Tài liệu Báo cáo khoa học: Transduced human PEP-1–heat shock protein 27 efficiently protects against brain ischemic insult pptx

... PEP-1–HSP27 against brain ischemia J. J. An et al. 1308 FEBS Journal 275 (2008) 1296–1308 ª 2008 The Authors Journal compilation ª 2008 FEBS Transduced human PEP-1–heat shock protein 27 efficiently protects ... PEP-1–HSP27 fusion protein plays a defensive role against cell death induced by oxidative stress in the cells. Transduced PEP-1–HSP27 protects against is...

Ngày tải lên: 18/02/2014, 17:20

... in human heat shock transcription factor 1. Biochemistry 48, 3795–3797. 25 Liu PC & Thiele DJ (1999) Modulation of human heat shock factor trimerization by the linker domain. J Biol Chem 274 , ... DNA-binding domain; HDAC1, ; HDAC2, ; HR, hydrophobic heptad repeat; HSE, heat shock element; HSF, heat shock factor; HSP, heat shock protein; ncRNA, noncoding RNA; PARP, poly(AD...

Ngày tải lên: 18/02/2014, 04:20

... release from mitochondria. FEBS J 276 , 271 3 272 4. 62 Chinopoulos C & Adam-Vizi V (2010) Mitochondrial Ca(2+) sequestration and precipitation revisited. FEBS J 277 , 3637–3651. 63 Dominguez-Ramirez ... F1Fo-ATPase inhibitor protein, IF1. Cell Metab 8, 13–25. 56 Rouslin W & Broge CW (1996) IF1 function in situ in uncoupler-challenged ischemic rabbit, rat, and pigeon hearts. J B...

Ngày tải lên: 14/02/2014, 19:20

... Y (2005) Protein kinase C activates human lipocalin-type prostaglandin D synthase gene expression through de-repression of Notch-Hes signaling and enhancement of AP-2 beta function in brain- derived ... 1B). The expression of human H-PGDS in hepatocytes and adipocytes of the H-PGDS TG mice (S55) was confirmed by immunohis- tochemistry, using a specific antibody against human H-PGDS (...

Ngày tải lên: 16/02/2014, 09:20

... punctuated metalloproteinase (PUMP). Biochem J 277 , 277 279 . 10 Mecham RP, Broekelmann TJ, Fliszar CJ, Shapiro SD, Welgus HG & Senior RM (1997) Elastin degradation by matrix metalloproteinases. ... Visse R & Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 92, 827 839. 3 Sternlicht MD & Werb...

Ngày tải lên: 16/02/2014, 14:20

... and [ 125 I ]protein A were obtained from PerkinElmer Life Sci- ences (Boston, MA, USA). Recombinant human IGF-II was a gift of Lilly Research Laboratories (Indianapolis, IN, USA). The pseudoglycoprotein ... developed with [ 125 I ]protein A, followed by autoradiography and PhosphorImager analysis. Co-immunoprecipitation of soluble receptors with anti-Myc 9E10 Ig coupled to protein G-Se...

Ngày tải lên: 18/02/2014, 08:20

... changes associated with amino acid substitution in proteins. Protein Eng 3, 419–423. 30 Wang Z & Moult J (2001) SNPs, protein structure, and disease. Hum Mutat 17, 263 270 . 31 Guerois R, Nielsen JE & ... WAF1 ⁄ MDM2 1–18 54–108 V272A WAF1 ⁄ MDM2 1–3 32–49 A276T WAF1 ⁄ MDM2 2–20 53–221 R283C MDM2 0 25–153 J. Carlsson et al. Prediction of p53 mutant severity FEBS Journal 276 (2009...

Ngày tải lên: 18/02/2014, 11:20

... conditions, such as heat shock, mRNA translation undergoes rapid changes. In response to heat shock stress, cells induce the expression of a unique set of proteins called heat shock proteins (HSPs) [17,18]. ... from heat shock, within 12 h, eIF4G, PABP1 and most of the HSP27 were found in the cytoplasm. In addition, both eIF4G and PABP1 remained colocalized with HSP27. -HS HS Re12h Re24...

Ngày tải lên: 18/02/2014, 12:20

... at 4 °C. Protein concentrations were determined by the Bio-Rad protein assay (Bio-Rad, Hemel Hempstead, UK). FLAG-tagged proteins were immunoprecipitated from equal amounts of total protein by ... valosin-containing protein; Wld S , slow Wallerian degeneration protein. 1208 FEBS Journal 276 (2009) 1208–1220 ª 2009 The Authors Journal compilation ª 2009 FEBS fusion degradation prot...

Ngày tải lên: 18/02/2014, 13:20

... will probably be able to inhibit protein protein interactions in which Keywords activator protein- 1; coiled coils; electrostatic interactions; protein design; protein folding Correspondence J. ... speci- ficity and affinity for a protein target. Previously selected pairs Protein protein interactions capable of sequestering oncogenic Jun–Fos AP-1 leucine zipper proteins were previous...

Ngày tải lên: 18/02/2014, 13:20