Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... Authors Journal compilation ª 2007 FEBS The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p Ruth Nebauer1, Irmgard Schuiki1, ... cellular and mitochondrial amounts of PtdEtn (Table 1) thatexceeded wild-type levels.Deletion of OXA1 affects the rate of PtdEtnsynthesis by Psd1p in vivoBecause mitochondrial Psd1p is the major ... The rate of PtdSer synthesis decreased to 80%, the rate of PtdEtn formation to 70% and that of PtdCho synthesisto 60% of wild-type. Because Oxa1p was assumed tocompromise only the mitochondrial...
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Báo cáo khoa học: Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin pptx
... 12-O-tetradecanoylphorbol-13-acetate, and high calcium levels [38]. Furthermore,c-fos was activated during apoptosis of epithelial cells[39], and c-fos was shown to increase the sensitivity of keratinocytes [40] and other epithelial ... binding was detected by using the ECL detection kit (GE HealthCare, Athens, Greece).Isolation of total RNA and RT-PCR and northernblot hybridization analysisIsolation of total RNA and RT-PCR were ... correlated with the loss of nCLU expression and the re-expression of psCLU and sCLU (Doc. S1 and Fig. S1). Thus, ectopicoverexpression of the c-fos oncoprotein suppressed the expression of the prosurvival...
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Báo cáo khoa học: "Project for production of closed-caption TV programs for the hearing impaired" docx
... Japan. The project is supported by the Telecommunications Advancement Organisation of Japan with the help of the ministry of Posts and Telecommunications. We propose natural language and speech ... screen, there are too many of them to be understood well (Komine et al. 1996). Therefore we need to summarise the news texts to some extent, and then show them on the screen. The aim of the ... of characters. 1.2 Synchronisation of Text and Speech We need to synchronise the text with the sound, or speech of the program. This is done by hand at present and we would like to employ...
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Báo cáo khoa học: Outer sphere mutagenesis of Lactobacillus plantarum manganese catalase disrupts the cluster core pptx
... interactions with the solvent bridge (W2) and one of the metal ligands (Glu35). The latter side chain is slightlydisplaced away from the cluster (by 0.33 A˚)alongthecluster axis. The nonligand carboxylate ... A˚resolution is shown in Fig. 3. The model of Y42F LPC has 91.8% of the residues in the most favored regions of the Ramachandran plot and 8.2%in the additionally allowed regions. Some characteristics of the ... coordination chem-istry for the open and closed forms of the dimanganesecluster.Loss of one of the solvent bridges fundamentally alters the properties of the manganese ions and their electronicinteractions...
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Báo cáo khoa học: NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a-like physiological activity doc
... capable of discriminating betweenNa+-channel isoforms of the same organism (e.g. the ratbrain isoform rNaV1.1 is 10-fold more sensitive to the action of the a Na-ScTx Lqq5 than the cardiac isoform ... wereevolved in the venom of scorpions. The last of these is nottrivial, as the huge variability of these peptides, estimated tobe of the order of 100 000 in scorpion venom alone, and of which only ... subtracted the control traces from the tracesrecorded in the presence of the toxin. The amplitude of thesetoxin-induced currents was analyzed by plotting the value3 ms after the onset of the depolarizing...
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Báo cáo khoa học: A truncated form of DNA topoisomerase IIb associates with the mtDNA genome in mammalian mitochondria doc
... in the C-terminal regions of the a-andb-isoforms arelikely what makes this possible. Consequently, truncation of the C-terminal domain may be essential for the b isoform tobe targeted to the ... could be important for mitochondrial targeting as well. For many proteins impor-ted into mitochondria, the pI of the mitochondrial form of the protein is higher than that of the cytosolic protein ... (D)-loop prior to the initiation of lagging strand synthesis. Instead, synthesis of leading and lagging strands may proceed in a tightly coupled fashion[68]. The method to identify and isolate DNA...
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Tài liệu Báo cáo khoa học: Efficient killing of SW480 colon carcinoma cells by a signal transducer and activator of transcription (STAT) 3 hairpin decoy oligodeoxynucleotide – interference with interferon-c-STAT1-mediated killing pdf
... breast,head and neck, lung and colon cancers [8], is consideredto be a marker of poor prognosis. The role played by STAT3 in malignant cell growth is mediated in part by the up-regulation of the expression ... demonstrate this proposal and to identify the cellular components involved.Nevertheless, these results suggest that nuclear entry of a decoy ODN is not a prerequisite for the inhibition of transcription ... increased the pro-apoptotic effect of doxorubicin [43]. Thus, the efficiency of blocking STAT3 may depend on the absence of the inhibition of STAT1. Indeed, celldeath induced by ODN and by IFN-c...
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Báo cáo khoa học: Site specificity of yeast histone acetyltransferase B complex in vivo pot
... in histone H4 associated with the HAT-B enzymefrom the yeast soluble fraction. The requirements for the distinct components of the complex for the acetyla-tion and the association of histone ... the his-tone H4 isoform with acetylated Lys91 were detected in the soluble fraction, and the levels of both were signifi-cantly increased by HU treatment, but the amount of neither of them was ... that Hat1 is apparently notinvolved in the acetylation of any site on solublehistone H4 and histone H3 except for Lys12 and Lys5 of histone H4.Involvement of different components of the yeast HAT-B...
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Báo cáo khoa học: p53-induced inhibition of protein synthesis is independent of apoptosis pdf
... question of whether common signal-ing pathways are involved in the control of translation and in the effects of p53 on the cell cycle and/ or apoptosis willrequire the use of further mutants of p53 ... synthesis. Moreover, we have shown that theseevents are not simply the consequences of p53-inducedapoptosis and indeed occur independently of this process.Further details of the mechanisms ... consequence of either the impairment of cell cycleprogression or the induction of apoptosis, both of which areassociated with inhibition of translation in other systems[58–60]. However the question of...
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Báo cáo khoa học: "Fully Unsupervised Discovery of Concept-Specific Relationships by Web Mining" pdf
... names (consistingmostly of names of other geopolitical entities). Us-ing the list of 223 single word countries as our goldstandard, this gives precision of 0.90 and recall of 0.86. (Ten other seed ... as our gold standard, this gives pre-cision of 0.68 and recall of 0.93. The second part of the algorithm generated a set of ten binary relations. Of these, one concernedtravel and entertainment ... white space. The first stage of the algorithm returned 305 of the species listedin Wordnet, another 37 species not listed in Word-net, as well as 48 other names (consisting mostly of other sea creatures)....
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