... luminal portions of all superfamilymembers contain conserved zinc-binding [13,14], heparin-binding [14] and collagen-binding domains [15]. Further-more, a GTP-binding protein (G0) binding ... in only human and rodents.APP and the APLPs are type-I transmembrane proteinscontaining a signal peptide, a large amino-terminal luminal/extracellular part, a transmembrane domain and a shortcytoplasmic ... secondheparin-binding domain [3,4,13,26].Comparative analysis of theXenopus and mammalianAPLP2 proteinsComparing the amino acid sequences of the twoX-APLP2 proteins with the human, mouse and ratAPLP2...