Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx

... MINIREVIEW Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? Julia C. Fitzgerald and Helene Plun-FavreauDepartment ... Parkinson’s disease. Lancet Neurol 7,9 7–1 09.4 Hayashi S, Wakabayashi K, Ishikawa A, Nagai H, Sai-to M, Maruyama M, Takahashi T, Ozawa T, Tsuji S &Takahashi H (2000) An autopsy case of autosomal-recessive ... ofParkin, PINK1, DJ-1 and HtrA2 activity remains tobe determined.Parkin can be phosphorylated by a number of kinasesincluding casein kinase 1, protein kinase A, proteinkinase C [86] and...

Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx

... substantia nigra. In addition,typical PD cases have intracellular proteinaceous inclu-sions called Lewy bodies and Lewy neurites in thebrainstem and cortical areas. Genetic research in the past ... & Millat G (2003) Niemann–Pick disease type C. Clin Genet 64, 26 9–2 81.27 Tamura H, Takahashi T, Ban N, Torisu H, NinomiyaH, Takada G & Inagaki N (2006) Niemann–Pick typeC disease: novel ... mutations in ATP1 3A2 ,encoding a lysosomal type 5 P-type ATPase. Nat Genet38, 118 4–1 191.34 Najim al-Din AS, Wriekat A, Mubaidin A, Dasouki M& Hiari M (1994) Pallido-pyramidal degeneration,supranuclear...

Tài liệu Báo cáo khoa học: Homologous expression of the nrdF gene of Corynebacterium ammoniagenes strain ATCC 6872 generates a manganese-metallocofactor (R2F) and a stable tyrosyl radical (Y•) involved in ribonucleotide reduction ppt

... GTA GGTTGA TTT CAT GTC GAA TG-3¢; additional XbaI siteunderlined) and OB 3 (5¢-AAA AGA ATT CTT AGAAGT CCC AGT CAT CGT C-3¢; additional EcoRI siteunderlined).The ampliﬁed PCR fragment (Taq ... nrdF+gene was sequenced by a primer walkingapproach. For DNA analysis, dnastar software (DNAS-TAR Inc., Madison, WI, USA) and clone manager 5.0(Scientiﬁc & Educational Software, Cary, NC, USA) ... ⁄ PAGE [48] in a mini-gel system (BiometraGmbH, Go¨ttingen, Germany). Coomassie stained proteinbands were compared with protein molecular weight stan-dards (Amersham Pharmacia, Piscataway,...

Tài liệu Báo cáo khoa học: Identiﬁcation and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within the zebraﬁsh, Danio rerio docx

... CTGGATTGAAGCGCCCTCGGTTAATC 3¢-RACEZf5¢tbet-R1 GCTGCCTTTGTTATTTGTAAGCTTCAG 5¢-RACEZf5¢tbet-R2 GGAAACTTCCTGTCTCATCCAGTG 5¢-RACEZffoxp3-F1 GGAACACACAGAGGGGATGATA Initial PCRZffoxp3-R1 CTTCAACACGCACAAAGCAC Initial ... GTCCAGAATATTCAGCCTTTCACC 3¢-RACEZftbet-F1 CTCCCTCAAACAAACCAGAGTC Initial PCRZftbet-R1 CACTGGATGAGACAGGAAGTT Initial PCRZf3¢tbet-F1 CTTCTCCAGGACAGTCCAAAGAGTC 3¢-RACEZf3¢tbet-F2 CTGGATTGAAGCGCCCTCGGTTAATC ... 3¢-RACEZf3¢stat6-F2 CGGTAGTCAGGAAATCAATGCC 3¢-RACEZf5¢stat6-R1 CCATGTCTGCAGATGGTCGAGG 5¢-RACEZf5¢stat6-R2 GGACTGACATTGCTCCAGAGC 5¢-RACEZf3¢stat6-F3 GCTTCAGTGACTCAGAAATTGG 3¢-RACEZf3¢stat6-F4 GTCCAGAATATTCAGCCTTTCACC...

Tài liệu Báo cáo khoa học: The Saccharomyces cerevisiae vacuolar acid trehalase is targeted at the cell surface for its physiological function docx

... TTTAGAATGGCTTTTGAAAAAAATAAAAAAGACAATAAGTTTTATAACCTGAATTCGAGCTCGTTTAAACPEP4_D CAGAGAAACAAGCAAAACAAAAAGCTTTTCTTTTCACTAACGTATATGATGTTCAGCTTGAAAGCPEP4_R TAGAATGGCTTTTGAAAAAAATAAAAAAGACAATAAGTTTTATAACCTTCAAATTGCTTTGGCSGA1_D CAGAGAAACAAGCAAAACAAAAAGCTTTTCTTTTCACTAACGTATATGATGGCAAGACAAAAGATGTTSGA1_R ... CAGAGAAACAAGCAAAACAAAAAGCTTTTCTTTTCACTAACGTATATGATGGCAAGACAAAAGATGTTSGA1_R TAGAATGGCTTTTGAAAAAAATAAAAAAGACAATAAGTTTTATAACCTCTACAAACTCTGTAAAACTTATH1_suc2 AACGGCCCTTCGCAAGTGCAGCTGCGGGATGCAGTCTTGATGAATGGGTTGAACTACGATCCAGAAGCATH1_pep4 ... AACGGCCCTTCGCAAGTGCAGCTGCGGGATGCAGTCTTGATGAATGGGTTGAACTACGATCCAGAAGCATH1_pep4 TTCACTGAAGGTGGTCACGATGTTCCATTGACAAATTACTTGAACGCATTGAACTACGATCCAGAAGCATH1_pLC1 TAGAATGGCTTTTGAAAAAAATAAAAAAGACAATAAGTTTTATAACCTTTAATCATTGAGAACAATTTCCTTGATTGS....

Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx

... rat brain. J Neurosci Res58, 26 2–2 69.31 Kamiike W, Shimizu S, Hatanaka N, Morimoto Y,Miyata M, Yoshida Y & Matsuda H (1994) Hypoxia–reoxygenation causes DNA damage in hepatocytes.Transplant ... brain. Generally, this a- keto acid isassociated with protective effects against hypoxia andreoxygenation. This is mainly ascribed to its ability tomaintain redox status [17], intervening in ... 2ADP + Pi 2ATP2×FADH, H+ CytosolGlutamate5-Oxoprolineγ-Glutamyl-cysteineCysteine GlycineADP + Pi + ATP + ATPADP + Pi GlutamineGS-X(conjugate)Amino acids (AA)γ-Glutamyl-AACysteinyl-glycineγ-Glutamyl-AACysteinylglycineconjugateExtracellular...

Tài liệu Báo cáo khoa học: Roles of the human Rad51 L1 and L2 loops in DNA binding doc

... Egelman EH (1999) Human Dmc1 protein bindsDNA as an octameric ring. Proc Natl Acad Sci USA 96,1068 4–1 0688.39 Masson JY, Davies AA, Hajibagheri N, Van Dyck E,Benson FE, Stasiak AZ, Stasiak A & ... Proc Natl Acad Sci USA93, 623 6–6 240.11 Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O,Shinohara A, Ogawa H, Takata M, Yamaguchi-Iwai Y& Takeda S (1998) Rad51-deﬁcient vertebrate cells accu-mulate ... 28 7–2 93.22 Kinebuchi T, Kagawa W, Enomoto R, Tanaka K,Miyagawa K, Shibata T, Kurumizaka H & Yokoyama S(2004) Structural basis for octameric ring formation andDNA interaction of the human homologous-pairingprotein...

Tài liệu Báo cáo khoa học: Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane pptx

... B2-linker-ATTCATACCGAAAAGACCC ALR2-HIS-f ATTTTTATGAGAAAACGTGAAAAAACTTCGTAATGTCGTCCTTATCGTACGCTGCAGGTCGACALR2-HIS-r AAAGATCTGCCGACCTACCATAGCGGTCATGTTAATTGTAACGGCATCGATGAATTCGAGCTCGALR2-up ... ATGCGGCCGCGTCGACGATTGTAACGALR2-SacI-f TTTCTGCAGGAGCTCGAAAAATGCAGCATTTGGALR2-PstI-r AAACTGCAGGATTGTAACGGCTATATCTACE Alr1-rtp CAGGGTATGGATGAAACGGTTGCAlr1-rtm TGATCCCGAAGTGGAAGTAGAGCAlr2-rtp TTAAGTTCTAATGCGAGGCCATCCAlr2-rtm ... TTCGAAAAATGCAGCATTHIS3-r TCTACAAAAGCCCTCCTACCD ALR2mutR-EforCCAGGAGAGAATTCAAGTATTGCALR2mutR-ErevGCAATACTTGAATTCTCTCCTGGALR2-5¢SacII-f ATTGCAGTTGTCCALR2-SalI-r ATGCGGCCGCGTCGACGATTGTAACGALR2-SacI-f...

Tài liệu Báo cáo khoa học: Identiﬁcation of GAS-dependent interferon-sensitive target genes whose transcription is STAT2-dependent but ISGF3-independent doc

... PKRand 2¢5¢OAS also contain potential GAS-like elements,ISGF3-independent STAT2-containing complexesdependent on a functional STAT2 DNA bindingdomain do not appear to play an important role in mediating ... differentially regulated by inter-feron alpha, beta, or gamma using oligonucleotidearrays. Proc Natl Acad Sci USA 95, 1562 3–1 5628.21 Hannigan GE & Williams BR (1992) Interferon-alphaactivates ... interferon receptor(IFNAR), activates multiple intracellular signalingcascades that coordinate to trigger both the tran-scriptional activation and translational modiﬁcationsnecessary to invoke...

Tài liệu Báo cáo khoa học: Diversity and junction residues as hotspots of binding energy in an antibody neutralizing the dengue virus doc

... and Wilkins, Phila-delphia, PA, USA.11 Johnson G & Wu TT (2000) Kabat database and itsapplications: 30 years after the ﬁrst variability plot.Nucleic Acids Res 28, 21 4–2 18.12 Martin AC ... with a modiﬁcation in the mathematicalprocessing of the raw data, as previously described [48].The measurements were performed at 25 °C in NaCl ⁄ Picontaining 1% BSA. Fab4E11-H6 at a constant ... re -emerging, viral andtransmitted by the Aedes mosquitoes. Approximately100 million individuals are affected by the disease annually and one billion are at risk, mainly in the sub-tropical...

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