understandable structure good design convincing presentation
Tài liệu Báo cáo khoa học: Crystal structure of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase complexed with an analogue of 1,3-bisphospho-D-glyceric acid Selective inhibition by structure-based design docx
Ngày tải lên :
20/02/2014, 02:21
... cruzi gGAPDH Inhibitor design All structures of 1,3-BPGA analogues are given in Table Inhibitors were designed from the reference compound 2-oxo-1,5-diphosphonopentane (5); its structure retains the ... here the refined crystal structure of a complex between the T cruzi gGAPDH and this substrate isosteric analogue On the basis of this crystal structure, we were able to design selective inhibitors ... P.H & Hol, W.G.J (1995) Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana Implications for structure- based drug design and a new position for the...
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organizational structure and design
Ngày tải lên :
12/07/2014, 14:40
... production process production simple structure functional structure 10–40 Terms to Know • • • • • • • • • divisional structure team structure matrix structure project structure boundaryless organization ... organizational structures is better suited for dynamic and complex environments © 2007 Prentice Hall, Inc All rights reserved 10–29 Common Organizational Designs • Traditional Designs Simple structure ... Traditional Organizational Designs © 2007 Prentice Hall, Inc All rights reserved 10–31 Exhibit 10–8 Contemporary Organizational Designs Team Structure • What it is: A structure in which the entire...
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Structure Steel Design''''s Handbook 2009 part 1 docx
Ngày tải lên :
11/08/2014, 20:21
... Merritt & Ricketts • BUILDING DESIGN AND CONSTRUCTION HANDBOOK Other McGraw-Hill Books of Interest Beall • MASONRY DESIGN AND DETAILING Breyer • DESIGN OF WOOD STRUCTURES Brown • FOUNDATION BEHAVIOR ... STANDARD HANDBOOK OF STRUCTURAL DETAILS FOR BUILDING CONSTRUCTION Sharp • BEHAVIOR AND DESIGN OF ALUMINUM STRUCTURES Waddell & Dobrowolski • CONCRETE CONSTRUCTION HANDBOOK CONTRIBUTORS Boring, ... 11 DESIGN CRITERIA FOR BRIDGES) Geschwindner, Louis F., P.E Professor of Architectural Engineering, Pennsylvania State University, University Park, Pennsylvania (SECTION ANALYSIS OF SPECIAL STRUCTURES)...
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Structure Steel Design''''s Handbook 2009 part 2 pptx
Ngày tải lên :
11/08/2014, 20:21
... composite plastic design stresses in shear-connectors: design with for bridges design with for buildings strength of shoring of spans for transformed section for types of vibration design of web ... Stringers; Structures) Bearing bar Bearings: anchor bolts required for beam elastomeric: advantages of composition of design of pedestals for (See also shoes below) pot PTFE requirements for shoes: design ... deflection limits for design method for: ASD LFD LRFD design of: effects of traffic volume on highway loads in (See also Loads) load distribution for service-life considerations in seismic design traffic...
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Structure Steel Design''''s Handbook 2009 part 5 ppsx
Ngày tải lên :
11/08/2014, 20:21
... For some structures, however, such changes in dimensions may not be negligible In these cases, the equations of equilibrium should be defined according to the deformed geometry of the structure ... magnitude F and direction defined by angle ␣ The force acts through point A Changing any one of these designations changes the effect of the force FIGURE 3.1 Vector F represents force acting on a on ... the free body must satisfy the three equations of equilibrium [Eq (3.11)] For three-dimensional structures, the equations of equilibrium may be written ͚Fx ϭ ͚Fy ϭ ͚Fz ϭ (3.12a) ͚Mx ϭ ͚My ϭ ͚Mz...
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Structure Steel Design''''s Handbook 2009 part 6 pot
Ngày tải lên :
11/08/2014, 20:21
... Max Irvine, Cable Structures, MIT Press, Cambridge, Mass.; Prem Krishna, CableSuspended Roofs, McGraw-Hill, Inc., New York; J B Scalzi et al., Design Fundamentals of Cable Roof Structures, U.S ... Irvine, ‘‘Cable Structures’’, MIT Press, Cambridge, Mass.; Prem Krishna, CableSuspended Roofs, McGraw-Hill, Inc., New York; J B Scalzi et al., Design Fundamentals of Cable Roof Structures, U.S ... vertical member, plate The structure is symmetrical about joint As indicated in Fig 28a, 1-ft-wide strip is selected transversely across the structure at midspan This strip is designed to transmit...
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Structure Steel Design''''s Handbook 2009 part 7 doc
Ngày tải lên :
11/08/2014, 20:21
... particularly important in large structures where there will be an accumulative effect Properly made, a properly designed weld is stronger than the base metal Improperly made, even a good- looking weld may ... specifications can be specified by note or by symbol with assurance that a good connection will be obtained In making a welded design, designers should specify only the amount and size of weld actually ... be exposed where aesthetics is a design consideration, but for many types of structures, such as factories, warehouses, and incinerators, the appearance of a good weld is not critical A sound...
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Structure Steel Design''''s Handbook 2009 part 8 potx
Ngày tải lên :
11/08/2014, 20:21
... considered in design Wind-tunnel tests on a model of the structure and its neighborhood may be helpful in supplying design data (See also Sec 9.) (‘‘Minimum Design Loads for Buildings and Other Structures,’’ ... strength to resist imposed loads without exceeding the design strength in any element of the structure Of equal importance to design strength is the design requirement that a building be functional ... Heated structure Structure kept just above freezing Unheated structure 1.0 1.1 1.2 * These conditions should be representative of those which are likely to exist during the life of the structure...
