xenobiotic and other orphan nuclear receptors

... their receptors with high affinity (dissociation constant Kd = 0.01 to 10nM) Orphan nuclear receptors and adopted orphan nuclear receptors on the other hand respond to dietary lipids, and the ... glucocorticoid and esterogen receptors, (2) the orphan nuclear receptors - whose naturally occurring ligands are not known, and (3) the ‘adopted’ orphan nuclear receptors which include receptors whose cognate ... and sophisticated control of gene expression (Levine and Tjian, 2003) 2.3 Orphan nuclear receptors The subclass of orphan nuclear receptors show the structurally conserved features of the nuclear- receptor...

Ngày tải lên: 14/09/2015, 14:04

... between PPARa and CAR, and further analysis of CAR-independent changes may reveal interactions between PPARa and other xenobiotic nuclear receptors In this study, we showed that PPARa is a xenobiotic ... elucidate the activation processes and the complex network among the xenobiotic nuclear receptors [26–30] At least some of the detoxifying enzymes in the intestine and liver must be induced by complex ... levels of other detoxifying enzyme mRNAs such as Cyp4a10, Cyp3a44, UGT2b5 and 2b37, and AKR1b8 and 1b7 were not so significant as observed in the array analysis Induction of Cyp4a10, PDK4, and CTE-1...

Ngày tải lên: 16/03/2014, 14:20

... (2006) Nuclear receptors of the honey bee: annotation and expression in the adult brain Insect Mol Biol 15, 583–595 Tan A & Palli SR (2008) Identification and characterization of nuclear receptors ... included a DNase I treatment, and cDNA synthesized as described above The time points analyzed were 1–2 and 4–5 days pre-vitellogenesis, and 6, 12, 24, 36, 48 and 72 h PBM To standardize qPCR inputs, ... others contained Nuclear receptors in Aedes aegypti erroneous exon predictions relative to their orthologs in other species To address this issue, we validated our predictions using 5¢-RACE and...

Ngày tải lên: 18/02/2014, 13:20

... J Wang et al ligand-dependent activation of transcription by other members of the NR superfamily [5] Therefore, Reverb receptors constitutively behave as unliganded receptors and repress transcription ... proto-oncogene by ROR alpha and Reverbb, two orphan members of the superfamily of nuclear hormone receptors Mol Cell Biol 17, 1860– 1867 Yin L & Lazar MA (2005) The orphan nuclear receptor Rev-erbalpha ... Geneticin (Gibco ⁄ BRL, Grand Island, NY, USA) Cells were grown in selective media for weeks, and G418-resistant colonies were established in six-well plates, expanded and cloned independently...

Ngày tải lên: 07/03/2014, 05:20

... Thermodynamic and transport properties of water and steam The different thermodynamic properties for water and steam (together with their derivatives with respect to P and T, but also P and h) demanded ... combined with other sets of algebraic equations and ODE-s coming from additional parts of 37 38 Nuclear Reactor Thermal Hydraulics and Other Applications such a complex model (heat transfer or nuclear ... terms at BC entrance PBEIN and outlet PBAIN These three parameters are needed for steady state considerations (and partially 21 22 Nuclear Reactor Thermal Hydraulics and Other Applications used...

Ngày tải lên: 23/03/2014, 03:20

... recognized by other receptors For example, vertebrate steroid hormone receptors (such as GRs, mineralcorticoid receptors, progesterone receptors and androgen Arthropod nuclear receptors receptors) ... ligand recognition and (c) cofactor interactions The 3D structure of the LBD was first analyzed for RAR [128] and RXR [129], followed by other nuclear receptors The crystal structure of nuclear receptors ... including the TRs, VDRs, PPARs and several orphan receptors, as well as EcRs EcR is officially designated as NR1H1, and other NR1 family members include E75 (NR1D3) and E78 (NR1E1) [35] In fact,...

