why focus on the elderly

... expression (see Figure 3) How can this be? The answer lies in the fact that the signature of transformation is not in the expression of the oncogene protein but in the alteration in the DNA by the oncogene ... analysis, let us consider the action of oncogenes only and disregard the action of suppressor genes Also, we will assume that there is a direct correlation between the set of 'environments' that ... other therapies applied such as radiation and/or chemotherapy Table (1) yields theoretical calculations of survival fractions as a function of changes of oncogene expression, differentiation and the...

Ngày tải lên: 13/08/2014, 23:20

... proportion of tumor cells gives them a selective advantage upon treatment, allowing the clone containing the mutation to expand At present there is no known mechanism for a resistanceenabling mutation ... that rational drug design will become the rule, rather than the exception Acknowledgements We thank the Victorian Breast Cancer Research Consortium (VBCRC) for support to attend the conference ... pathway Like nutlin (a cis-imidazole), these drugs sensitize the tumors to the effects of other therapies in combination, while reducing side effects on normal cells The screen, encompassing 34,000...

Ngày tải lên: 14/08/2014, 08:21

... socioeconomic, symptoms, menopause) Mean: Surgery, 4–11 radiation or chemotherapy Surgery or radiation Pelvic exenteration Surgery, 5–10 radiation or chemotherapy Surgery, 0.5–12 radiation or chemotherapy ... Skjeldestad FE, Rannestad T Socioeconomic conditions among long-term gynaecological cancer survivors: a population-based case–control study Psychooncology DOI: 10.1002/pon.157 (2009) (Epub ahead of ... survivors Long-term cancer survivors are not being routinely monitored for their cancer or cancer-related concerns and have no oncologist or oncology nurse to consult if special needs arise [42] They...

Ngày tải lên: 05/03/2014, 15:20

... with heads of the facilities and respondents were made by personnel from the national AIDS control program in each country Interview of key informants The heads of the National AIDS Control Programs, ... and their validity and reliability ascertained These were later excluded from the main study Permission to carry out the survey was obtained from the national HIV/AIDS control programs of the ... informants Using the data collection tool information on; the general features of the country's ARV supply system [accessibility, availability, funding, monitoring and supervision], qualification and training...

Ngày tải lên: 18/06/2014, 17:20

... denoting the total number of symbols in the candidate partition The numerator in the equation above consists of the MDL descriptive cost of the phrase if added to the model and encoded, while the ... description of a set containing the single element x However, beyond k∗ , the increase in the descriptive cost of the model, while reducing the cardinality of the set to which x belongs, does ... zeros that could contain only two strings Among all possible two-part descriptions of this string the combination that minimizes the two-part descriptive cost is the MDL description This example...

Ngày tải lên: 22/06/2014, 19:20

... even with the additional costs of HER2/new testing Low dose, prolonged infusion gemcitabine The encouraging response of phase I-II trials of low dose gemcitabine in prolonged infusion in the treatment ... "essential and conventional systemic anticancer drugs" still constitutes the basis of this treatment modality In addition, these conventional drugs are relatively inexpensive For breast cancer the list ... control plan for underserved countries An example of novel chronology and mode of drug administration that tests additional mechanisms of actions and indications is the metronomic use of prolonged,...

Ngày tải lên: 09/08/2014, 04:21

... http://www.wjso.com/content/6/1/132 Competing interests The authors declare that they have no competing interests Authors' contributions KLC and AH treated the patient and conceived the idea JW performed the ... unknown receptors For this reason chemotherapy with or without immunosupression is more commonly the treatment of choice There are no published reviews on response to endocrine treatment however ... was confirmed with an oral glucose tolerance test On routine review three months later her mobility had continued to decline and the impaired pin-prick sensation was now to the level of the upper...

Ngày tải lên: 09/08/2014, 07:22

... questions: "Why receiving radiation therapy; how radiation therapy is carried out, the radiation therapy, tailor made for you; preparation before radiation therapy; implications of the visit at the simulator ... professionals The theoretical model of Information Seeking Behaviour by Wilson [16] informed the decision to have two separate scales: one focusing on patient's concerns about radiation therapy and one ... Correlation Item-to-Total Correlations Initial information about radiation therapy Q1 Why I need to receive radiation therapy Q2 What radiation therapy will involve Q7 The radiation oncologist...

Ngày tải lên: 09/08/2014, 10:21

... Authors’ contributions SYR was responsible of the acquisition of data, drafting the manuscrips; KHJ was responsible of the clinical management of the patient, scientific revision, discussion and ... discovered and there was an accompanying second primary colon cancer He showed a complete response in both the metastatic urothelial cancer and colon cancer In addition to the ongoing clinical ... (FDG) uptake in the fibrotic cavitary lesion in the lung (Figure 3B) In addition, CR of the colon cancer seen in the transverse and descending colon was also confirmed by colonoscopy and PET-CT...

