when are they appropriate and in whom
Báo cáo y học: "Androgens in rheumatoid arthritis: when are they effectors" ppt
... follicle-stimulating hormone and luteinizing hormone, and it is even more evident by looking at the levels of serum testosterone and the serum adrenal androgen DHEAS [2] During a chronic inflammatory ... However, adrenal and gonadal androgens, which exert anti-inflammatory activities, are significantly decreased in inflamed tissues (that is, synovial fluid) during active RA in both male and female ... supports a pro-inflammatory milieu at least in RA joints (Figure 1) Interestingly, increased aromatization of androgens has been demonstrated in cultured synovial cells from RA patients and the synthesized...
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Web Application Firewalls: When Are They Useful?
... Problems solved long time ago: Load balancing Clustering SSL termination and acceleration Caching and transparent compression URL rewriting and so on OWASP AppSec Europe 2006 WAF Identity ... software But in the meantime, sysadmins must something about it (Or, as I like to say: We need all the help we can get.) Insecure applications aside, WAFs are an important building block in every ... determined attacker Monitoring (logging and detection) is actually more important as it allows you to independently audit traffic, and go back in time OWASP AppSec Europe 2006 Monitoring Requirements...
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Báo cáo khoa học: "Why Are They Excited? Identifying and Explaining Spikes in Blog Mood Levels" potx
... results are presented in Section 5, and in Section we present our conclusions Related work As to burstiness phenomena in web data, Kleinberg (2002) targets email and research papers, trying to ... news corpus A headline is retrieved if it contains at least one of the overused words and is dated within the peaking interval or the day before the beginning of the peak The hits are ranked based ... streams In Proc 8th ACM SIGKDD Intern Conf on Knowledge Discovery and Data Mining, pages 1–25 R Kumar, J Novak, P Raghavan, and A Tomkins 2003 On the bursty evolution of blogspace In Proc 12th Intern...
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Seven bad classroom management strategy ideas someone has probably recommended to you in an in service, why they are counter productive, and what to do instead
... their intrinsic motivation and sense of internal locus of control So often just asking a question about how it is going, or finding something interesting about what they are doing shows that we are ... intrinsically value, we are killing their intrinsic motivation and training them to think that the only reason they would want to the task is because they are getting something non-educational for ... “who were we talking to?” “Have they just been compared?” And if so, “Do they care?” Avoiding using the words “I like” unless you are talking about your sincere personal preferences When we give...
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Managers and Leaders - Are They Different?
... culture that develops when leaders appear in organizations, managers and leaders are very different kinds of people They differ in motivation, personal history, and in how they think and act Attitudes ... calculating the interests in opposition, planning when controversial issues should surface, and reducing tensions In this enabling process, managers’ tactics appear flexible: on one hand, they negotiate ... a harmony between what they expect and what they are able to realize from life But suppose the pains of separation are amplified by a combination of parental demands and individual needs to the...
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Livestock and Climate Change What if the key actors in climate change are…cows, pigs, and chickens? docx
... is not happening is that reclaiming land used for grazing livestock and growing feed is not yet a priority; on the contrary, feed production and grazing have been fast expanding into forest www.worldwatch.org ... change in November/December 2009 | World Watch 15 Lyle Rosbotham industry This is true even though industry and investors normally thrive when they are responsive to customers and shareholders in ... low levels of incremental investment, larger amounts of GHGs mitigated for the same amount of investment, and faster returns on investment Investments in minimizing and mitigating GHGs most often...
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Government Bonds and Their Investors: What Are the Facts and Do They Matter? ppt
... that includes institutional investors is thought to contain yields and foster stability in bond prices and yields Institutional investors could be induced to increase their holdings by tightening ... euro area yields when the euro was introduced, cross-holdings continued to increase even after and reversed only recently In the United Kingdom, longterm yields declined following the increase in ... domestic institutional investors on yields It should be kept in mind, however, that investment-grade bonds are financial instruments where future income streams are known and carry minimal default...