Ngày tải lên: 23/03/2014, 04:20

... 2CPA promoter by redox-dependent binding and activation (Fig and Tab and 2) In addition, Rap2.4a availability impacts on the expression of various other nuclear encoded chloroplast proteins involved ... involved in designing experiments and drafting the manuscript MB designed and coordinated the project, carried out the experiments depicted in fig and tab and and drafted the manuscript Acknowledgements ... EMSA with a synthetic double-stranded oligonucleotide corresponding to 13 bp overlap of the fragments F4 and F5 (C) Similarity between AP-domain of Rap2.4a and other AP2-transcription factors...

Ngày tải lên: 12/08/2014, 05:20

... factors p53, NF-κB, AP-1, and STAT3; expression of cytokines and other genes; and variation in radiation and chemosensitivity [5,21-26,30-33,41-43] The p53 mutation and expression status of UM-SCC ... ABCC5, ATP1B3, and HBE1), and DNA repair (such as XPA) The main GO molecular function was DNA binding, including eight genes in histones H2A and H2B, and MYST3, THAP11 and ARID1A (Table and Additional ... phosphorylation, and co-factor interaction of wild-type and p53 mutants, and possibly other p53 family members such as p63 and p73 nucleosome is dependent upon both histone-histone and histone-DNA...

Ngày tải lên: 14/08/2014, 07:21

... ribonucleic acid N1SKM Nr5a1, Sox2, Klf4 and c-Myc N2SKM Nr5a2, Sox2, Klf4 and c-Myc N2SK Nr5a2, Sox2 and Klf4 OSK Oct4, Sox2 and Klf4 OSKM Oct4, Sox2, Klf4 and c-Myc xvi PBST Phosphate buffered ... the ICM, and on the other hand, the overexpression of Klf5 in mouse ESCs suppressed differentiation in the absence of LIF60 More interestingly, Smith and colleagues showed that the Oct4 and Stat3 ... retroviruses…… … 61 Figure Gene expression of nuclear receptors that were cloned into the pMX retroviral vector………………………………………………………………… … 63 Figure 10 Screen of nuclear receptors in search for enhancers...

Ngày tải lên: 09/09/2015, 18:56

... this aspect due to its low expression 13 1.3 Nuclear Receptors Nuclear hormone receptors (NHRs) constitute a superfamily of ligand-dependent and ligand-independent transcription factors that govern ... even though their ligands are now known The first orphan receptor was identified in 1988 and since then, the number of orphan receptors has increased tremendously (Wang and LeCluyse, 2003; Kliewer, ... 2002; Akiyama and Gonzalez, 2003) The activation of CYP3A4 promoter by the nuclear receptors heterodimer is dependent upon ligand binding leading to the binding of the nuclear receptors to the...

Ngày tải lên: 09/10/2015, 11:06

... in SHR and WKY rats Ann Lab Clin Sci 1986;16:419-426 32 Grant KE, Chandler RM, Castle AL, Ivy JL: Chromium and exercise training: effect on obese women Medicine and Science in Sports and Exercise ... for the 20th Century: Chronic and Disabling Conditions 12:1.6, October 2000 Wotecki CE, Welsh SO, Raper N, Marston RW: Recent trends and levels of dietary sugar and other caloric sweeteners In: ... blood pressure and catecholamine excretion in SHR and WKY Am J Physiol 1986;250:E381-385 Kopilas MA, Dang LNT, Anderson HDI: Effect of dietary chromium on resistance artery function and nitric oxide...

Ngày tải lên: 26/10/2012, 08:57

... to herself by a touch of the hand of Zeus, and bare a child called Epaphus And from Epaphus sprang Libya, and from Libya, Belus; and from Belus, Aegyptus and Danaus And the sons of Aegyptus willed ... gates of Argos: statue and shrines of Zeus and other deities stand around CHORUS ZEUS! Lord and guard of suppliant hands! Look down benign on us who crave Thine aid whom winds and waters drave From ... the shape of a bull And by the will of Zeus and the craft of Hermes was Argus slain Then Io was driven over far lands and seas by her madness, and came at length to the land of Egypt There was...

Ngày tải lên: 06/11/2012, 14:13

... lots and lots of cabmen as you know, hay is dear, and folks are paltry nowadays and always contriving to go by tram And yet, thank God, I have nothing to complain of I have plenty to eat and good ... shakes her head, rocks the cradle, and murmurs her song The green patch and the shadows from the trousers and the babyclothes move up and down, nod to her, and soon take possession of her brain ... has come to feed the baby, and is standing in the middle of the room While the stout, broad-shouldered woman nurses the child and soothes it, Varka stands looking at her and waiting till she Thank...