Ngày tải lên: 10/08/2014, 22:20

... on tumor regression [102,103] These observations have provided a strong rationale for the combination of MEK1/2 and PI3K inhibitors in cancers that harbor concurrent activating mutations in these ... reported [96] One patient with non-small cell lung cancer had stabilization of disease for months and continues on treatment Another phase I trial of GDC-0973 in combination with the phosphatidylinositol ... may contribute differentially to tumorigenesis [15,16] The physiopathological relevance of these observations to human cancer remains unclear Second, it helps understand why the first-generation...

Ngày tải lên: 10/08/2014, 22:20

... flocculation was not observed Figure shows the effect of the concentration of the polymer on the flocculation of kaolin clay When the polymer concentration was changed from zero to 12.5 ppm, the extent ... extent of flocculation showed positive correlations to the concentration of the polymer solution added, although a distinct effect was not observed when the polymer concentration was above 7.5 ppm ... following conclusions were drawn from the results of the study An extracellular polymer closely related to flocculation of activated sludge was obtained from the sludge suspension by sonication The...

Ngày tải lên: 05/09/2013, 09:08

... customer Then, they repeat it with the teacher aloud to raise awareness and practice pronunciation Controlled practice: Students practice the same conversation above substituting some words if they ... as lobby or front desk and write them on the blackboard The teacher then goes over each word explaining any difficult points and just trying to frame the context • • • • Presentation: Learners ... Relationship ESL teachers are often faced with choosing the kind of relationship they wish to establish with their students Some prefer a strict division between the student-teacher relationship...

Ngày tải lên: 06/09/2013, 10:10

... applying the second coat of paint to the patch of the wall where once the artwork stood, my then preschool-age daughter delivered her expert opinion:“This doesn’t look much gooder.” The ability ... undulate their entire bodies.” —Scientific American Writing on the Wall One of the few “bad” things I did and got punished for as a small child was writing on the wall—more precisely, drawing on the ... The fifteenth day of March, May, July, or October, and the thirteenth day of the other months in the ancient Roman calendar From Middle English, from Old French, from Latin idus ● “And on another...

Ngày tải lên: 25/10/2013, 16:20

... tradition”), the period in which my dictionary must have originated, the word conversation had the connotation we apply to intercourse today, as in the (legalistic) phrase “having carnal conversation” ... state monopsonies to gouge producers.” The Economist Making Sense of Polys and Ponys Here’s a little chart that explains the ponys and polys: monopsony: one buyer, many sellers duopsony: two ... market condition in which there is only one buyer for a product or service that’s being sold by many From Greek mono- (one) + opsonia (purchase of provisions) Some fellows pay a compliment like they...

Ngày tải lên: 25/10/2013, 16:20

... presenting the meaning and usage of a new item should be best to combine some ways rather than only one The teacher can give concise definition, detailed description, context and collocation Besides, the ... information noticed with the senses 5 2.2.1.3 Auditory perception Crystal [5], semantic feature is “a minimal contrastive element of a Audition or hearing is one of the senses, consisting of the ... [23], Jackson and Amvela b2, Connotative meaning or Connotation [13] also consider idioms as a special kind of collocation involving In [13,p.57] Amvela and Jackson point out that “connotations two...

Ngày tải lên: 26/11/2013, 13:31

... Translation theory 1.1 Definitions of translation: There are many definitions of translation all over the world Following is some typical definitions : The first definition is “Translation is the ... translation, therefore should be translated On the contrary, institutional translation is cultural, so, in principle, the terms are transferred unless they are connected with international organization ... to limitation of time and my knowledge, my study could not cover all the aspect of this theme I only focus the study on translation and translation strategies in general, and translation of English...

Ngày tải lên: 11/12/2013, 23:51

... reproduces the matter without the manner, or the content with out of the form of the original The advantage of this type of translation is that the text in TL sounds more natural On the contrary, the ... ―Honey‖ trucks They pump the septage out of the tank, and transport it to a treatment facility Therefore, based on the definition above and the context of Water sector, the suggested translation ... contribution are deeply welcome and highly appreciated In conclusion, this graduation paper is for contribution to the study of EnglishVietnamese translation in HPU only They not have any connection...

Ngày tải lên: 11/12/2013, 23:55

... translation which indicate translation is the transferring both the form and the meaning from one language to other in equivalence We continuously consider one definition of Catford: “Translation is the ... translation is the interpreting of the meaning and the subsequent production of two texts One other definition is made by the translator: “Translation can be generally defined as the action of interpretation ... INTRODUCTION Rationale of the study Weather is the condition of the atmosphere at a particular place and time, such as the temperature, and if there is wind, rain, and sun And weather forecasting is the...

Ngày tải lên: 11/12/2013, 23:55

... west On the side/ left, right/north etc side in the newspaper/ story on the radio, on television in the sky, the river, the water, the mountains on the farm / on the beach in a row on the left, on ... development / concentrate on the lesson … (e) Manner/means: diet on bananas, go on foot (f) Circumstances: on arrival, on my return, on the condition that … (g) Cause/ reason: congratulate some one on his ... to a line (onedimensional space) e.g ON the way” or a two-dimensional area e.g ON the farm”, also On the bus” (horizontal) and ON the TV (vertical) (Close, 1977:156) ON can have the following...

Ngày tải lên: 18/12/2013, 10:04