... promoters. Of these, amino acid residues 243 and 275 are involved in DNA binding and 244 and 246are in very close proximity to DNA binding. This indi-cates that p53R2 either does not use these residues ... towardscertain mutants. Of these, only residue 283 is involved in DNA binding. However, residues 272 and 276 are closeto DNA binding. The other four residues are furtheraway, but at the same side of the ... Among the 2314 mutants, 1148 were localized in the central coredomain of the protein and were used for training and evalua-tion of our prediction algorithm. Of the eight promoters, westudied the...