Ngày tải lên: 06/11/2012, 14:13

... record player Bob took Jean‟s right hand and helped her to stand He put his arms around her waist and said, “I love you, Jean.” “I love you too, Bob,” she replied And they were found dead by the building ... But they persisted, and grew stronger and longer with time There began to be days when instead of going out for wheelchair walks they stayed indoors and stared into each other s eyes Each seeing ... She turned and saw him in his Dress Blues, marching with his white gloved hands around the wheelchair‟s handles with brass buttons shining against his uniform Jean did a double take and was comforted...

Ngày tải lên: 06/11/2012, 16:13

... branch of Indo-European, and as such is closely related to Frisian, English, German and the Scandinavian languages It is the standard language in the Netherlands and in Flanders, the northern part ... to interference and other problems / [edited by] Michael Swan and Bernard Smith ± 2nd ed p cm ± (Cambridge handbooks for language teachers) Includes bibliographical references and index ISBN 0-521-77939-1 ... still very great The standard language is understood almost everywhere, but dialects tend to be mutually unintelligible, both in the Netherlands and in Flanders Dutch and English being so closely...

Ngày tải lên: 17/08/2013, 08:35

... mature pandan leaf 20672313 2-AP in old pandan leaf 31776315 Table Content of - AP (ng/kg) in the pandan leaves quantified by SDE-GCFID Pandan leaves Young pandan leaf Mature pandan leaf Old pandan ... clearly these changes, SDE and SPME coupling with GC-FID and GCMS were used to identify, quantify and presented in this paper MATERIALS AND METHODS 2.1 Materials The pandan (Pandanus amaryllifolius) ... like Pandan leaf (Phan Phuoc Hien, 2011) Based on the two methods we studied for extraction and quantitative analysis of 2-AP in the pandan leaf and used it as the standard for qualitative and...

Ngày tải lên: 28/08/2013, 16:28

... brave and happy and wise prince When half of the people in his land were dead, he chose a thousand healthy and happy friends and took them away from the city He took them over the hills and far ... And as they listened, some people's faces became white Other people's heads began to go round and round Others put hands to their heads, surprised by sudden strange, dream-like thoughts And ... nothing He took my hand I saw cuts and dried blood on it I cried out, jumped to the table and tried to open the box I tried and tried but I could not! I fell to the floor and broke Dentist's...

Ngày tải lên: 14/10/2013, 17:11

... Exception Handling An exception is an error that occurs at runtime Using C++’s exception handling subsystem, you can, in a structured and controlled manner, handle runtime errors When exception handling ... way is to allow multiple handlers access to the exception For example, perhaps one exception handler manages one aspect of an exception, and a second handler copes with another aspect An exception ... error-handling routine when an exception occurs The principal advantage of exception handling is that it automates much of the error-handling code that previously had to be entered “by hand” into...

Ngày tải lên: 18/10/2013, 03:15

... exception handling subsystem, you can, in a structured and controlled manner, handle runtime errors When exception handling is employed, your program automatically invokes an error-handling routine ... exception handling is that it automates much of the error-handling code that previously had to be entered “by hand” into any large program Exception Handling Fundamentals C++ exception handling ... way is to allow multiple handlers access to the exception For example, perhaps one exception handler manages one aspect of an exception, and a second handler copes with another aspect An exception...

Ngày tải lên: 19/10/2013, 03:15

... rule, penalty, standard procedure, etc.); dispense with wave (wayv) v to move up and down or back and forth; undulate to signal with an up and down or back and forth movement of the hand; n a ridge ... is a word that sounds the same as another but has a different meaning Night and knight, for example, are homophones, as are slay and sleigh, great and grate, and bear/bare There are dozens of homophones, ... a body of water a back -and- forth or up -and- down movement, especially of the hand a surge, rush, or sudden great rise O EXTRA HELP Need more practice with homophones and other commonly confused...

Ngày tải lên: 25/10/2013, 17:20