Tài liệu Báo cáo khoa học: Multi-targeted activity of maslinic acid as an antimalarial natural compound pdf

... al. Maslinic acid targets on Plasmodium falciparum FEBS Journal 278 (2011) 2951–2961 ª 2011 The Authors Journal compilation ª 2011 FEBS 2961 Multi-targeted activity of maslinic acid as an antimalarial natural ... process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments....

Ngày tải lên: 14/02/2014, 14:20

... a penta-EF-hand domain and is classified as an atypical calpain. As one of the significant structural features, mammalian calpain 7 possesses a tandem repeat of microtubule-interacting and transport ... binds between helices 1 and 3 [31]. Human increased sodium tolerance-1 (IST1), an or- tholog of yeast Ist1, possesses both MIM1 and MIM2 at its C-terminus [32,33]. IST1 and Ist1 ca...

Ngày tải lên: 18/02/2014, 04:20

... presence of Xantha-g mRNA was analysed in one semidominant and one recessive xantha-h mutant (Xantha- h clo 157 and xantha-h 57 , respectively). First strand cDNA was synthesized from total RNA of ... chelatase subunit, it was found that the XAN-G protein was missing in total cell extracts of the xantha-h 56 and xantha-h 57 mutants [33]. The two mutant plants are suggestedtolackexpressi...

Ngày tải lên: 19/02/2014, 12:20

... proteases: structure and mechanism of catalysis. Annu. Rev. Biochem. 46, 331–358. 43. Blow, D.M., Birktoft, J.J. & Hartley, B.S. (1969) Role of a buried acid group in the mechanism of action of ... of action of anticholinesterases. Phar- macol. Ther. 6, 579–628. 33. Fersht, A. (1999) Structure and Mechanism in Protein Science, pp. 172–173. W.H. Freeman, San Francisco. 34. Se...

Ngày tải lên: 20/02/2014, 23:20

... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1 2 3 1 1 2 3 { } 324 X ... 1 1 2 3 { } 324 X → γ, α, ∼ X γ α ∼ γ α w(X → γ, α, ∼) =  i f λ i i f i λ i ˜e ˜ f P trans ( ˜ f|˜e) P trans (˜e| ˜ f) P lex ( ˜ f|˜e) P lex (˜e| ˜ f) e D ∗ e D ∗ = P (D), D e. D = X i , i ∈ 1

Ngày tải lên: 20/02/2014, 07:20

... matrix (ECM) and basement membrane (BM). In the case of leishmaniasis, the causative parasite, Leishmania donovani, invades mammalian cells, primarily the resident macro- phages of liver and spleen, ... Membrane orientation of laminin binding protein An extracellular matrix bridging molecule of Leishmania donovani Keya Bandyopadhyay* , †, Sudipan Karmakar*, Aruna Biswas and Pijush K...

Ngày tải lên: 21/02/2014, 00:20

... the progress of the reactions of WT enzyme and other mutants is very fast. The results are summarized in Fig. 2. It is evident that the Y74W* mutant shows an enhancement of activity of 21.9-fold over ... 21 sources and the large database of TIM sequences from various sources facilitate an analysis of mutational effects. Most importantly, determination of the crystal struct...

Ngày tải lên: 18/02/2014, 11:20

... cata- lase by 71 ± 7% (Fig. 3B). This chaperone activity was not affected by increasing concentrations of Gly, but was completely abolished by intermediate and high concentrations of Lys-HCl, and was ... precipitation of insulin was decreased by 65 ± 8%. Low and intermediate con- centrations of Gly had no effect on the chaperone activity of aB-crystallin against this target prot...

Ngày tải lên: 18/02/2014, 16:20

... that of BS-RNase because of the removal of the four carboxylates. The ‘basic sur- face’ of the mutant HHP-RNase is very similar to that of RNase-AA-GG as the presence of Glu111 is coun- terbalanced ... membranes can discrim- inate RNases, and may play an important role in determining the cytotoxicity of an RNase by simply allowing, or not, an RNase to pass from one cell...

Ngày tải lên: 19/02/2014, 06:20

... interactions with Asp75 and Asn78. Site-directed mutagenesis of these residues of RTA favours the first of these models, as substitution of Asn78 with Ser yielded an RTA variant whose activity was essentially ... in Table 1. Assay of the N -glycosidase activity of ricin A chain variants The activity of each of the RTA variants was determined by assessing their ability...

Ngày tải lên: 19/02/2014, 12:20