Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc
Báo cáo khoa học: Residues near the N-terminus of protein B control autocatalytic proteolysis and the activity of soluble methane mono-oxygenase doc
... Residues < /b> near < /b> the < /b> N-terminus < /b> of < /b> protein < /b> B control autocatalytic proteolysis and the < /b> activity of < /b> soluble methane mono-oxygenase Anastasia J. Callaghan*, Thomas J. Smith†, Susan E. Slade and ... a mixture of < /b> proteins B and B .The < /b> relative abundance of < /b> p roteins B and B was assessed b y u...
Ngày tải lên: 31/03/2014, 09:20
Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
... dem- onstrate that the < /b> alternative insertion of < /b> two alanine residues < /b> at the < /b> N-ter- minus of < /b> the < /b> H -protein < /b> elevates the < /b> activity of < /b> P -protein < /b> by 20% in vitro, and could promote glycine decarboxylase activity ... FtGLDH AA and the < /b> artificial AtGLDH1 AA , are indeed exclusively due to the < /b> insertion of <...
Ngày tải lên: 23/03/2014, 04:20
Báo cáo khoa học: Mitochondria regulate platelet metamorphosis induced by opsonized zymosan A – activation and long-term commitment to cell death docx
... increased expression of < /b> the < /b> Bcl-2 proteins Bax and Bak, caspase activation and cell death [2,3]. In addition, the < /b> physi- ological platelet agonist thrombin also induces Bid, Bax and Bak translocation to the < /b> mitochondria ... enhanced by platelet agonists [24]. Give the < /b> importance of < /b> the < /b> loss of < /b> functional integ- rity of < /b> plate...
Ngày tải lên: 16/03/2014, 04:20
Báo cáo khoa học: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis pot
... mutagenesis of < /b> CL1 and CL2 site residues < /b> of < /b> tACE and ACE2 The < /b> residues < /b> surrounding the < /b> chloride ion at the < /b> CL1 and CL2 sites of < /b> tACE and ACE2 are shown in Fig. 1. In tACE, the < /b> residues < /b> that coordinate the < /b> ... II hydrolysis by enhancing the < /b> maximal level of < /b> activity, but not by altering the <...
Ngày tải lên: 16/03/2014, 04:20
Tài liệu Báo cáo khoa học: It is all about resolution Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia) docx
... In the < /b> absence of < /b> interferon, STAT2 perma- nently and rapidly shuttles between the < /b> cytoplasm and the < /b> nucleus. A region in the < /b> C-terminus of < /b> STAT2 controls its specific export in the < /b> absence of < /b> ... death, in both health and disease. The < /b> ubiquitin–proteasome pathway involves conjugation of < /b> multiple ubiquitin moieties to...
Ngày tải lên: 19/02/2014, 02:20
Tài liệu Báo cáo khoa học: Cell surface nucleolin on developing muscle is a potential ligand for the axonal receptor protein tyrosine phosphatase-r ppt
... electrophoresis, and this revealed a complex pattern of < /b> protein < /b> bands. The < /b> only reproducible difference observed was a 95 kDa band identified as being present in the < /b> eluate from the < /b> PTPr column, but absent ... of < /b> HB-19 were observed on the < /b> binding of < /b> antibodies to the < /b> antigens laminin and myosin (data not shown). Further pertu...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học:Symmetric fluoro-substituted diol-based HIV protease inhibitors Ortho-fluorinated and meta-fluorinated P1/P1¢-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacyy docx
... accommodated in the < /b> protease S1/S1¢ subsites, a s observed by an increase in favorable Van der Waals c ontacts and surface area buried by the < /b> inhibitors. These data will be used in the < /b> development of < /b> potent inhibitors ... P1/P1¢-benzyloxy side groups Overall. The < /b> mono- and di-substituted inhibitors 2–6 bind to the < /b> active site of < /b> the < /b>...
Ngày tải lên: 19/02/2014, 16:20
Báo cáo khoa học: Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model doc
... oxygen, both before and after treatment with a mutagen. These mutations could be within TP53 itself, or in one of < /b> the < /b> other genes capable of < /b> regulating senescence, and may contribute to the < /b> background ... contains 11 exons but most mutations are of < /b> the < /b> missense type in exons 5–8, which code for the < /b> DNA binding domain (DBD) of < /b> p53. O...
Ngày tải lên: 06/03/2014, 11:20
Báo cáo khoa học: Phytoene synthase genes in tomato (Solanum lycopersicum L.) – new data on the structures, the deduced amino acid sequences and the expression patterns doc
... of < /b> the < /b> two genes. The < /b> need for a reconstruction was based on the < /b> lack of < /b> information regarding the < /b> 5¢-region in the < /b> Psy2 DNA sequence and from the < /b> conflicting evidence avail- able in the < /b> database ... [9], the < /b> last annotation of < /b> the < /b> derived protein < /b> (P08196) still reports the < /b> presence of < /b>...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: An engineered right-handed coiled coil domain imparts extreme thermostability to the KcsA channel docx
... that of < /b> wtKcsA (Fig. 4B) . Taken together, these two results indicate that the < /b> gross biophysical nature of < /b> KcsA is not altered by the < /b> addition of < /b> RHCC. Thermostability test The < /b> thermostability of < /b> ... removal of < /b> the < /b> linker between the < /b> KcsA pore domain and the < /b> tetramer- ization domain did not improve the < /b> exp...
Ngày tải lên: 16/03/2014, 00:20