GENES AND AUTOIMMUNITY - INTRACELLULAR SIGNALING AND MICROBIOME CONTRIBUTION docx

... class I HLA-C*07 synapse genes HLA-B*08 HLA-A2 HLA class II HLA-DR3 HLA-DPB 2.1/8 HLA-DR3 HLA-DR4 HLA-DR5 HLA-DR7 HLA-DR7 HLA-DRB1 HLA-DQB1*03 HLA-DRB3 HLA-DQw7 HLA-DRB1*04 HLA-DQB1*0301 HLA-DRB4*0101 HLA-DRw53 HLA-DRw9 CTLA-4 ... GO GO HT Cytokines or TNF-α TNF-α Cytokine receptors IL-1α IL-4 IL-1β TGF-β IL-1RA IFN-© IFN-γ IL-23R Other immunological NF-κB NF-κB molecules CD226 ICAM-1 FCRL3...

Ngày tải lên: 17/03/2014, 21:20

... class I HLA-C*07 synapse genes HLA-B*08 HLA-A2 HLA class II HLA-DR3 HLA-DPB 2.1/8 HLA-DR3 HLA-DR4 HLA-DR5 HLA-DR7 HLA-DR7 HLA-DRB1 HLA-DQB1*03 HLA-DRB3 HLA-DQw7 HLA-DRB1*04 HLA-DQB1*0301 HLA-DRB4*0101 HLA-DRw53 HLA-DRw9 CTLA-4 ... GO GO HT Cytokines or TNF-α TNF-α Cytokine receptors IL-1α IL-4 IL-1β TGF-β IL-1RA IFN-© IFN-γ IL-23R Other immunological NF-κB NF-κB molecules CD226 ICAM-1 FCRL3...

Ngày tải lên: 30/03/2014, 09:20

... 41 Susan Lindquist and Karen L. Allendoerfer Tau and Intracellular Transport in Neurons 59 E M. Mandelkow, E. Thies, S. Konzack, and E. Mandelkow Signaling Between Synapse and Nucleus During ... Annaert and De Strooper 2002; Selkoe et al. 1996; Small and Gandy 2006). γ-Secretase is a multiprotein complex consisting of the catalytic presenilins-1 and -2 for activity (Annae...

Ngày tải lên: 14/02/2014, 17:20

... have an affinity for AT- and GC-rich sequences and play critical roles in the recruitment of MLL to target genes. In addition to AT-hooks and the CpG- binding activity of MLL and its interacting ... DNA-bind- ing domain is responsible for DNA binding specificity and dimerization, and the ligand-binding domain is responsible for binding of the ligand and associated induced functio...

Ngày tải lên: 16/02/2014, 14:20

... µg) Vector Vector/Sorbitol Phospho-JN K JNK JSP1 β -actin 55 55 21 123456 JSP1-wt (1.5 µg) JSP1-wt (3.0 µg) JSP1-G2A (1.5 µg) JSP1-G2A (0.6 µg) Vector Vector/Sorbitol GST-c-Jun P * -GST-c-Jun kDa A B Fig. 4. ... is Met-Gly-X 3 -Ser ⁄ Thr-Lys ⁄ Arg-, but only the require- ment for Gly at the N-terminus is absolute. For exam- ple, the tyrosine kinase c-Abl, a myristoylated protein, contains Gly...

Ngày tải lên: 16/02/2014, 14:20

Ngày tải lên: 18/02/2014, 11:20

... [190,191], Fig. 3. Epigenetic signaling for proliferation or death emanating from the plasma membrane microdomains. (A) Lipid raft-dependent (H-Ras and K-Ras-4A) and -independent (K-Ras-4B) signaling. A model ... [1,83]. Lipid rafts and Ras signaling Palmitoylation of N-Ras, K-Ras-4A and H-Ras, but not K-Ras-4B, in their C-terminal hypervariable regions is commonly required for t...

Ngày tải lên: 18/02/2014, 14:20

... R-Smads 2 and 3), the co- Smad Smad4 and the inhibitory Smads 6 and 7. All R-Smads and the co-Smad consist of three domains: the N-terminal MH1 domain, the variable proline-rich linker, and the C-terminal ... interact- ing with cell type and signal-specific transcription acti- vators or repressors. There are three classes of Smads: regulatory Smads (BMP-responsive R-Smads 1, 5 and...

Ngày tải lên: 19/02/2014, 02:20

... carboxy-terminal TRAF-C subdomain, consisting of an eight-stranded anti- parallel b-sandwich structure and a less conserved amino- terminal part, the TRAF-N domain, which is organized as a coiled-coil ... primary T-cells and Jurkat cells stimulated with the NF-jB inducers TNF or phorbol 12-myristate 13-acetate (PMA), TRAF4-mRNA was rapidly up-regulated. In Jurkat T-cells deficient for I-jB...

Ngày tải lên: 21/02/2014, 15:20

... was obtained in 3¢-RACE and a single major product of 91 bp (excluding the 38 bp 5¢-RLM-RACE adapter sequence) was obtained in 5¢-RLM-RACE (data not shown). Three clones for each 3¢-RACE and 5¢-RLM- RACE ... fabp1b gene (see Fig. 4B and dis- cussion below). Three clones were sequenced for each 3¢-RACE and 5¢-RLM-RACE product. Sequence analysis of the fabp1b 3¢-RACE and 5¢-RLM-RACE p...

Ngày tải lên: 07/03/2014, 12:20