Tài liệu Báo cáo khoa học: Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase pdf

... Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase Christopher J. D. Mau 1 , Sylvie Garneau 2 , ... which did inhibit rubber transferase activity in both species. That two types of protein farnesyltransferase inhibitors could also interfere with rubber transferase, a cis-prenyltransferase, indicates ....

Ngày tải lên: 21/02/2014, 00:20

... (2001) Characterization of binding of leukotriene C4 by human multidrug resistance protein 1. Evidence of differential interactions with NH2-and COOH-proximal halves of the protein. J Biol Chem 276, ... Got- tesman MM & Roninson IB (1986) Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. C...

Ngày tải lên: 18/02/2014, 13:20

... pelleted by brief centrifugation (1 000 g, 1 min) and washed three times with buffer B, bound protein complexes were separated on a 15% gel by SDS ⁄ PAGE. Protein bands were detected by CBB staining. Coimmunoprecipitation ... were recovered by low-speed centrifugation (600 g) for 1 min, and washed five times with buffer C supplemented with 0.1% Triton X-100 and once with bu...

Ngày tải lên: 18/02/2014, 04:20

... Vriend G (1992) A database of protein structure families with common folding motifs. Protein Sci 1, 1691–1698. 21 Holm L & Sander C (1993) Protein structure compari- son by alignment of distance ... dependent on the presence of myrosinase -binding proteins. Plant Physiol 129, 1592– 1599. 10 Taipalensuu J, Eriksson S & Rask L (1997) The myro- sinase -binding protein from...

Ngày tải lên: 18/02/2014, 14:20

... amounts) into the respective Rio1p mutant proteins by protein kinase CK2; * denotes degrada- tion products. M. Angermayr et al. Rio1 protein kinase is regulated by CK2 FEBS Journal 274 (2007) 4654–4667 ... the G 1 phase [11]. Keywords atypical protein kinase; casein kinase 2 substrate; cell-cycle phase-dependent degradation; protein protein interactions; Rio1 protein kinase 2 1...

Ngày tải lên: 18/02/2014, 16:20

... gene, with 25% identity, at the amino acid level. The protein encoded by bc1534 is classified as a LmbE-related protein and hereafter will be referred to as BcZBP (B. cereus zinc -binding protein) . ... sur- face proteins. B. cereus thus provides a convenient model organism for studying proteins potentially associated with the pathogenicity of the highly infectious B. anthracis. Th...

Ngày tải lên: 19/02/2014, 00:20

... inhibited by MA. To verify this hypothesis, parasite proteins were analysed by western blot with mouse anti-P. falciparum MSP1. Incubation of synchronized cultures at schizont stage with MA for ... min, proteins from parasite extracts were obtained as described above. Parasite proteins were analysed by western blot with mouse anti-P. falciparum MSP1 (AbD Serotec, Oxford, UK), foll...

Ngày tải lên: 14/02/2014, 14:20

... heterochromatin mediated by repressive Sir protein complexes [135]. Conversely, the hetero- chromatin protein Sir2 directs deacetylation of H4-K16 and promotes heterochromatin spreading by allowing Sir3 ... opening may be driven by factors carried by the polymerase itself. The recruitment of SAGA to transcribed coding regions is also supported by Pol II CTD Ser5 phosphorylation...

Ngày tải lên: 14/02/2014, 18:20

... determined by the method of Lowry et al. [40]. N-terminal sequence data were obtained by automated Edman degradation with a Procise sequencer (Applied Biosystems, Foster City, CA, USA), equipped with ... Takahashi K, Hamilton RL & Havel RJ (1989) Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver. Proc Natl Acad Sci...

Ngày tải lên: 18/02/2014, 04:20

... RNA -binding proteins has been elucidated [1–4]. Despite this, translational control through the binding of RNA -binding proteins to 3¢ UTR tran- scripts has been poorly described in plants. PUF proteins ... the binding specificity of the subset of group I APUM proteins, showing that A. thaliana has at least six PUF proteins with conserved RNA -binding and similar specificity. The grou...

Ngày tải lên: 18/02/2014, 06:20