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Structure Steel Design''''s Handbook 2009 part 9 pptx
Ngày tải lên :
11/08/2014, 20:21
... between welds), in DESIGN OF BUILDING MEMBERS 7.2 7.3 COMPARATIVE DESIGNS OF DOUBLE-ANGLE HANGER A composite floor framing system is to be designed for sky boxes of a sports arena structure The sky ... 21.17 ksi The design strength of the 6-in pipe, then, from Eqs (7.6) and (7.7), is Pn ϭ 0.85 ϫ 5.58 ϫ 21.17 ϭ 100.4 kips Ͼ 93.6 kips—OK DESIGN OF BUILDING MEMBERS 7.6 7.7 COMPARATIVE DESIGNS OF ... major factor in design of compression members The slenderness ratio L / r is preferably limited to 200 Most suitable steel shapes are pipes, tubes, or wide-flange sections, as designated for columns...
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Structure Steel Design''''s Handbook 2009 part 10 potx
Ngày tải lên :
11/08/2014, 20:21
... roof joist design are not applicable for floor joist design Also, the open webs of joists provide an effective means of routing mechanical ductwork throughout the floor Joists can be designed to ... frames are threedimensional lattice-type structures that span in more than one direction It is common practice to apply the ‘‘space frame’’ designation to structures that would more accurately be ... variety of structural steel floor-framing systems available, designers frequently investigate several systems during the preliminary design stage of a project The lightest FIGURE 8.12 Typical clips...
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Structure Steel Design''''s Handbook 2009 part 12 pot
Ngày tải lên :
11/08/2014, 20:21
... the equations for member design 10.3 NOMINAL LOADS The nominal loads for design should be according to the applicable code or specification under which the structure is designed or as dictated ... 10.4 DESIGN METHODS The AISI Specification is structured such that nominal strength equations are given for various types of structural members such as beams and columns For allowable stress design ... specification does not include LRFD load combinations and load factors, the structure and its components should be designed so that design strengths equal or exceed the effects of the factored nominal...
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Structure Steel Design''''s Handbook 2009 part 13 pdf
Ngày tải lên :
11/08/2014, 20:21
... statistically based determinations for structure design Only those applicable to steel bridge superstructure designs are listed See the LRFD Specification for a complete DESIGN CRITERIA FOR BRIDGES 11.19 ... present two design methods for steel bridges: service-load, or allowable-stress, design (ASD) and strength, or load-factor, design (LFD) Both are being replaced by load-and-resistance-factor design ... may often yield more economical results A structure designed by LRFD methods will be better proportioned, with all parts of the structure theoretically designed for the same degree of reliability...
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Structure Steel Design''''s Handbook 2009 part 14 potx
Ngày tải lên :
11/08/2014, 20:21
... loading for the rest of the structure It is considered good practice to keep the bridge design loading well above the economical loading capacity of rolling stock and track structure 11.35.3 Load ... term ‘‘underpass’’ is sometimes used, denoting a structure that carries the railroad traffic over the other entity 11.34 DESIGN CONSIDERATIONS Design considerations for steel railroad bridges ... provide their own design criteria to supersede or augment AREMA recommendations Also, a state Department of Transportation (DOT) may use its specifications for part of the design Designers need to...
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Structure Steel Design''''s Handbook 2009 part 15 docx
Ngày tải lên :
11/08/2014, 20:21
... Transportation Officials (AASHTO) allow load-factor design as an alternative method to allowable-stress design for design of simple and continuous beam and girder structures of moderate length and it is ... EXAMPLE—ALLOWABLE-STRESS DESIGN OF COMPOSITE, PLATE-GIRDER BRIDGE To illustrate the design procedure, a two-lane highway bridge with simply supported, composite, plate-girder stringers will be designed As ... Stringer Design Procedure The general design procedure outlined in Art 12.2 for rolled beams also holds for plate girders In this example, too, only a typical interior stringer will be designed...
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Structure Steel Design''''s Handbook 2009 part 17 ppsx
Ngày tải lên :
11/08/2014, 20:21
... later design of the Stromsund Bridge in Sweden (1955) ¨ evolved the modern cable-stayed bridge However, the biggest impetus for cable-stayed bridges came in Germany after World War II with the design ... alone The only contemporary bridge of this type is Steinman’s design for the Salazar Bridge across the Tagus River in Portugal The present structure, a conventional suspension bridge, is indicated ... and J B Scalzi, ‘‘Construction and Design of Cable-Stayed Bridges,’’ John Wiley & Sons, Inc., New York.) (W Podolny, Jr., and J B Scalzi, ‘‘Construction and Design of Cable-Stayed Bridges,’’ 2nd...
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Structure Steel Design''''s Handbook 2009 part 18 potx
Ngày tải lên :
11/08/2014, 20:21
... PRELIMINARY DESIGNS AND ESTIMATES The usual procedure followed by most designers in preliminary designs of bridges involves the following steps: Preliminary layout of structure Preliminary design ... type of structure For example, many structures have been built with a three-span continuous truss as the basic structure and with the central span arched and tied This section is limited to structures ... illustrates the design of selected components and some typical structural details 14.11.1 Design of Floor System The floor system is designed for HS20-44 loading See Art 11.4 Slab Design Assumed...
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