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Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... sequencing on the two proteins, the purified protein bands were blotted onto a polyvinylidene difluoride membrane, and the individual proteins were subjected to N-terminal sequencing The N-terminus ... marker (SM) are indicated at the left of each panel The purified protein bands are indicated by solid arrowheads Fig Microsequencing analysis of the MREa-binding proteins (A) The N-terminal sequence ... Ku-70 and Ku-80 revealed that the MREa-binding proteins described herein and the Ku proteins are immunologically related The Ku protein complex is known to contain equimolar amounts of the 70- and...
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When Bonds Matter: Home Bias in Goods and Assets pptx
... equity portfolios are in fact stable and well defined once we introduce bonds Of course, introducing bonds in the model of the previous section yields an indeterminacy since markets are already locally ... appreciation (welfare based) is associated with an increase in relative spending and income 2.4 The Instability of Optimal Equity Portfolios Financial markets are locally complete when there exists ... are unlikely to be too relevant in practice First, we observe that nominal and real bonds returns are strongly correlated in industrial economies, limiting the extent to which nominal bonds are...
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Microfinance services by savings banks in Africa - The sleeping giants have started moving, but where are they going? potx
... new financing opportunities, including savings and equity investments http://www.themix.org/me_na.html Savings banks in the microfinance landscape in Africa Savings banks are a legacy of pre-independence ... funding Evidence suggests that microfinance institutions, which engage in full intermediation, grow faster and far better in outreach and financial terms than those specialising in lending only In ... resources is intensifying Financial costs are rising, albeit slowly, and institutions are outgrowing the pool of available funds Savings services are glaringly absent from the market in light of...
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Appropriate prescribing in elderly people: how well can it be measured and optimised? docx
... Higashi and colleagues43 reported a prevalence of inappropriateness of 3% in the drug-to-avoid domain, 36% in the medication-monitoring domain, and 50% in the underprescribing domain The ACOVE indicators ... falls) are included Second, indicators pertain to treatment, prevention, monitoring, education, and documentation, and they encompass overprescribing, misprescribing, and underprescribing Third, ... prescribing of long-acting benzodiazepines in intervention group, and increase of 1·1% in control group (p=0·036); no difference in long-term benzodiazepine therapy, and in combination treatment with...
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báo cáo hóa học: " Identification of symptom domains in ulcerative colitis that occur frequently during flares and are responsive to changes in disease activity" ppt
... symptom domains in questionnaire and criteria for determining frequent and responsive symptom domains Flow diagram of 28 symptom domains in questionnaire and criteria for determining frequent and responsive ... trials, including molecules targeting interleukin 12, interleukin 17, and endothelial integrins The efficacy of UC therapies in clinical trials is assessed with disease activity indices that typically ... assessed in commonly used indices We recorded and qualitatively analyzed all signs and symptoms discussed during these group interviews and compared our findings with existing index components [15]...
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PEOPLE DECISIONS Why They Matter So Much, Why They Are So Hard, and How You Can Master Them pot
... and make sure that they are in positions where they can grow and develop, and then help them so In his follow-up book, The One Thing You Need to Know About Great Managing, Great Leading, and ... training sessions In those sessions, he interviewed a professional actor (playing a job applicant) and his trainer (talking to him through a tiny earphone plugged in his ear) instructed him in ... sidebar, which I think winds up in the right place Following my graduation from college in my native Argentina, with an Industrial Engineering degree in hand, I started to work in our capital city...
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Báo cáo nghiên cứu khoa học: "TÍNH DÂN TỘC CỦA VĂN HOÁ, NGHỆ THUẬT LÀ GÌ? WHAT ARE THE NATIONAL CHARACTERISTICS IN CULTURE AND FINE ARTS?" pps
... ÂAu họ giữ kiểu lý luận (2) Còn Lênin cho rằng, người Anh thích thực tiễn Người Anh tự hào óc thực tế không ưa thích nguyên tắc chung (3) Chủ tịch Hồ Chí Minh nhắc tới Tuyên ngôn Nhân quyền Dân ... tộc văn hoá nghệ thuật kết tinh hệ thống giá trị, thước đo giá trị dân tộc hình thành lâu đời cộng đồng lịch sử; có chế kín để giữ gìn bền vững chế mở để phát triển sinh thành Tính dân tộc văn ... hành nội sinh nhằm thoả mãn nhu cầu lao động, giao tiếp, tồn phát triển dân tộc Với ý nghĩa văn hoá nghệ thuật có tính dân tộc, cần giữ gìn khứ bảo thủ tự sát, tiếp thu yếu tố ngoại sinh cách...
