Tài liệu Báo cáo khoa học: Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber’s hereditary optic neuropathy docx

... al. Antioxidant defences in LHON cybrids FEBS Journal 272 (2005) 1124–1135 ª 2005 FEBS 1135 Antioxidant defences in cybrids harboring mtDNA mutations associated with Leber’s hereditary optic neuropathy Maura ... all LHON cybrids. These data suggest that, in cells carrying LHON mutations, there is a decrease in antioxidant defences, which is especiall...

Ngày tải lên: 19/02/2014, 16:20

... signaling through the low-density lipopro- tein receptor-related protein [31]. In vivo, t-PA was shown to also directly open the BBB in models of focal ischemia with complex signaling actions involving the ... a secondary elevation in MMP-9 in endothelial and glial cells within networks of regrowing microvessels [60]; and inhibition of MMPs during this delayed phase actually made ou...

Ngày tải lên: 18/02/2014, 11:20

... short interfering RNA (siRNA) in human cells. Both HO-2 mRNA and protein are expressed in the eight human cancer cell lines examined, and HO-1 expression is detectable in five of the cell lines, including ... were maintained in Dul- becco’s modified Eagle’s medium (Sigma). YN-1 cells were maintained in Iscove’s modified Dulbecco’s medium (Sigma), and K562, KG1 and Jurkat cells were mai...

Ngày tải lên: 19/02/2014, 05:20

... determined that AOP2 was absent from porcine, murine, and human plasma (data not shown). To gain insight into how AOP2 interacts with itself or other proteins, RBC stroma proteins were examined using native ... hemoglobin in RBC lysate. Cysteine 47 is essential for AOP2-heme binding The binding of AOP2 and heme led us to investigate the mechanism by which AOP2 binds to heme. All peroxire-...

Ngày tải lên: 20/02/2014, 23:20

... carcinomas; IAP, inhibitor of apoptosis protein; JNK, c-Jun NH 2 -terminal kinase; KIP, kinase inhibitor proteins; MEK, MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-activated protein kinase ... Japan Introduction The epidermal growth factor receptor (EGFR) is com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The bi...

Ngày tải lên: 16/02/2014, 09:20

Ngày tải lên: 17/02/2014, 05:20

... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy. Proteins 73, ... B, Finet S & Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinc...

Ngày tải lên: 18/02/2014, 04:20

... containing all-trans-retinyl palmitate were incubated with increas- ing amounts of purified RPE65. The production of 11-cis-retinol was found to be a linear function of RPE65 concentration within ... the sucrose gradient, owing to inherent buoyancy, separat- ing liposomes from unbound protein, which remains in the bottom fractions [23]. All-trans-retinyl palmitate was incorporated into 1,2...

Ngày tải lên: 18/02/2014, 08:20

... are linked to accessory proteins (e.g. zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial cells [8]. Occlu- din is an  65 kDa phosphoprotein ... Claudins are  22 kDa phosphoproteins that are thought to help maintain high transendothelial electrical resistance. Three types of claudins (claudin1 ⁄ 3, claudin5 and claudin12) are found in ....

Ngày tải lên: 18/02/2014, 11:20

... blood vessels in various tissues and organs, including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch ... astro- cytes and in ammatory cells, including macrophages that have in ltrated the stroke area. Zhang et al. [15] have shown that the intravenous administration of VEGF-A within 2 days af...

Ngày tải lên: 18/02/2014, 11:20