... reduction and oxidation of myoglobin and hemoglobin by nicotinamide adenine dinucleotides and avins J Biol Chem 244, 67026706 151 Adams, P.A & Berman, M.C (1982) Hemin-mediated para hydroxylation of aniline: ... implicating the involvement of a peroxo adduct in catalysis [243] In fact, reactivity was enhanced when H2O2 was the oxidant in place of reductant and air [243], and the putative Fe(III)-OO(H) intermediate...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... of peroxidases in vivo An example is the killing of microorganisms in pathogen-defence mechanisms of neutrophils and other phagocytic white blood cells The dominating protein in neutrophils is ... and secondly the possibility to act as a tool for rapid adaptation to changing conditions by inducing immediate changes between two reaction pathways, without requiring any involvement of changes ... experiments showing nonoscillatory behaviour using different infusion rates of NADH and different stirring rates, corresponding to different oxygen transfer constants, to compare the rates of inactivation...
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Tài liệu AMAZONIAN ACCESSIONS OF WILD HEVEA GERMPLASM - A POTENTIAL SOURCE OF DROUGHT TOLERANCE pptx
... chlorophyll fluorescence parameters and percentage inhibitions in top ranking clones Sl.No Accession % inhibition in Fv/Fm % inhibition in Q.Y % inhibition in Fv’/Fm’ Top ranking germplasm accessions MT ... Significant at 1% Percent leaf yellowing and senescence (ranges) of top, middle and bottom ranking accessions selected from source bush nurseries (SBN) by empirical scoring Germplasm Nursery Yellowing ... water potential (under water stress ) Ranking of germplasm accessions (top ten) based on percent inhibitions in dark Fv/Fm, quantum yield and Fv’/Fm’ Rank Fv/Fm No 10 MT 4713 RO 4580 MT 4856...
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The Health Benefits of Physical Activity for Girls and Women ppt
... (1990) The Well-being of Canadians Canadian Fitness and Lifestyle Research Institute: Ottawa 33 Dyck, L (1998) The exercise of daily life: Towards an understanding of the meaning and practice of ... cultural meaning through body image and appearance In this way, multi-disciplinary work builds on the strengths of, and creates linkages between and among, theoretical disciplines and individual ... facilitating the process of transforming research information into knowledge and policy in order to increase the participation of women and girls in physical activity i developing links between...
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Mortgage Loan Fraud: An Update of Trends based Upon an Analysis of Suspicious Activity Reports doc
... noted below in the section on “Findings Observed from Sampled Narratives,” financial institutions are increasingly detecting fraud prior to loan funding.17 The most effective financial institutions ... documents For instance, a much greater than normal increase in year-to-year income or an occupational income far higher than those of others in the same line of work can present a red flag An effective ... perpetrated in order to obtain a more favorable finance rate Real estate investors participated in occupancy fraud for profit in 20% of these reports A small percentage of the reports involving occupancy...
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Báo cáo khoa học: Simultaneous improvement of catalytic activity and thermal stability of tyrosine phenol-lyase by directed evolution ppt
... mutation in the small domain was correlated with the stability of the substrate-binding site, as T407 was in van der Waals’ contact with important substrate-binding residues, T50 and R405, in the ... shown in Table The position corresponding to Ala13 was found to vary in sequence and identified as a serine in many known microbial species, including C freundii and E herbicola, yet was a branched ... Fig Structural symmetry and putative electrostatic interactions within intertwined N-terminal arm Broken lines represent electrostatic interactions in the vicinity of A13 in the homology model...
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Báo cáo khoa học: Kinetic properties of catecholoxidase activity of tarantula hemocyanin pot
... tarantula hemocyanin Fig Activation kinetics of hemocyanin by SDS Eurypelma hemocyanin (0.7 mgặmL)1) was activated with SDS in 0.1 M phosphate buffer (pH 7.0) at 30 C by incubating hemocyanin ... activity of hemocyanin to a much lesser degree than did phenylthiourea The binding afnity of the monophenol tyramine as an inhibitor was much weaker than that of l-mimosine and kojic acid, and azide ... Catecholoxidase activity of tarantula hemocyanin E Jaenicke and H Decker 300 Dopamine L-dopa 250 Epinephrine 200 Norepinephrine Catechol 150 1000 800 600 400 200 100 v (àMãmin1) v (àMãmin1) NADA 50 0 Substrate...
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Báo cáo khóa học: SUT2 is a novel multicopy suppressor of low activity of the cAMP/protein kinase A pathway in yeast docx
... protein Cells were fixed in 70% ethanol for DAPI staining and imaged as described in Experimental procedures Fig In uence of Sut2p on invasive growth, FLO11 expression and Ras protein level in R1278b ... rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal Biochem 72, 248–254 19 Guarente, L (1983) Yeast promoters and ... 271) 1291 Colavizza, D & Thevelein, J.M (1998) Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae...
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The Carbon and Global Warming Potential Impacts of Organic Farming: Does It Have a Significant Role in an Energy Constrained World? pptx
... a viable option, since they can play very important ecological roles on farms But it is important to optimize both human and animal feeding systems by maximizing ruminant feeding on forages/grass, ... Crops Snyder and Spaner [25] recently conducted a review of the sustainability of organic grain production on the Canadian Prairies, including many of the Canadian studies discussed in detail below ... organic and conventional farms located in alpine, upland and lowland regions Notably, and rather innovatively, the authors included an estimate for GHG impacts of the estimated land use change...
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Báo cáo Y học: Role of critical charged residues in reduction potential modulation of ferredoxin-NADP+ reductase Differential stabilization of FAD redox forms doc
... S96 (S80), bringing both side-chains into H-bonding distance [9] In the Anabaena complex, changes are observed in the relative distances and organization between the atoms of the S80 and the E301 ... stabilizing the transient semiquinone, destabilizing the flavin hydroquinone complex and therefore in uencing the FAD reduction potential, support the original hypothesis of its role in proton transfer ... side-chain is not making any contact with the FAD˚ isoalloxazine [12.40 A from K75-NH2 to CH3(8)] (Fig 1) Moreover, K75 is not involved in any intraprotein interaction, but is situated at the entrance...
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POTENTIAL CONFLICT OF INTEREST IN THE PRODUCTION OF DRUG COMPENDIA doc
... delineating points at which conflict of interest may arise; (2) an ethical framework for evaluating the potential presence and influence of conflict of interest in compendia; (3) results of an investigation ... determining a “medically-accepted indication” of drugs and biological agents used off-label in an anticancer chemotherapeutic regimen, unless the Secretary of Health and Human Services determines ... implications for drug manufacturers Listing of a product in an approved compendium confers a financial advantage to industry The basic motivation to attain listing in the compendia introduces potential...
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the impact of abc (activity based costing) on manufacturing firm performance in vietnam
... implementation In support ABC, Cagowin and Bouwman said that the transparency increasing and information accuracy is obtained form ABC adoption (Cagowin and Bouwman, 2002) However, Kaplan (1993) and others ... Manufacturing (WCM) practices WCM practices implementation requires a large range of manufacturing capabilities Since in the rapid manufacturing environment, the changes in customer demand and ... yield changes of plant in the last three years And the third variance is ΔTIME that denotes the changes on cycle time and lead time in manufacturing plant during last three years; this is also indicated...
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