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Báo cáo sinh học: " CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo" pdf
... TUNEL staining, doublecortin staining, S-100b staining, and the merged image (a-d) Images taken at -4 µm; (e-h) -2 µm; (i-l) µm; (m-p) µm The congruence between the doublecortin+ staining and the ... O-2A/OPCs, and astrocytes [22] After MTT and DAPI staining, surviving cells were determined by microscopically counting all individual cells in control and treatment groups All counting was done blinded ... with cytarabine leads to increased and prolonged cell death, and decreased BrdU incorporation, in the adult mouse CNS Cell death and BrdU incorporation were examined as in Figures and (a) The...
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Báo cáo sinh học: "Q&A: What are pharmacological chaperones and why are they interesting" pdf
... glucose tolerance and insulin action in a mouse model of type diabetes These findings offer a potential new approach to improve insulin action and glucose tolerance in diabetic individuals http://jbiol.com/content/8/9/80 ... chaperones are in latestage clinical trials, including drugs for transthyretin-based amyloidosis [20-22], the imino sugar isofagomine for Gaucher disease [23-25], and 1-deoxygalactonojirimycin for Anderson-Fabry ... chaperoning of unstable mutant proteins, there is no reason, in principle, why the normal form of any protein cannot be stabilized in this way, thereby increasing its steady-state level Imagine using...
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Báo cáo khoa học: "Phospho-ERK and AKT status, but not KRAS mutation status, are associated with outcomes in rectal cancer treated with chemoradiotherapy" ppt
... visualized using 3-3 diaminobenzidine for minutes Slides were then rinsed in water, lightly counterstained in filtered Mayer’s hematoxylin, rinsed, dehydrated, cleared, and mounted The cells of interest ... 30 minutes at room temperature After rinsing in Dako wash buffer, slides were incubated with the Dako LSAB2 biotinylated link for 10 minutes at room temperature, rinsed in Dako wash buffer, and ... each 50 point decrease in p-ERK staining intensity, the risk of death increased by 32% (p = 0.06), reflecting a benefit to increased p-ERK levels A borderline significant improvement in OS was...
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Báo cáo y học: "Clade, Country and Region-specific HIV-1 Vaccines: Are they necessary" pptx
... determinants [25] Thus, superinfections are rare, even in subjects likely to have been serially exposed to viruses from different clades The rare double infections in humans (explaining the origin ... mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type strains circulating in China AIDS Res Hum Retroviruses 2002, 18(15):1135-1140 Thomson MM, Perez-Alvarez ... (HIV-1) clades: relevance to HIV-1 vaccine trials in Uganda J Infect Dis 2000, 182:1350-1356 Moore JP, Cao Y, Leu J, Qin L, Korber B, Ho DD: Inter- and intraclade neutralization of human immunodeficiency...
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Báo cáo y học: " Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults" ppt
... treatment, since rifampicin causes decrease in efavirenz and nevirapine concentrations [11-13] The CYP2B6 and CYP3A4 genes are highly polymorphic [14] and are subject to pronounce interindividual ... efavirenz and nevirapine pharmacokinetics [16,19,20] and associated with clinical response to nevirapine-containing regimens in children [16] Significant advances have led to a greater understanding ... efavirenz group and 16 in the nevirapine group) failed to continue the study because of hepatitis (2 cases in the nevirapine group), skin rash (3 in the efavirenz group and in the nevirapine group),...
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great PEOPLE DECISIONS Why They Matter So Much, Why They Are So Hard, and How You Can Master Them phần 1 ppt
... and make sure that they are in positions where they can grow and develop, and then help them so In his follow-up book, The One Thing You Need to Know About Great Managing, Great Leading, and ... diagnosing medical conditions, assessing legal risks, predicting candidates’ performances—these are just a few examples of the kinds of things that experts can and should weigh in on In Blink: ... for career success Your ability to learn also depends in part on your career choices: What kinds of learning opportunities are put in front of you in the workplace? Do new things keep coming at...
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