Kết quả giải trình tự cấu trúc PGK-IL15-P2A-iCasp9-T2A-Blas

Một phần của tài liệu Xây dựng các cấu trúc biểu hiện thụ thể kháng nguyên khảm hướng đích cd19 để điều trị lơ xê mi cấp dòng lympho và thử nghiệm hiệu quả in vitro (Trang 88 - 100)

Mồi IL15-179-R

75 Mồi IL15-647-F

76 Mồi icasp9-R

78 5x10 6 10 7 2x10 7 3x10 7 0 20 40 60 80 100 Lượng tế bào % tế b ào C D 3 + biểu h iện C A R

Hình S1. Tỷ lệ tế bào sống CD3+ biểu hiện CAR sau 24 giờ chuyển nạp với các lượng PBMC khác nhau

Hình S2. Kết quả phân tích đếm dịng chảy tế bào CD3+ biểu hiện CAR trên các dịng tế bào CAR-T thế hệ thứ hai và thế hệ thứ tư

79

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Một phần của tài liệu Xây dựng các cấu trúc biểu hiện thụ thể kháng nguyên khảm hướng đích cd19 để điều trị lơ xê mi cấp dòng lympho và thử nghiệm hiệu quả in vitro (Trang 88 - 100)

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