... aB-crystallin are found in cardiac and skeletal mus-cle and are also present in the brain, lung and retina.Intracellularly, it has been proposed that the A subunitstabilizes the B subunit, and ... positionin aA-crystallin, R116C, caused congenital cataract inhumans [12]. In aA-crystallin and aB-crystallin, R116 and R120, respectively, are located within the con-served a- crystallin domain. The ... cellmembrane, and to the nuclear envelope [13]. R116CaA-crystallin causes cataract in the lens (whereaA-crystallin is mainly located), but, because aB-crys-tallin also has considerable extralenticular...